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@article{1686025, author = {Pazderová, Lucia and David, Tomáš and Hlinová, Veronika and Plutnar, Jan and Kotek, Jan and Lubal, Přemysl and Kubíček, Vojtěch and Hermann, Petr}, article_location = {Washington}, article_number = {12}, doi = {http://dx.doi.org/10.1021/acs.inorgchem.0c00856}, keywords = {Cyclam; Macrocyclic Lactams; Copper 64}, language = {eng}, issn = {0020-1669}, journal = {Inorganic Chemistry}, title = {Cross-Bridged Cyclam with Phosphonate and Phosphinate Pendant Arms: Chelators for Copper Radioisotopes with Fast Complexation}, url = {https://doi.org/10.1021/acs.inorgchem.0c00856}, volume = {59}, year = {2020} }
TY - JOUR ID - 1686025 AU - Pazderová, Lucia - David, Tomáš - Hlinová, Veronika - Plutnar, Jan - Kotek, Jan - Lubal, Přemysl - Kubíček, Vojtěch - Hermann, Petr PY - 2020 TI - Cross-Bridged Cyclam with Phosphonate and Phosphinate Pendant Arms: Chelators for Copper Radioisotopes with Fast Complexation JF - Inorganic Chemistry VL - 59 IS - 12 SP - 8432-8443 EP - 8432-8443 PB - American Chemical Society SN - 00201669 KW - Cyclam KW - Macrocyclic Lactams KW - Copper 64 UR - https://doi.org/10.1021/acs.inorgchem.0c00856 L2 - https://doi.org/10.1021/acs.inorgchem.0c00856 N2 - Cross-bridged cyclam derivatives bearing two phosphonate (H4L1), bis(phosphinate) (H4L2), or phosphinate (H2L3) pendant arms were synthesized and studied with respect to their application as copper radioisotope carriers in nuclear medicine. The ligands show high macrocycle basicity (pK(1) > 14) and high Cu(II) complex stability (log K = 20-24). The complexation and dissociation kinetics of the Cu(II) complexes were studied by ultraviolet-visible spectroscopy. Phosphonate Cu(II)-H4L1 and bis(phosphinate) Cu(II)-H4L2 complexes form very quickly, reaching quantitative formation within 1 s at pH similar to 6 and millimolar concentrations. Conversely, the formation of the phosphinate complex Cu(II)-H2L3 is much slower (9 min at pH similar to 6) due to the low stability of the out-of-cage reaction intermediate. All studied complexes are highly kinetically inert, showing half-lives of 120, 11, and 111 h for Cu(II)-H4L1, Cu(II)-H4L2, and Cu(II)-H2L3 complexes, respectively, in 1 M HClO4 at 90 degrees C. The high thermodynamic stability, fast formation, and extreme kinetic inertness of Cu(II) complexes indicate that phosphonate and bis(phosphinate) derivatives are promising ligands for nuclear medicine. ER -
PAZDEROVÁ, Lucia, Tomáš DAVID, Veronika HLINOVÁ, Jan PLUTNAR, Jan KOTEK, Přemysl LUBAL, Vojtěch KUBÍČEK a Petr HERMANN. Cross-Bridged Cyclam with Phosphonate and Phosphinate Pendant Arms: Chelators for Copper Radioisotopes with Fast Complexation. \textit{Inorganic Chemistry}. Washington: American Chemical Society, 2020, roč.~59, č.~12, s.~8432-8443. ISSN~0020-1669. Dostupné z: https://dx.doi.org/10.1021/acs.inorgchem.0c00856.
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