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@article{1687183,
author = {Labounek, René and Valošek, Jan and Horák, Tomáš and Svátková, Alena and Bednařík, Petr and Vojtíšek, Lubomír and Horáková, Magda and Nestrašil, Igor and Lenglet, Christophe and CohenandAdad, Julien and Bednařík, Josef and Hluštík, Petr},
article_location = {London},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-020-70297-3},
keywords = {HARDI-ZOOMit protocol; presymptomatic myelopathy},
language = {eng},
issn = {2045-2322},
journal = {Scientific Reports},
title = {HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy},
url = {https://www.nature.com/articles/s41598-020-70297-3},
volume = {10},
year = {2020}
}
TY - JOUR
ID - 1687183
AU - Labounek, René - Valošek, Jan - Horák, Tomáš - Svátková, Alena - Bednařík, Petr - Vojtíšek, Lubomír - Horáková, Magda - Nestrašil, Igor - Lenglet, Christophe - Cohen-Adad, Julien - Bednařík, Josef - Hluštík, Petr
PY - 2020
TI - HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy
JF - Scientific Reports
VL - 10
IS - 1
SP - 1-19
EP - 1-19
PB - Nature Publishing Group
SN - 20452322
KW - HARDI-ZOOMit protocol
KW - presymptomatic myelopathy
UR - https://www.nature.com/articles/s41598-020-70297-3
L2 - https://www.nature.com/articles/s41598-020-70297-3
N2 - Diffusion magnetic resonance imaging (dMRI) proved promising in patients with non-myelopathic degenerative cervical cord compression (NMDCCC), i.e., without clinically manifested myelopathy. Aim of the study is to present a fast multi-shell HARDI-ZOOMit dMRI protocol and validate its usability to detect microstructural myelopathy in NMDCCC patients. In 7 young healthy volunteers, 13 age-comparable healthy controls, 18 patients with mild NMDCCC and 15 patients with severe NMDCCC, the protocol provided higher signal-to-noise ratio, enhanced visualization of white/gray matter structures in microstructural maps, improved dMRI metric reproducibility, preserved sensitivity (SE = 87.88%) and increased specificity (SP = 92.31%) of control-patient group differences when compared to DTI-RESOLVE protocol (SE = 87.88%, SP = 76.92%). Of the 56 tested microstructural parameters, HARDI-ZOOMit yielded significant patient-control differences in 19 parameters, whereas in DTI-RESOLVE data, differences were observed in 10 parameters, with mostly lower robustness. Novel marker the white-gray matter diffusivity gradient demonstrated the highest separation. HARDI-ZOOMit protocol detected larger number of crossing fibers (5–15% of voxels) with physiologically plausible orientations than DTI-RESOLVE protocol (0–8% of voxels). Crossings were detected in areas of dorsal horns and anterior white commissure. HARDI-ZOOMit protocol proved to be a sensitive and practical tool for clinical quantitative spinal cord imaging.
ER -
LABOUNEK, René, Jan VALOŠEK, Tomáš HORÁK, Alena SVÁTKOVÁ, Petr BEDNAŘÍK, Lubomír VOJTÍŠEK, Magda HORÁKOVÁ, Igor NESTRAŠIL, Christophe LENGLET, Julien COHEN-ADAD, Josef BEDNAŘÍK a Petr HLUŠTÍK. HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy. \textit{Scientific Reports}. London: Nature Publishing Group, 2020, roč.~10, č.~1, s.~1-19. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-020-70297-3.
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