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@article{1678820, author = {DíazandGarcía, Diana and Sommerová, Lucia and Martišová, Andrea and Skoupilová, Hana and Prashar, Sanjiv and Vaculovič, Tomáš and Kanický, Viktor and del Hierro, Isabel and Hrstka, Roman and GómezandRuiz, Santiago}, article_location = {Amsterdam}, article_number = {JUN 15 2020}, doi = {http://dx.doi.org/10.1016/j.micromeso.2020.110154}, keywords = {Organotin(IV); Anticancer; Mesoporous silica nanoparticles; Cytotoxicity; Folic acid; Cell migration; Cell invasion}, language = {eng}, issn = {1387-1811}, journal = {Microporous and Mesoporous Materials}, title = {Mesoporous silica nanoparticles functionalized with a dialkoxide diorganotin(IV) compound: In search of more selective systems against cancer cells.}, url = {https://doi.org/10.1016/j.micromeso.2020.110154}, volume = {300}, year = {2020} }
TY - JOUR ID - 1678820 AU - Díaz-García, Diana - Sommerová, Lucia - Martišová, Andrea - Skoupilová, Hana - Prashar, Sanjiv - Vaculovič, Tomáš - Kanický, Viktor - del Hierro, Isabel - Hrstka, Roman - Gómez-Ruiz, Santiago PY - 2020 TI - Mesoporous silica nanoparticles functionalized with a dialkoxide diorganotin(IV) compound: In search of more selective systems against cancer cells. JF - Microporous and Mesoporous Materials VL - 300 IS - JUN 15 2020 SP - 1-14 EP - 1-14 PB - Elsevier SN - 13871811 KW - Organotin(IV) KW - Anticancer KW - Mesoporous silica nanoparticles KW - Cytotoxicity KW - Folic acid KW - Cell migration KW - Cell invasion UR - https://doi.org/10.1016/j.micromeso.2020.110154 L2 - https://doi.org/10.1016/j.micromeso.2020.110154 N2 - Mesoporous silica nanoparticles (MSN) have been functionalized with the polyamino ligand N-1-(3-trimethoxysilylpropyediethylenetriamine to give the material MSN-DETATMS (M1). The reaction of M1 with the diphenyltin(IV) compound Sn1 [obtained previously from the reaction of (3-glycidyloxypropyl)trimethoxysilane and diphenyltin(IV) dichloride in the presence of two equivalents of sodium hydroxide] in a quantity to obtain a theoretical 10% wt Sn/SiO2, gave the material MSN-DETATMS-O-2-SnPh2 (M2). Alternatively, M1 was reacted with folic acid to achieve the incorporation of the folate fragment via formation of an amido bond MSN-DETATMS-FA (M3) and subsequently with Snl to give the tin-functionalized material MSN-DETATMS-FA-O-2-SnPh2 (M4). M1-M4 have been characterized by several methods such as infrared spectroscopy (FT-IR), powder X-ray diffraction (XRD), X-ray fluorescence (XRF), solid-state NMR spectroscopy, nitrogen adsorption-desorption isotherms, electrochemical methods, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). All the synthesized nanomaterials have been tested in vitro against a wide variety of cancer and noncancer cells in order to determine different aspects of their antitumour effects such as cell uptake, cell death, cell migration and cell invasion, to observe whether the incorporation of folate fragments may increase the cell uptake and selectivity towards cancer cells, thus increasing their potential applicability in future chemotherapeutic approaches. ER -
DÍAZ-GARCÍA, Diana, Lucia SOMMEROVÁ, Andrea MARTIŠOVÁ, Hana SKOUPILOVÁ, Sanjiv PRASHAR, Tomáš VACULOVIČ, Viktor KANICKÝ, Isabel DEL HIERRO, Roman HRSTKA a Santiago GÓMEZ-RUIZ. Mesoporous silica nanoparticles functionalized with a dialkoxide diorganotin(IV) compound: In search of more selective systems against cancer cells. \textit{Microporous and Mesoporous Materials}. Amsterdam: Elsevier, 2020, roč.~300, JUN 15 2020, s.~1-14. ISSN~1387-1811. Dostupné z: https://dx.doi.org/10.1016/j.micromeso.2020.110154.
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