Seasonal variation of endocrine disrupting potentials of
pollutant mixtures associated with various size-fractions of
inhalable air particulate matter

J 2020

Seasonal variation of endocrine disrupting potentials of pollutant mixtures associated with various size-fractions of inhalable air particulate matter

NOVÁK, Jiří; Anita VACULOVIČ; Jana KLÁNOVÁ; John Paul GIESY; Klára HILSCHEROVÁ et al.

Základní údaje

Originální název

Seasonal variation of endocrine disrupting potentials of pollutant mixtures associated with various size-fractions of inhalable air particulate matter

Autoři

NOVÁK, Jiří; Anita VACULOVIČ; Jana KLÁNOVÁ; John Paul GIESY a Klára HILSCHEROVÁ

Vydání

Environmental Pollution, Oxford, ELSEVIER SCI LTD, 2020, 0269-7491

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 8.071

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/20:00114324

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

PM size Fractions; AhR-mediated toxicity; Estrogenicity; Anti-androgenicity; Ambient air

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 6. 2025 15:41, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Ambient air pollution, namely exposure to air particulate matter (PM), has been shown to be connected with a number of adverse health effects. At least part of the effects can be caused by organic pollutant mixtures associated with PM, which can elicit a wide range of specific toxic potentials. These potentials could be affected by seasonal variation of pollutant mixtures and PM size fraction. To examine this, six size subfractions of PM10 were collected at rural and urban site in the Czech Republic in a year-long sampling campaign. The samples were assessed for aryl hydrocarbon (AhR)-mediated activity, estrogenicity and anti-androgenicity using mammalian cell models. The concentrations of detected toxic potentials differed among seasons. The greatest levels were observed in samples collected during winter when AhR-mediated effects and estrogenicity were at least 10-times greater than in summer. While the observed potentials were mostly less pronounced in samples from rural area, during winter, their AhR-mediated activity was twice as great as at the urban site. This was probably caused by the low-quality of fuel used for heating at the rural site. Assessed toxic potentials were associated mainly with PM size fractions with lesser aerodynamic diameters (<1 mu m). Toxic potentials were compared with data from chemical analyses covering 102 chemicals from different pollutant groups to model their contribution to the observed effects. For AhR-mediated activity, chemical analyses explained on average 44% of the effect and the main identified effect-drivers were polycyclic aromatic hydrocarbons. For estrogenicity and antiandrogenicity, detected chemicals were able to explain on average less than 1.6% and 11% of the potentials, with their highest explicability reaching 13% and 57%, respectively. This was affected by the lack of data on specific toxic potency of some detected air pollutants, but also indicates a possible role of further not analyzed chemicals in these effects.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

GA16-11537S, projekt VaV

Název: Transformační produkty mono- a polyaromatických uhlovodíků v atmosferických aerosolech – prioritní nebezpečné polutanty

Investor: Grantová agentura ČR, Transformační produkty mono- a polyaromatických uhlovodíků v atmosferických aerosolech – prioritní nebezpečné polutanty

90121, velká výzkumná infrastruktura

Název: RECETOX RI

Citovat

NOVÁK, Jiří; Anita VACULOVIČ; Jana KLÁNOVÁ; John Paul GIESY a Klára HILSCHEROVÁ. Seasonal variation of endocrine disrupting potentials of pollutant mixtures associated with various size-fractions of inhalable air particulate matter. Environmental Pollution. Oxford: ELSEVIER SCI LTD, 2020, roč. 264, September 2020, s. 1-9. ISSN 0269-7491. Dostupné z: https://doi.org/10.1016/j.envpol.2020.114654.

@article{1680278,
   author = {Novák, Jiří and Vaculovič, Anita and Klánová, Jana and Giesy, John Paul and Hilscherová, Klára},
   article_location = {Oxford},
   article_number = {September 2020},
   doi = {https://doi.org/10.1016/j.envpol.2020.114654},
   keywords = {PM size Fractions; AhR-mediated toxicity; Estrogenicity; Anti-androgenicity; Ambient air},
   language = {eng},
   issn = {0269-7491},
   journal = {Environmental Pollution},
   note = {CZ.02.1.01/0.0/0.0/18_046/0015975 neuplatňovat.},
   title = {Seasonal variation of endocrine disrupting potentials of pollutant mixtures associated with various size-fractions of inhalable air particulate matter},
   url = {https://www.sciencedirect.com/science/article/pii/S026974912030662X?via%3Dihub},
   volume = {264},
   year = {2020}
}

TY  - JOUR
ID  - 1680278
AU  - Novák, Jiří - Vaculovič, Anita - Klánová, Jana - Giesy, John Paul - Hilscherová, Klára
PY  - 2020
TI  - Seasonal variation of endocrine disrupting potentials of pollutant mixtures associated with various size-fractions of inhalable air particulate matter
JF  - Environmental Pollution
VL  - 264
IS  - September 2020
SP  - 1-9
EP  - 1-9
PB  - ELSEVIER SCI LTD
SN  - 02697491
N1  - CZ.02.1.01/0.0/0.0/18_046/0015975 neuplatňovat.
KW  - PM size Fractions
KW  - AhR-mediated toxicity
KW  - Estrogenicity
KW  - Anti-androgenicity
KW  - Ambient air
UR  - https://www.sciencedirect.com/science/article/pii/S026974912030662X?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S026974912030662X?via%3Dihub
N2  - Ambient air pollution, namely exposure to air particulate matter (PM), has been shown to be connected with a number of adverse health effects. At least part of the effects can be caused by organic pollutant mixtures associated with PM, which can elicit a wide range of specific toxic potentials. These potentials could be affected by seasonal variation of pollutant mixtures and PM size fraction. To examine this, six size subfractions of PM10 were collected at rural and urban site in the Czech Republic in a year-long sampling campaign. The samples were assessed for aryl hydrocarbon (AhR)-mediated activity, estrogenicity and anti-androgenicity using mammalian cell models. The concentrations of detected toxic potentials differed among seasons. The greatest levels were observed in samples collected during winter when AhR-mediated effects and estrogenicity were at least 10-times greater than in summer. While the observed potentials were mostly less pronounced in samples from rural area, during winter, their AhR-mediated activity was twice as great as at the urban site. This was probably caused by the low-quality of fuel used for heating at the rural site. Assessed toxic potentials were associated mainly with PM size fractions with lesser aerodynamic diameters (<1 mu m). Toxic potentials were compared with data from chemical analyses covering 102 chemicals from different pollutant groups to model their contribution to the observed effects. For AhR-mediated activity, chemical analyses explained on average 44% of the effect and the main identified effect-drivers were polycyclic aromatic hydrocarbons. For estrogenicity and antiandrogenicity, detected chemicals were able to explain on average less than 1.6% and 11% of the potentials, with their highest explicability reaching 13% and 57%, respectively. This was affected by the lack of data on specific toxic potency of some detected air pollutants, but also indicates a possible role of further not analyzed chemicals in these effects.
ER  -

NOVÁK, Jiří; Anita VACULOVIČ; Jana KLÁNOVÁ; John Paul GIESY a Klára HILSCHEROVÁ. Seasonal variation of endocrine disrupting potentials of pollutant mixtures associated with various size-fractions of inhalable air particulate matter. \textit{Environmental Pollution}. Oxford: ELSEVIER SCI LTD, 2020, roč.~264, September 2020, s.~1-9. ISSN~0269-7491. Dostupné z: https://doi.org/10.1016/j.envpol.2020.114654.

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