The novel tyrosine kinase inhibitor ponatinib (iclusig® ) provides new hope for CML patients following previous therapy failure

JABBOUR, E., T. LION, J. APPERLEY, L. LUCIANO a Daniela ŽÁČKOVÁ. The novel tyrosine kinase inhibitor ponatinib (iclusig® ) provides new hope for CML patients following previous therapy failure. Hematology. 2016, roč. 52, 1-2, s. 84-89. ISSN 2367-7864.

Základní údaje

Originální název

The novel tyrosine kinase inhibitor ponatinib (iclusig® ) provides new hope for CML patients following previous therapy failure

Autoři

JABBOUR, E., T. LION, J. APPERLEY, L. LUCIANO a Daniela ŽÁČKOVÁ

Vydání

Hematology, 2016, 2367-7864

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Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30205 Hematology

Stát vydavatele

Bulharsko

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Lékařská fakulta

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Anotace

V originále

Chronic myeloid leukemia is a potentially fatal disease. First-generation and second-generation TKIs provided major advances in therapy, but a proportion of these patients require other treatment options. Ponatinib was developed to fulfll this need, and it has proven to be highly effective in patients where the second-generation TKIs nilotinib and dasatinib fail. The beneft-to-risk ratio for ponatinib is high, although there is an increased risk of vascular occlusive events. Patient monitoring with active management of modifable risk factors (e.g. hypertension, lipids), and decreasing the dose once optimal response is achieved is recommended. Stem-cell transplantation still remains a curative option to be considered, but morbidity and mortality are high.