Applicability of capillary electrophoresis-frontal analysis for
displacement studies: effect of several drugs on L-tryptophan
and lidocaine binding to human serum albumin

J 2020

Applicability of capillary electrophoresis-frontal analysis for displacement studies: effect of several drugs on L-tryptophan and lidocaine binding to human serum albumin

NEVÍDALOVÁ, Hana, Lenka MICHALCOVÁ a Zdeněk GLATZ

Základní údaje

Originální název

Applicability of capillary electrophoresis-frontal analysis for displacement studies: effect of several drugs on L-tryptophan and lidocaine binding to human serum albumin

Autoři

NEVÍDALOVÁ, Hana (203 Česká republika, domácí), Lenka MICHALCOVÁ (203 Česká republika, domácí) a Zdeněk GLATZ (203 Česká republika, garant, domácí)

Vydání

Journa of Separation Science, Weinheim, Wiley-VCH, 2020, 1615-9306

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10406 Analytical chemistry

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.645

Kód RIV

RIV/00216224:14310/20:00114321

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1002/jssc.202000594

UT WoS

000582531000001

Klíčová slova česky

CE; albumin; lečivo

Klíčová slova anglicky

CE; Albumin; Drug

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 3. 2021 09:57, Mgr. Marie Šípková, DiS.

Anotace

ORIG CZ

V originále

In this study, the binding characteristics of six drugs with human serum albumin, the most abundant protein in human plasma, were determined by capillary electrophoresis-frontal analysis, and the obtained values of binding parameters were compared with the literature data. The affect of several drugs and site markers on the binding of L-tryptophan and lidocaine to human serum albumin was investigated in subsequent displacement studies which thus demonstrated the usability of capillary electrophoresis as an automated high-throughput screening method for drug-protein binding studies.

Česky

Byly provedeny vytěsňovací studie.

Návaznosti

GA19-08358S, projekt VaV

Název: Nové přístupy pro studium afinitních interakcí založené na kapilární elektroforéze

Investor: Grantová agentura ČR, Nove přístupy pro studium afinitních interakcí založené na kapilární elektroforéze

Citovat

NEVÍDALOVÁ, Hana, Lenka MICHALCOVÁ a Zdeněk GLATZ. Applicability of capillary electrophoresis-frontal analysis for displacement studies: effect of several drugs on L-tryptophan and lidocaine binding to human serum albumin. Journa of Separation Science. Weinheim: Wiley-VCH, 2020, roč. 43, č. 22, s. 4225-4233. ISSN 1615-9306. Dostupné z: https://dx.doi.org/10.1002/jssc.202000594.

@article{1679993,
   author = {Nevídalová, Hana and Michalcová, Lenka and Glatz, Zdeněk},
   article_location = {Weinheim},
   article_number = {22},
   doi = {http://dx.doi.org/10.1002/jssc.202000594},
   keywords = {CE; Albumin; Drug},
   language = {eng},
   issn = {1615-9306},
   journal = {Journa of Separation Science},
   title = {Applicability of capillary electrophoresis-frontal analysis for displacement studies: effect of several drugs on L-tryptophan and lidocaine binding to human serum albumin},
   url = {https://doi.org/10.1002/jssc.202000594},
   volume = {43},
   year = {2020}
}

TY  - JOUR
ID  - 1679993
AU  - Nevídalová, Hana - Michalcová, Lenka - Glatz, Zdeněk
PY  - 2020
TI  - Applicability of capillary electrophoresis-frontal analysis for displacement studies: effect of several drugs on L-tryptophan and lidocaine binding to human serum albumin
JF  - Journa of Separation Science
VL  - 43
IS  - 22
SP  - 4225-4233
EP  - 4225-4233
PB  - Wiley-VCH
SN  - 16159306
KW  - CE
KW  - Albumin
KW  - Drug
UR  - https://doi.org/10.1002/jssc.202000594
L2  - https://doi.org/10.1002/jssc.202000594
N2  - In this study, the binding characteristics of six drugs with human serum albumin, the most abundant protein in human plasma, were determined by capillary electrophoresis-frontal analysis, and the obtained values of binding parameters were compared with the literature data. The affect of several drugs and site markers on the binding of L-tryptophan and lidocaine to human serum albumin was investigated in subsequent displacement studies which thus demonstrated the usability of capillary electrophoresis as an automated high-throughput screening method for drug-protein binding studies.
ER  -

NEVÍDALOVÁ, Hana, Lenka MICHALCOVÁ a Zdeněk GLATZ. Applicability of capillary electrophoresis-frontal analysis for displacement studies: effect of several drugs on L-tryptophan and lidocaine binding to human serum albumin. \textit{Journa of Separation Science}. Weinheim: Wiley-VCH, 2020, roč.~43, č.~22, s.~4225-4233. ISSN~1615-9306. Dostupné z: https://dx.doi.org/10.1002/jssc.202000594.

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