Mitigation of Exercise Oscillatory Ventilation Score by Cardiac
Resynchronization Therapy

J 2020

Mitigation of Exercise Oscillatory Ventilation Score by Cardiac Resynchronization Therapy

ČUNDRLE, Ivan; Bruce D. JOHNSON; Robert F. REA; Christopher G. SCOTT; Virend K. SOMERS et al.

Základní údaje

Originální název

Mitigation of Exercise Oscillatory Ventilation Score by Cardiac Resynchronization Therapy

Autoři

ČUNDRLE, Ivan; Bruce D. JOHNSON; Robert F. REA; Christopher G. SCOTT; Virend K. SOMERS a Lyle J. OLSON

Vydání

JOURNAL OF CARDIAC FAILURE, PHILADELPHIA, CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS, 2020, 1071-9164

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.712

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/20:00116819

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Exercise oscillatory ventilation; heart failure; CO2 chemosensitivity; pacing

Štítky

14110122, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 11. 2020 14:07, Mgr. Tereza Miškechová

Anotace

V originále

Background: Exercise oscillatory ventilation (EOV) is a consequence of ventilatory control system instability and is commonly observed in patients with advanced heart failure (HF); it is associated with adverse prognosis. The goal of this study was to evaluate the effects of cardiac resynchronization therapy (CRT) on oscillatory ventilation as quantified by a proposed EOV score. Methods and Results: Consecutive patients with HF (N = 35) who underwent clinically indicated CRT, cardiopulmonary exercise testing and carbon dioxide (CO2) chemosensitivity by rebreathe before and 4-6 months after CRT were included in this post hoc analysis. With CRT, EOV scores improved in 22 patients (63%). In these patients, left ventricular ejection fraction, left atrial volume, brain natriuretic peptide concentration, and CO2 chemosensitivity significantly improved after CRT (P < 0.05). Furthermore, minute ventilation per unit CO2 production significantly decreased, and end-tidal CO2 increased at rest and at peak exercise post-CRT. Multiple regression analysis showed only the change of CO2 chemosensitivity to be significantly associated with the improvement of the EOV score (b = 0.64; F = 11.3; P = 0.004). In the group without EOV score improvement (n = 13), though left ventricular ejection fraction significantly increased with CRT (P = 0.015), no significant changes in ventilation or gas exchange were observed. Conclusion: The EOV score was mitigated by CRT and was associated with decreased CO2 chemosensitivity.

Citovat

ČUNDRLE, Ivan; Bruce D. JOHNSON; Robert F. REA; Christopher G. SCOTT; Virend K. SOMERS a Lyle J. OLSON. Mitigation of Exercise Oscillatory Ventilation Score by Cardiac Resynchronization Therapy. JOURNAL OF CARDIAC FAILURE. PHILADELPHIA: CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS, 2020, roč. 26, č. 10, s. 832-840. ISSN 1071-9164. Dostupné z: https://doi.org/10.1016/j.cardfail.2020.03.006.

@article{1688925,
   author = {Čundrle, Ivan and Johnson, Bruce D. and Rea, Robert F. and Scott, Christopher G. and Somers, Virend K. and Olson, Lyle J.},
   article_location = {PHILADELPHIA},
   article_number = {10},
   doi = {https://doi.org/10.1016/j.cardfail.2020.03.006},
   keywords = {Exercise oscillatory ventilation; heart failure; CO2 chemosensitivity; pacing},
   language = {eng},
   issn = {1071-9164},
   journal = {JOURNAL OF CARDIAC FAILURE},
   title = {Mitigation of Exercise Oscillatory Ventilation Score by Cardiac Resynchronization Therapy},
   url = {https://www.sciencedirect.com/science/article/pii/S1071916419307547?via%3Dihub},
   volume = {26},
   year = {2020}
}

TY  - JOUR
ID  - 1688925
AU  - Čundrle, Ivan - Johnson, Bruce D. - Rea, Robert F. - Scott, Christopher G. - Somers, Virend K. - Olson, Lyle J.
PY  - 2020
TI  - Mitigation of Exercise Oscillatory Ventilation Score by Cardiac Resynchronization Therapy
JF  - JOURNAL OF CARDIAC FAILURE
VL  - 26
IS  - 10
SP  - 832-840
EP  - 832-840
PB  - CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
SN  - 10719164
KW  - Exercise oscillatory ventilation
KW  - heart failure
KW  - CO2 chemosensitivity
KW  - pacing
UR  - https://www.sciencedirect.com/science/article/pii/S1071916419307547?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S1071916419307547?via%3Dihub
N2  - Background: Exercise oscillatory ventilation (EOV) is a consequence of ventilatory control system instability and is commonly observed in patients with advanced heart failure (HF); it is associated with adverse prognosis. The goal of this study was to evaluate the effects of cardiac resynchronization therapy (CRT) on oscillatory ventilation as quantified by a proposed EOV score. Methods and Results: Consecutive patients with HF (N = 35) who underwent clinically indicated CRT, cardiopulmonary exercise testing and carbon dioxide (CO2) chemosensitivity by rebreathe before and 4-6 months after CRT were included in this post hoc analysis. With CRT, EOV scores improved in 22 patients (63%). In these patients, left ventricular ejection fraction, left atrial volume, brain natriuretic peptide concentration, and CO2 chemosensitivity significantly improved after CRT (P < 0.05). Furthermore, minute ventilation per unit CO2 production significantly decreased, and end-tidal CO2 increased at rest and at peak exercise post-CRT. Multiple regression analysis showed only the change of CO2 chemosensitivity to be significantly associated with the improvement of the EOV score (b = 0.64; F = 11.3; P = 0.004). In the group without EOV score improvement (n = 13), though left ventricular ejection fraction significantly increased with CRT (P = 0.015), no significant changes in ventilation or gas exchange were observed. Conclusion: The EOV score was mitigated by CRT and was associated with decreased CO2 chemosensitivity.
ER  -

ČUNDRLE, Ivan; Bruce D. JOHNSON; Robert F. REA; Christopher G. SCOTT; Virend K. SOMERS a Lyle J. OLSON. Mitigation of Exercise Oscillatory Ventilation Score by Cardiac Resynchronization Therapy. \textit{JOURNAL OF CARDIAC FAILURE}. PHILADELPHIA: CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS, 2020, roč.~26, č.~10, s.~832-840. ISSN~1071-9164. Dostupné z: https://doi.org/10.1016/j.cardfail.2020.03.006.

Přehled o publikaci