KATSANOS, A. H., A. V. ALEXANDROV, P. MANDAVA, M. KOHRMANN, L. SOINNE, A. D. BARRETO, V. K. SHARMA, Robert MIKULÍK, K. W. MUIR, T. ROTHLISBERGER, J. C. GROTTA, C. R. LEVI, C. A. MOLINA, M. SAQQUR, L. PALAIODIMOU, T. PSALTOPOULOU, M. R. VOSKO, T. MOREIRA, J. B. FIEBACH, M. RUBIERA, E. C. SANDSET, A. DE HAVENON, T. A. KENT, A. W. ALEXANDROV, P. D. SCHELLINGER a G. TSIVGOULIS. Pulse pressure variability is associated with unfavorable outcomes in acute ischaemic stroke patients treated with intravenous thrombolysis. European Journal of Neurology. Oxford: Rapid Science Ltd., 2020, roč. 27, č. 12, s. 2453-2462. ISSN 1351-5101. Dostupné z: https://dx.doi.org/10.1111/ene.14447.
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Základní údaje
Originální název Pulse pressure variability is associated with unfavorable outcomes in acute ischaemic stroke patients treated with intravenous thrombolysis
Autoři KATSANOS, A. H. (124 Kanada), A. V. ALEXANDROV (840 Spojené státy), P. MANDAVA (840 Spojené státy), M. KOHRMANN (276 Německo), L. SOINNE (246 Finsko), A. D. BARRETO (840 Spojené státy), V. K. SHARMA (702 Singapur), Robert MIKULÍK (203 Česká republika, domácí), K. W. MUIR (826 Velká Británie a Severní Irsko), T. ROTHLISBERGER (840 Spojené státy), J. C. GROTTA (840 Spojené státy), C. R. LEVI (36 Austrálie), C. A. MOLINA (724 Španělsko), M. SAQQUR (124 Kanada), L. PALAIODIMOU (300 Řecko), T. PSALTOPOULOU (300 Řecko), M. R. VOSKO (40 Rakousko), T. MOREIRA (752 Švédsko), J. B. FIEBACH (276 Německo), M. RUBIERA (724 Španělsko), E. C. SANDSET (578 Norsko), A. DE HAVENON (840 Spojené státy), T. A. KENT (840 Spojené státy), A. W. ALEXANDROV (840 Spojené státy), P. D. SCHELLINGER (276 Německo) a G. TSIVGOULIS (300 Řecko, garant).
Vydání European Journal of Neurology, Oxford, Rapid Science Ltd. 2020, 1351-5101.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30103 Neurosciences
Stát vydavatele Spojené státy
Utajení není předmětem státního či obchodního tajemství
WWW URL
Impakt faktor Impact factor: 6.089
Kód RIV RIV/00216224:14110/20:00116375
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.1111/ene.14447
UT WoS 000559990700001
Klíčová slova anglicky blood pressure; intracranial hemorrhage; outcome; pulse pressure; sonothrombolysis; stroke; thrombolysis; variability
Štítky 14110127, rivok
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Mgr. Tereza Miškechová, učo 341652. Změněno: 24. 11. 2020 12:24.
Anotace
Background and purpose Blood pressure (BP) variability has been associated with worse neurological outcomes in acute ischaemic stroke (AIS) patients receiving treatment with intravenous thrombolysis (IVT). However, no study to date has investigated whether pulse pressure (PP) variability may be a superior indicator of the total cardiovascular risk, as measured by clinical outcomes. Methods Pulse pressure variability was calculated from 24-h PP measurements following tissue plasminogen activator bolus in AIS patients enrolled in the Combined Lysis of Thrombus using Ultrasound and Systemic Tissue Plasminogen Activator for Emergent Revascularization (CLOTBUST-ER) trial. The outcomes of interest were the pre-specified efficacy and safety end-points of CLOTBUST-ER. All associations were adjusted for potential confounders in multivariable regression models. Results Data from 674 participants was analyzed. PP variability was identified as the BP parameter with the most parsimonious fit in multivariable models of all outcomes, and was independently associated (P < 0.001) with lower likelihood of both 24-h neurological improvement and 90-day independent functional outcome. PP variability was also independently related to increased odds of any intracranial bleeding (P = 0.011) and 90-day mortality (P < 0.001). Every 5-mmHg increase in the 24-h PP variability was independently associated with a 36% decrease in the likelihood of 90-day independent functional outcome (adjusted odds ratio 0.64, 95% confidence interval 0.52-0.80) and a 60% increase in the odds of 90-day mortality (adjusted odds ratio 1.60, 95% confidence interval 1.23-2.07). PP variability was not associated with symptomatic intracranial bleeding at either 24 or 36 h after IVT administration. Conclusions Increased PP variability appears to be independently associated with adverse short-term and long-term functional outcomes of AIS patients treated with IVT.
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