HARDI-ZOOMit protocol improves specificity to microstructural
changes in presymptomatic myelopathy

J 2020

HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy

LABOUNEK, René; Jan VALOŠEK; Tomáš HORÁK; Alena SVÁTKOVÁ; Petr BEDNAŘÍK et. al.

Základní údaje

Originální název

HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy

Autoři

Vydání

Scientific Reports, London, Nature Publishing Group, 2020, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.380

Kód RIV

RIV/00216224:14110/20:00116731

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1038/s41598-020-70297-3

UT WoS

000585841900010

EID Scopus

2-s2.0-85080989889

Klíčová slova anglicky

HARDI-ZOOMit protocol; presymptomatic myelopathy

Štítky

14110221, CF MAFIL, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 10. 2024 11:49, Ing. Jana Kuchtová

Anotace

V originále

Diffusion magnetic resonance imaging (dMRI) proved promising in patients with non-myelopathic degenerative cervical cord compression (NMDCCC), i.e., without clinically manifested myelopathy. Aim of the study is to present a fast multi-shell HARDI-ZOOMit dMRI protocol and validate its usability to detect microstructural myelopathy in NMDCCC patients. In 7 young healthy volunteers, 13 age-comparable healthy controls, 18 patients with mild NMDCCC and 15 patients with severe NMDCCC, the protocol provided higher signal-to-noise ratio, enhanced visualization of white/gray matter structures in microstructural maps, improved dMRI metric reproducibility, preserved sensitivity (SE = 87.88%) and increased specificity (SP = 92.31%) of control-patient group differences when compared to DTI-RESOLVE protocol (SE = 87.88%, SP = 76.92%). Of the 56 tested microstructural parameters, HARDI-ZOOMit yielded significant patient-control differences in 19 parameters, whereas in DTI-RESOLVE data, differences were observed in 10 parameters, with mostly lower robustness. Novel marker the white-gray matter diffusivity gradient demonstrated the highest separation. HARDI-ZOOMit protocol detected larger number of crossing fibers (5–15% of voxels) with physiologically plausible orientations than DTI-RESOLVE protocol (0–8% of voxels). Crossings were detected in areas of dorsal horns and anterior white commissure. HARDI-ZOOMit protocol proved to be a sensitive and practical tool for clinical quantitative spinal cord imaging.

Návaznosti

LM2018140, projekt VaV

Název: e-Infrastruktura CZ (Akronym: e-INFRA CZ)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, e-Infrastruktura CZ

NV18-04-00159, projekt VaV

Název: Využití pokročilých magneticko-rezonančních technik k odhalení patofyziologie a zlepšení diagnostiky a praktického managementu degenerativní komprese krční míchy

Investor: Ministerstvo zdravotnictví ČR, Využití pokročilých magneticko-rezonančních technik k objasnění patofyziologie a zlepšení diagnostiky a praktického managementu degenerativní komprese krční míchy

90062, velká výzkumná infrastruktura

Název: Czech-BioImaging

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Citovat

LABOUNEK, René; Jan VALOŠEK; Tomáš HORÁK; Alena SVÁTKOVÁ; Petr BEDNAŘÍK; Lubomír VOJTÍŠEK; Magda HORÁKOVÁ; Igor NESTRAŠIL; Christophe LENGLET; Julien COHEN-ADAD; Josef BEDNAŘÍK a Petr HLUŠTÍK. HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy. Scientific Reports. London: Nature Publishing Group, 2020, roč. 10, č. 1, s. 1-19. ISSN 2045-2322. Dostupné z: https://doi.org/10.1038/s41598-020-70297-3.

@article{1687183,
   author = {Labounek, René and Valošek, Jan and Horák, Tomáš and Svátková, Alena and Bednařík, Petr and Vojtíšek, Lubomír and Horáková, Magda and Nestrašil, Igor and Lenglet, Christophe and CohenandAdad, Julien and Bednařík, Josef and Hluštík, Petr},
   article_location = {London},
   article_number = {1},
   doi = {https://doi.org/10.1038/s41598-020-70297-3},
   keywords = {HARDI-ZOOMit protocol; presymptomatic myelopathy},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy},
   url = {https://www.nature.com/articles/s41598-020-70297-3},
   volume = {10},
   year = {2020}
}

TY  - JOUR
ID  - 1687183
AU  - Labounek, René - Valošek, Jan - Horák, Tomáš - Svátková, Alena - Bednařík, Petr - Vojtíšek, Lubomír - Horáková, Magda - Nestrašil, Igor - Lenglet, Christophe - Cohen-Adad, Julien - Bednařík, Josef - Hluštík, Petr
PY  - 2020
TI  - HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy
JF  - Scientific Reports
VL  - 10
IS  - 1
SP  - 1-19
EP  - 1-19
PB  - Nature Publishing Group
SN  - 20452322
KW  - HARDI-ZOOMit protocol
KW  - presymptomatic myelopathy
UR  - https://www.nature.com/articles/s41598-020-70297-3
L2  - https://www.nature.com/articles/s41598-020-70297-3
N2  - Diffusion magnetic resonance imaging (dMRI) proved promising in patients with non-myelopathic degenerative cervical cord compression (NMDCCC), i.e., without clinically manifested myelopathy. Aim of the study is to present a fast multi-shell HARDI-ZOOMit dMRI protocol and validate its usability to detect microstructural myelopathy in NMDCCC patients. In 7 young healthy volunteers, 13 age-comparable healthy controls, 18 patients with mild NMDCCC and 15 patients with severe NMDCCC, the protocol provided higher signal-to-noise ratio, enhanced visualization of white/gray matter structures in microstructural maps, improved dMRI metric reproducibility, preserved sensitivity (SE = 87.88%) and increased specificity (SP = 92.31%) of control-patient group differences when compared to DTI-RESOLVE protocol (SE = 87.88%, SP = 76.92%). Of the 56 tested microstructural parameters, HARDI-ZOOMit yielded significant patient-control differences in 19 parameters, whereas in DTI-RESOLVE data, differences were observed in 10 parameters, with mostly lower robustness. Novel marker the white-gray matter diffusivity gradient demonstrated the highest separation. HARDI-ZOOMit protocol detected larger number of crossing fibers (5–15% of voxels) with physiologically plausible orientations than DTI-RESOLVE protocol (0–8% of voxels). Crossings were detected in areas of dorsal horns and anterior white commissure. HARDI-ZOOMit protocol proved to be a sensitive and practical tool for clinical quantitative spinal cord imaging.
ER  -

LABOUNEK, René; Jan VALOŠEK; Tomáš HORÁK; Alena SVÁTKOVÁ; Petr BEDNAŘÍK; Lubomír VOJTÍŠEK; Magda HORÁKOVÁ; Igor NESTRAŠIL; Christophe LENGLET; Julien COHEN-ADAD; Josef BEDNAŘÍK a Petr HLUŠTÍK. HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy. \textit{Scientific Reports}. London: Nature Publishing Group, 2020, roč.~10, č.~1, s.~1-19. ISSN~2045-2322. Dostupné z: https://doi.org/10.1038/s41598-020-70297-3.

Přehled o publikaci