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@article{1687241,
author = {Lisicky, Ondrej and Mala, Aneta and Bednařík, Zdeněk and Novotný, Tomáš and Bursa, Jiri},
article_location = {San Francisco},
article_number = {9},
doi = {http://dx.doi.org/10.1371/journal.pone.0239447},
keywords = {carotid artery; atheroma; stiffness of wall layers},
language = {eng},
issn = {1932-6203},
journal = {Plos one},
title = {Consideration of stiffness of wall layers is decisive for patient-specific analysis of carotid artery with atheroma},
url = {https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0239447&type=printable},
volume = {15},
year = {2020}
}
TY - JOUR
ID - 1687241
AU - Lisicky, Ondrej - Mala, Aneta - Bednařík, Zdeněk - Novotný, Tomáš - Bursa, Jiri
PY - 2020
TI - Consideration of stiffness of wall layers is decisive for patient-specific analysis of carotid artery with atheroma
JF - Plos one
VL - 15
IS - 9
SP - 1-18
EP - 1-18
PB - Public Library of Science
SN - 19326203
KW - carotid artery
KW - atheroma
KW - stiffness of wall layers
UR - https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0239447&type=printable
L2 - https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0239447&type=printable
N2 - The paper deals with the impact of chosen geometric and material factors on maximal stresses in carotid atherosclerotic plaque calculated using patient-specific finite element models. These stresses are believed to be decisive for the plaque vulnerability but all applied models suffer from inaccuracy of input data, especially when obtainedin vivoonly. One hundred computational models based onex vivoMRI are used to investigate the impact of wall thickness, MRI slice thickness, lipid core and fibrous tissue stiffness, and media anisotropy on the calculated peak plaque and peak cap stresses. The investigated factors are taken as continuous in the range based on published experimental results, only the impact of anisotropy is evaluated by comparison with a corresponding isotropic model. Design of Experiment concept is applied to assess the statistical significance of these investigated factors representing uncertainties in the input data of the model. The results show that consideration of realistic properties of arterial wall in the model is decisive for the stress evaluation; assignment of properties of fibrous tissue even to media and adventitia layers as done in some studies may induce up to eightfold overestimation of peak stress. The impact of MRI slice thickness may play a key role when local thin fibrous cap is present. Anisotropy of media layer is insignificant, and the stiffness of fibrous tissue and lipid core may become significant in some combinations.
ER -
LISICKY, Ondrej, Aneta MALA, Zdeněk BEDNAŘÍK, Tomáš NOVOTNÝ a Jiri BURSA. Consideration of stiffness of wall layers is decisive for patient-specific analysis of carotid artery with atheroma. \textit{Plos one}. San Francisco: Public Library of Science, 2020, roč.~15, č.~9, s.~1-18. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0239447.
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