| SKLADANY, Lubomir, Marian OLTMAN, Sona FRANKOVA, Sylvia DRAZILOVA, Petr HUSA, Jan SPERL, Vaclav HEJDA, Petr URBANEK, Svetlana ADAMCOVA-SELCANOVA, Martin JANICKO, Pavol KRISTIAN, Viera KUPCOVA, Marek RAC, Ivan SCHRETER, Ladislav VIRAG, Adriana LIPTAKOVA, Miriam ONDRASOVA and Peter JARCUSKA. Chronic hepatitis C virus infection in the Czech Republic and Slovakia: an analysis of patient and virus characteristics. International Journal of Public Health. Basel (Switzerland): Springer, 2020, vol. 65, No 9, p. 1723-1735. ISSN 1661-8556. Available from: https://dx.doi.org/10.1007/s00038-020-01496-y. |
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@article{1686556,
author = {Skladany, Lubomir and Oltman, Marian and Frankova, Sona and Drazilova, Sylvia and Husa, Petr and Sperl, Jan and Hejda, Vaclav and Urbanek, Petr and AdamcovaandSelcanova, Svetlana and Janicko, Martin and Kristian, Pavol and Kupcova, Viera and Rac, Marek and Schreter, Ivan and Virag, Ladislav and Liptakova, Adriana and Ondrasova, Miriam and Jarcuska, Peter},
article_location = {Basel (Switzerland)},
article_number = {9},
doi = {http://dx.doi.org/10.1007/s00038-020-01496-y},
keywords = {Chronic HCV infection; HCV genotype; HCV liver disease; Czech Republic; Slovakia; Anti-HCV therapy},
language = {eng},
issn = {1661-8556},
journal = {International Journal of Public Health},
title = {Chronic hepatitis C virus infection in the Czech Republic and Slovakia: an analysis of patient and virus characteristics},
url = {https://link.springer.com/article/10.1007%2Fs00038-020-01496-y},
volume = {65},
year = {2020}
}
TY - JOUR
ID - 1686556
AU - Skladany, Lubomir - Oltman, Marian - Frankova, Sona - Drazilova, Sylvia - Husa, Petr - Sperl, Jan - Hejda, Vaclav - Urbanek, Petr - Adamcova-Selcanova, Svetlana - Janicko, Martin - Kristian, Pavol - Kupcova, Viera - Rac, Marek - Schreter, Ivan - Virag, Ladislav - Liptakova, Adriana - Ondrasova, Miriam - Jarcuska, Peter
PY - 2020
TI - Chronic hepatitis C virus infection in the Czech Republic and Slovakia: an analysis of patient and virus characteristics
JF - International Journal of Public Health
VL - 65
IS - 9
SP - 1723-1735
EP - 1723-1735
PB - Springer
SN - 16618556
KW - Chronic HCV infection
KW - HCV genotype
KW - HCV liver disease
KW - Czech Republic
KW - Slovakia
KW - Anti-HCV therapy
UR - https://link.springer.com/article/10.1007%2Fs00038-020-01496-y
L2 - https://link.springer.com/article/10.1007%2Fs00038-020-01496-y
N2 - Objectives The MOSAIC study gathered data on chronic hepatitis C virus (HCV) infection and its treatment in various countries worldwide. Here we summarise patient and HCV characteristics in the Czech Republic and Slovakia. Methods MOSAIC was an observational study that included patients with chronic HCV infection untreated at the time of enrolment. Study collected and descriptively analysed patient demographics, disease stage and viral characteristics. Data were collected between February 2014 to October 2014. Results Among 220 patients enrolled, 51.4% were treatment-naive. The most prevalent HCV genotype was G1 (78.4%), followed by G3 (19.7%). Higher prevalence of G1 was found in treatment-experienced patients (94.3%) compared to treatment-naive (63.4%). Most participants (67.7%) presented viral RNA load of >= 800,000 IU/mL. Liver cirrhosis was reported in 24.5% of patients. Higher HCV RNA load and duration of HCV infection correlated with the degree of liver fibrosis. Anti-HCV interferon-based treatments were initiated in 88.2% of participants. Conclusions The study confirmed significant changes in the HCV genotypes partition with G3 genotype rapidly increasing in both countries, with possible impact on the WHO eradication initiative and treatment selection.
ER -
SKLADANY, Lubomir, Marian OLTMAN, Sona FRANKOVA, Sylvia DRAZILOVA, Petr HUSA, Jan SPERL, Vaclav HEJDA, Petr URBANEK, Svetlana ADAMCOVA-SELCANOVA, Martin JANICKO, Pavol KRISTIAN, Viera KUPCOVA, Marek RAC, Ivan SCHRETER, Ladislav VIRAG, Adriana LIPTAKOVA, Miriam ONDRASOVA and Peter JARCUSKA. Chronic hepatitis C virus infection in the Czech Republic and Slovakia: an analysis of patient and virus characteristics. \textit{International Journal of Public Health}. Basel (Switzerland): Springer, 2020, vol.~65, No~9, p.~1723-1735. ISSN~1661-8556. Available from: https://dx.doi.org/10.1007/s00038-020-01496-y.
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