Genotyping of Treponema pallidumin Cuba (2018-2019): Increased
Circulation of Recombinant Genotype and No New Treponema
pallidum Subspeciesendemicum Infection Among Syphilis Patients

J 2020

Genotyping of Treponema pallidumin Cuba (2018-2019): Increased Circulation of Recombinant Genotype and No New Treponema pallidum Subspeciesendemicum Infection Among Syphilis Patients

NODA, Angel A., Islay RODRIGUEZ a David ŠMAJS

Základní údaje

Originální název

Genotyping of Treponema pallidumin Cuba (2018-2019): Increased Circulation of Recombinant Genotype and No New Treponema pallidum Subspeciesendemicum Infection Among Syphilis Patients

Autoři

NODA, Angel A. (192 Kuba), Islay RODRIGUEZ (192 Kuba) a David ŠMAJS (203 Česká republika, garant, domácí)

Vydání

Sexually transmitted diseases, Philadelphia, Lippincott Williams & Wilkins, 2020, 0148-5717

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30303 Infectious Diseases

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.830

Kód RIV

RIV/00216224:14110/20:00118622

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1097/OLQ.0000000000001217

UT WoS

000574642100001

Klíčová slova anglicky

Treponema pallidumin; Cuba; Syphilis Patients

Štítky

14110513, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 29. 10. 2020 13:16, Mgr. Tereza Miškechová

Anotace

V originále

Objectives This study aimed to determine the allelic profiles ofTreponema pallidumin patients confirmed with syphilis in Cuba (2018-2019) and to explore mutations leading to macrolide and tetracycline resistance. Methods Multilocus sequence typing and polymerase chain reaction ofrrnloci (23S and 16S rDNA), followed by Sanger sequencing, were used to define the allelic profile of TPA and resistance mutations, respectively. Results Allelic profile 1.3.1 and the recombinant profile were identified, with 15.7.3 having an increased frequency. We did not detect the presence of theT. pallidumsubspeciesendemicumamong syphilis patients, as in previous reports. A high frequency of macrolide-resistant strains and the absence of mutations potentially causing tetracycline resistance were found. Conclusions Understanding the current status of treponemal infection in Cuban patients provides insights into the syphilis epidemiology.

Návaznosti

NV17-31333A, projekt VaV

Název: Vývoj nového typovacího systému pro původce syfilis, Treponema pallidum subsp. pallidum, zaměřeného na proteomické rozdíly

Citovat

NODA, Angel A., Islay RODRIGUEZ a David ŠMAJS. Genotyping of Treponema pallidumin Cuba (2018-2019): Increased Circulation of Recombinant Genotype and No New Treponema pallidum Subspeciesendemicum Infection Among Syphilis Patients. Sexually transmitted diseases. Philadelphia: Lippincott Williams & Wilkins, 2020, roč. 47, č. 10, s. "E39"-"E41", 3 s. ISSN 0148-5717. Dostupné z: https://dx.doi.org/10.1097/OLQ.0000000000001217.

@article{1685076,
   author = {Noda, Angel A. and Rodriguez, Islay and Šmajs, David},
   article_location = {Philadelphia},
   article_number = {10},
   doi = {http://dx.doi.org/10.1097/OLQ.0000000000001217},
   keywords = {Treponema pallidumin; Cuba; Syphilis Patients},
   language = {eng},
   issn = {0148-5717},
   journal = {Sexually transmitted diseases},
   title = {Genotyping of Treponema pallidumin Cuba (2018-2019): Increased Circulation of Recombinant Genotype and No New Treponema pallidum Subspeciesendemicum Infection Among Syphilis Patients},
   url = {https://journals.lww.com/stdjournal/Fulltext/2020/10000/Genotyping_of_Treponema_pallidum_in_Cuba.12.aspx},
   volume = {47},
   year = {2020}
}

TY  - JOUR
ID  - 1685076
AU  - Noda, Angel A. - Rodriguez, Islay - Šmajs, David
PY  - 2020
TI  - Genotyping of Treponema pallidumin Cuba (2018-2019): Increased Circulation of Recombinant Genotype and No New Treponema pallidum Subspeciesendemicum Infection Among Syphilis Patients
JF  - Sexually transmitted diseases
VL  - 47
IS  - 10
SP  - "E39"-"E41"
EP  - "E39"-"E41"
PB  - Lippincott Williams & Wilkins
SN  - 01485717
KW  - Treponema pallidumin
KW  - Cuba
KW  - Syphilis Patients
UR  - https://journals.lww.com/stdjournal/Fulltext/2020/10000/Genotyping_of_Treponema_pallidum_in_Cuba.12.aspx
L2  - https://journals.lww.com/stdjournal/Fulltext/2020/10000/Genotyping_of_Treponema_pallidum_in_Cuba.12.aspx
N2  - Objectives This study aimed to determine the allelic profiles ofTreponema pallidumin patients confirmed with syphilis in Cuba (2018-2019) and to explore mutations leading to macrolide and tetracycline resistance. Methods Multilocus sequence typing and polymerase chain reaction ofrrnloci (23S and 16S rDNA), followed by Sanger sequencing, were used to define the allelic profile of TPA and resistance mutations, respectively. Results Allelic profile 1.3.1 and the recombinant profile were identified, with 15.7.3 having an increased frequency. We did not detect the presence of theT. pallidumsubspeciesendemicumamong syphilis patients, as in previous reports. A high frequency of macrolide-resistant strains and the absence of mutations potentially causing tetracycline resistance were found. Conclusions Understanding the current status of treponemal infection in Cuban patients provides insights into the syphilis epidemiology.
ER  -

NODA, Angel A., Islay RODRIGUEZ a David ŠMAJS. Genotyping of Treponema pallidumin Cuba (2018-2019): Increased Circulation of Recombinant Genotype and No New Treponema pallidum Subspeciesendemicum Infection Among Syphilis Patients. \textit{Sexually transmitted diseases}. Philadelphia: Lippincott Williams \&{} Wilkins, 2020, roč.~47, č.~10, s.~''E39''-''E41'', 3 s. ISSN~0148-5717. Dostupné z: https://dx.doi.org/10.1097/OLQ.0000000000001217.

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