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@inbook{1675430,
author = {Bryja, Vítězslav and Bernatík, Ondřej},
address = {HOBOKEN},
booktitle = {WNT SIGNALING IN DEVELOPMENT AND DISEASE: MOLECULAR MECHANISMS AND BIOLOGICAL FUNCTIONS},
doi = {http://dx.doi.org/10.1002/9781118444122.ch15},
editor = {Hoppler, S Moon, RT},
keywords = {PLANAR CELL POLARITY; KINASE-I-EPSILON; SIGNALING PATHWAY; CONVERGENT EXTENSION; DIX DOMAIN; PDZ DOMAIN; DEP DOMAIN; WNT; CATENIN; UBIQUITIN},
howpublished = {tištěná verze "print"},
language = {eng},
location = {HOBOKEN},
isbn = {978-1-118-44409-2},
pages = {207-216},
publisher = {JOHN WILEY & SONS INC},
title = {Dishevelled at the Crossroads of Pathways},
url = {https://doi.org/10.1002/9781118444122.ch15},
year = {2014}
}
TY - CHAP
ID - 1675430
AU - Bryja, Vítězslav - Bernatík, Ondřej
PY - 2014
TI - Dishevelled at the Crossroads of Pathways
VL - Neuveden
PB - JOHN WILEY & SONS INC
CY - HOBOKEN
SN - 9781118444092
KW - PLANAR CELL POLARITY
KW - KINASE-I-EPSILON
KW - SIGNALING PATHWAY
KW - CONVERGENT EXTENSION
KW - DIX DOMAIN
KW - PDZ DOMAIN
KW - DEP DOMAIN
KW - WNT
KW - CATENIN
KW - UBIQUITIN
UR - https://doi.org/10.1002/9781118444122.ch15
L2 - https://doi.org/10.1002/9781118444122.ch15
N2 - Dishevelled (Dvl) is a cytoplasmic phosphoprotein required for signal transduction in the Wnt/Beta-catenin pathway and in Beta-catenin-independent, collectively called the noncanonical, Wnt pathways. Early genetic experiments in flies demonstrated that Dvl has distinct molecular functions and plays a dual role in both PCP and Beta-catenin-mediated signaling. Dvl is a modular protein that contains three well-defined structural domains linked by the intrinsically disordered regions, which are predicted to have no secondary structure. Rescue analysis using Dvl deletion mutants in flies suggested that DIX and PDZ domains are necessary for Wnt/beta-catenin pathway, whereas PDZ and DEP domains are required for Wnt/PCP pathway Among the several kinases that phosphorylate Dvl proteins, the best described and the first one to mention is casein kinase (CK) 1 Delta/Epsilon. Ubiquitination does not only target proteins for degradation, but it also has a potential to regulate the signaling abilities of modified proteins by differential linkages.
ER -
BRYJA, Vítězslav a Ondřej BERNATÍK. Dishevelled at the Crossroads of Pathways. In Hoppler, S Moon, RT. \textit{WNT SIGNALING IN DEVELOPMENT AND DISEASE: MOLECULAR MECHANISMS AND BIOLOGICAL FUNCTIONS}. HOBOKEN: JOHN WILEY \&{}amp; SONS INC, 2014, s.~207-216. ISBN~978-1-118-44409-2. Dostupné z: https://dx.doi.org/10.1002/9781118444122.ch15.
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