Direct fluorogenic detection of palladium and platinum
organometallic complexes with proteins and nucleic acids in
polyacrylamide gels

J 2020

Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels

PEKAŘÍK, Vladimír, Marie KUDLIČKOVÁ PEŠKOVÁ, Jakub DUBEN, Marek REMES, Zbynek HEGER et. al.

Základní údaje

Originální název

Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels

Autoři

PEKAŘÍK, Vladimír (203 Česká republika, garant, domácí), Marie KUDLIČKOVÁ PEŠKOVÁ (203 Česká republika, domácí), Jakub DUBEN (703 Slovensko, domácí), Marek REMES (203 Česká republika) a Zbynek HEGER (203 Česká republika)

Vydání

Scientific reports, LONDON, NATURE PUBLISHING GROUP, 2020, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.379

Kód RIV

RIV/00216224:14110/20:00116305

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1038/s41598-020-69336-w

UT WoS

000556690900051

Klíčová slova anglicky

Direct fluorogenic detection; palladium and platinum organometallic complexes; polyacrylamide gels

Štítky

14110515, CF NMR, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 10. 2024 17:26, Ing. Jana Kuchtová

Anotace

V originále

Allyl- and propargyl ethers of umbelliferone are sensitive probes for palladium and platinum, including anticancer compounds cisplatin, carboplatin and oxaliplatin, and effective for direct visualization of protein and DNA complexes with organometallic compounds in polyacrylamide gels allowing easy detection of interactions with analyzed protein or nucleic acid. Both probes can be used for fast evaluation of Pd/Pt binding to nanocarriers relevant in drug targeted therapy or specific clinically relevant target macromolecules.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

90043, velká výzkumná infrastruktura

Název: CIISB

Citovat

PEKAŘÍK, Vladimír, Marie KUDLIČKOVÁ PEŠKOVÁ, Jakub DUBEN, Marek REMES a Zbynek HEGER. Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels. Scientific reports. LONDON: NATURE PUBLISHING GROUP, 2020, roč. 10, č. 1, s. 1-10. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-020-69336-w.

@article{1676538,
   author = {Pekařík, Vladimír and Kudličková Pešková, Marie and Duben, Jakub and Remes, Marek and Heger, Zbynek},
   article_location = {LONDON},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-020-69336-w},
   keywords = {Direct fluorogenic detection; palladium and platinum organometallic complexes; polyacrylamide gels},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific reports},
   title = {Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels},
   url = {https://www.nature.com/articles/s41598-020-69336-w.pdf},
   volume = {10},
   year = {2020}
}

TY  - JOUR
ID  - 1676538
AU  - Pekařík, Vladimír - Kudličková Pešková, Marie - Duben, Jakub - Remes, Marek - Heger, Zbynek
PY  - 2020
TI  - Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels
JF  - Scientific reports
VL  - 10
IS  - 1
SP  - 1-10
EP  - 1-10
PB  - NATURE PUBLISHING GROUP
SN  - 20452322
KW  - Direct fluorogenic detection
KW  - palladium and platinum organometallic complexes
KW  - polyacrylamide gels
UR  - https://www.nature.com/articles/s41598-020-69336-w.pdf
L2  - https://www.nature.com/articles/s41598-020-69336-w.pdf
N2  - Allyl- and propargyl ethers of umbelliferone are sensitive probes for palladium and platinum, including anticancer compounds cisplatin, carboplatin and oxaliplatin, and effective for direct visualization of protein and DNA complexes with organometallic compounds in polyacrylamide gels allowing easy detection of interactions with analyzed protein or nucleic acid. Both probes can be used for fast evaluation of Pd/Pt binding to nanocarriers relevant in drug targeted therapy or specific clinically relevant target macromolecules.
ER  -

PEKAŘÍK, Vladimír, Marie KUDLIČKOVÁ PEŠKOVÁ, Jakub DUBEN, Marek REMES a Zbynek HEGER. Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels. \textit{Scientific reports}. LONDON: NATURE PUBLISHING GROUP, 2020, roč.~10, č.~1, s.~1-10. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-020-69336-w.

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