OXIDATION SIGNALS OF INSULIN ON SCREEN-PRINTED ELECTRODES

D 2020

OXIDATION SIGNALS OF INSULIN ON SCREEN-PRINTED ELECTRODES

TŘÍSKOVÁ, Iveta, Tadeja JANC a Libuše TRNKOVÁ

Základní údaje

Originální název

OXIDATION SIGNALS OF INSULIN ON SCREEN-PRINTED ELECTRODES

Autoři

TŘÍSKOVÁ, Iveta, Tadeja JANC a Libuše TRNKOVÁ

Vydání

1. vyd. Brno, XX. Workshop of Biophysical Chemists and Electrochemists, od s. 66-67, 2 s. 2020

Nakladatel

Masarykova univerzita

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

10405 Electrochemistry

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

elektronická verze "online"

Odkazy

URL

Organizační jednotka

Přírodovědecká fakulta

ISBN

978-80-210-9655-4

Klíčová slova anglicky

insulin; modified screen-printed electrodes; voltammetry

Změněno: 12. 5. 2021 17:33, Mgr. Marie Šípková, DiS.

Anotace

V originále

Direct and efficient electro-oxidation of insulin is important for the development of fast and sensitive electrochemical detectors for this hormone [1,2]. However, the study of the oxidation processes of insulin on conventional graphite electrodes is limited by the very slow electron transfer kinetics. To overcome this shortcoming, it is possible to modify the electrode surface with a suitable catalyst, which reduces the value of the polarization overvoltage and the oxidation signals are measurable in the potential window area of the treated electrode. There are a number of modifying agents, ranging from various nanoparticles and nanocomposites to metal and polymer layers [3-6]. To realize our idea to catalyze the direct oxidation process of insulin (Figure 1), we chose two types of surface modifications of the graphite electrode, namely the modified screen-printed carbon electrodes (SPCEs) with bismuth oxide [7,8] or carbon nanofibers [9]. Using both types of SPCEs, the linear sweep voltammetric (LSV) signals of recombinant human insulin were recorded. This research is the starting point for the development of a nanostructured non-enzymatic insulin sensor with the highest possible sensitivity, which will be ensured not only by the optimal experimental conditions but also by suitable electroanalytical methods. In order to understand the catalytic effect of nanoparticles modifying the surface of an electrochemical sensor, our further research will focus on the study of the morphology of electrode surfaces in relation to the kinetics of electron transfer in the oxidation process of insulin.

Návaznosti

EF16_018/0002593, projekt VaV

Název: Rozvoj doktorského studia chemie

MUNI/A/1424/2019, interní kód MU

Název: Vývoj metod a instrumentace pro analýzu biologicky významných látek 2020

Investor: Masarykova univerzita, Vývoj metod a instrumentace pro analýzu biologicky významných látek 2020, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

TŘÍSKOVÁ, Iveta, Tadeja JANC a Libuše TRNKOVÁ. OXIDATION SIGNALS OF INSULIN ON SCREEN-PRINTED ELECTRODES. Online. In Libuše Trnková. XX. Workshop of Biophysical Chemists and Electrochemists. 1. vyd. Brno: Masarykova univerzita, 2020, s. 66-67. ISBN 978-80-210-9655-4.

@inproceedings{1680522,
   author = {Třísková, Iveta and Janc, Tadeja and Trnková, Libuše},
   address = {Brno},
   booktitle = {XX. Workshop of Biophysical Chemists and Electrochemists},
   edition = {1},
   editor = {Libuše Trnková},
   keywords = {insulin; modified screen-printed electrodes; voltammetry},
   howpublished = {elektronická verze "online"},
   language = {eng},
   location = {Brno},
   isbn = {978-80-210-9655-4},
   pages = {66-67},
   publisher = {Masarykova univerzita},
   title = {OXIDATION SIGNALS OF INSULIN ON SCREEN-PRINTED ELECTRODES},
   url = {https://www.sci.muni.cz/labifel/files/soubory/sbornik_2020.pdf},
   year = {2020}
}

TY  - JOUR
ID  - 1680522
AU  - Třísková, Iveta - Janc, Tadeja - Trnková, Libuše
PY  - 2020
TI  - OXIDATION SIGNALS OF INSULIN ON SCREEN-PRINTED ELECTRODES
PB  - Masarykova univerzita
CY  - Brno
SN  - 9788021096554
KW  - insulin
KW  - modified screen-printed electrodes
KW  - voltammetry
UR  - https://www.sci.muni.cz/labifel/files/soubory/sbornik_2020.pdf
N2  - Direct and efficient electro-oxidation of insulin is important for the development of fast and sensitive electrochemical detectors for this hormone [1,2]. However, the study of the oxidation processes of insulin on conventional graphite electrodes is limited by the very slow electron transfer kinetics. To overcome this shortcoming, it is possible to modify the electrode surface with a suitable catalyst, which reduces the value of the polarization overvoltage and the oxidation signals are measurable in the potential window area of the treated electrode. There are a number of modifying agents, ranging from various nanoparticles and nanocomposites to metal and polymer layers [3-6]. To realize our idea to catalyze the direct oxidation process of insulin (Figure 1), we chose two types of surface modifications of the graphite electrode, namely the modified screen-printed carbon electrodes (SPCEs) with bismuth oxide [7,8] or carbon nanofibers [9]. Using both types of SPCEs, the linear sweep voltammetric (LSV) signals of recombinant human insulin were recorded. This research is the starting point for the development of a nanostructured non-enzymatic insulin sensor with the highest possible sensitivity, which will be ensured not only by the optimal experimental conditions but also by suitable electroanalytical methods. In order to understand the catalytic effect of nanoparticles modifying the surface of an electrochemical sensor, our further research will focus on the study of the morphology of electrode surfaces in relation to the kinetics of electron transfer in the oxidation process of insulin.
ER  -

TŘÍSKOVÁ, Iveta, Tadeja JANC a Libuše TRNKOVÁ. OXIDATION SIGNALS OF INSULIN ON SCREEN-PRINTED ELECTRODES. Online. In Libuše Trnková. \textit{XX. Workshop of Biophysical Chemists and Electrochemists}. 1. vyd. Brno: Masarykova univerzita, 2020, s.~66-67. ISBN~978-80-210-9655-4.

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