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@article{1688776,
author = {Komendová, Martina and Urban, Jiří},
article_location = {Amsterdam},
article_number = {MAY 10 2020},
doi = {http://dx.doi.org/10.1016/j.chroma.2020.460893},
keywords = {Dopamine; Dual-retention; Polymer monolith; Regression analysis; Retention model},
language = {eng},
issn = {0021-9673},
journal = {Journal of Chromatography A},
title = {Dual-retention mechanism of dopamine-related compounds on monolithic stationary phase with zwitterion functionality},
url = {https://doi.org/10.1016/j.chroma.2020.460893},
volume = {1618},
year = {2020}
}
TY - JOUR
ID - 1688776
AU - Komendová, Martina - Urban, Jiří
PY - 2020
TI - Dual-retention mechanism of dopamine-related compounds on monolithic stationary phase with zwitterion functionality
JF - Journal of Chromatography A
VL - 1618
IS - MAY 10 2020
SP - 1-8
EP - 1-8
PB - Elsevier
SN - 00219673
KW - Dopamine
KW - Dual-retention
KW - Polymer monolith
KW - Regression analysis
KW - Retention model
UR - https://doi.org/10.1016/j.chroma.2020.460893
L2 - https://doi.org/10.1016/j.chroma.2020.460893
N2 - Seven retention models have been selected to describe a dual-retention behavior of ten dopamine-related compounds on polymer-based monolithic stationary phase with zwitterion sulfobetaine functionality. Regression quality, as well as a statistical significance of individual regression parameters, have been evaluated. Better regression performance showed two four-parameter models when compared to threeparameter models. On the other hand, limited number of experimental points disqualified statistical robustness of four-parameter models. Among three-parameter models, retention description introduced by Horvath and Liang provided comparable quality of regression at significantly improved robustness. Multivariate analysis of the best three-parameter models provided the description of physicochemical properties of dopamine precursors and metabolites. Principal component analysis and logistic regression allowed structural characterization of dopamine-related compounds based solely on regression parameters extracted from an isocratic elution data. Both polarity and type of functional groups has been correctly assigned for 3-methoxytyramine that has not been part of an evaluation study. Among applied dual-retention models, Horvath ' s model, initially developed to describe a retention of ionic compounds on nonpolar stationary phases, provided robust regression of experimental data and allowed an extraction of structural characteristics of dopamine-related compounds.
ER -
KOMENDOVÁ, Martina a Jiří URBAN. Dual-retention mechanism of dopamine-related compounds on monolithic stationary phase with zwitterion functionality. \textit{Journal of Chromatography A}. Amsterdam: Elsevier, 2020, roč.~1618, MAY 10 2020, s.~1-8. ISSN~0021-9673. Dostupné z: https://dx.doi.org/10.1016/j.chroma.2020.460893.
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