2020
Mesoporous silica nanoparticles functionalized with a dialkoxide diorganotin(IV) compound: In search of more selective systems against cancer cells.
DÍAZ-GARCÍA, Diana, Lucia SOMMEROVÁ, Andrea MARTIŠOVÁ, Hana SKOUPILOVÁ, Sanjiv PRASHAR et. al.Základní údaje
Originální název
Mesoporous silica nanoparticles functionalized with a dialkoxide diorganotin(IV) compound: In search of more selective systems against cancer cells.
Autoři
DÍAZ-GARCÍA, Diana, Lucia SOMMEROVÁ (703 Slovensko), Andrea MARTIŠOVÁ (703 Slovensko), Hana SKOUPILOVÁ (203 Česká republika), Sanjiv PRASHAR, Tomáš VACULOVIČ (203 Česká republika, domácí), Viktor KANICKÝ (203 Česká republika, domácí), Isabel DEL HIERRO, Roman HRSTKA (203 Česká republika, garant) a Santiago GÓMEZ-RUIZ
Vydání
Microporous and Mesoporous Materials, Amsterdam, Elsevier, 2020, 1387-1811
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
10406 Analytical chemistry
Stát vydavatele
Nizozemské království
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 5.455
Kód RIV
RIV/00216224:14310/20:00116410
Organizační jednotka
Přírodovědecká fakulta
UT WoS
000527329400017
Klíčová slova anglicky
Organotin(IV); Anticancer; Mesoporous silica nanoparticles; Cytotoxicity; Folic acid; Cell migration; Cell invasion
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 19. 10. 2020 16:19, Mgr. Marie Šípková, DiS.
Anotace
V originále
Mesoporous silica nanoparticles (MSN) have been functionalized with the polyamino ligand N-1-(3-trimethoxysilylpropyediethylenetriamine to give the material MSN-DETATMS (M1). The reaction of M1 with the diphenyltin(IV) compound Sn1 [obtained previously from the reaction of (3-glycidyloxypropyl)trimethoxysilane and diphenyltin(IV) dichloride in the presence of two equivalents of sodium hydroxide] in a quantity to obtain a theoretical 10% wt Sn/SiO2, gave the material MSN-DETATMS-O-2-SnPh2 (M2). Alternatively, M1 was reacted with folic acid to achieve the incorporation of the folate fragment via formation of an amido bond MSN-DETATMS-FA (M3) and subsequently with Snl to give the tin-functionalized material MSN-DETATMS-FA-O-2-SnPh2 (M4). M1-M4 have been characterized by several methods such as infrared spectroscopy (FT-IR), powder X-ray diffraction (XRD), X-ray fluorescence (XRF), solid-state NMR spectroscopy, nitrogen adsorption-desorption isotherms, electrochemical methods, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). All the synthesized nanomaterials have been tested in vitro against a wide variety of cancer and noncancer cells in order to determine different aspects of their antitumour effects such as cell uptake, cell death, cell migration and cell invasion, to observe whether the incorporation of folate fragments may increase the cell uptake and selectivity towards cancer cells, thus increasing their potential applicability in future chemotherapeutic approaches.