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@article{1689236,
author = {Kýr, Michal and Klement, Giannoula and Zdražilová Dubská, Lenka and Demlová, Regina and Valík, Dalibor and Slabý, Ondřej and Slavc, Irene and Štěrba, Jaroslav},
article_location = {Laussane},
article_number = {March 2020},
doi = {http://dx.doi.org/10.3389/fonc.2020.00377},
keywords = {Pediatric Oncology; Immune Therapies},
language = {eng},
issn = {2234-943X},
journal = {Frontiers in Oncology},
title = {Editorial: Precision/Personalized Pediatric Oncology and Immune Therapies: Rather Customize Than Randomize},
url = {https://www.frontiersin.org/articles/10.3389/fonc.2020.00377/full},
volume = {10},
year = {2020}
}
TY - JFULL
ID - 1689236
AU - Kýr, Michal - Klement, Giannoula - Zdražilová Dubská, Lenka - Demlová, Regina - Valík, Dalibor - Slabý, Ondřej - Slavc, Irene - Štěrba, Jaroslav
PY - 2020
TI - Editorial: Precision/Personalized Pediatric Oncology and Immune Therapies: Rather Customize Than Randomize
JF - Frontiers in Oncology
VL - 10
IS - March 2020
SP - 1-4
EP - 1-4
PB - Frontiers
SN - 2234943X
KW - Pediatric Oncology
KW - Immune Therapies
UR - https://www.frontiersin.org/articles/10.3389/fonc.2020.00377/full
L2 - https://www.frontiersin.org/articles/10.3389/fonc.2020.00377/full
N2 - Personalization of treatment based on biological markers is being utilized in clinical medicine with increasing frequency. This trend, despite an effort to identify possible common patterns, reflects the reality that no two patients are alike, and no single clinical course is identical; not even within a group of seemingly similar patients. There are numerous clinical variations related to host or environment-dependent factors. Numerous examples of these interpersonal differences have been recognized with drugs such as pain-control medications, heart medications, or antimicrobials. The differences have been attributed to increased pharmacometabolic capacity, to different individual microbiomes and to genetic differences between individuals (2). The latter has led to development of an entirely new specialty—pharmacogenomics. While this clinical heterogeneity is well-appreciated in most major medical specialties, clinical oncology seems to represent, surprisingly enough, one of the exceptions.
ER -
KÝR, Michal, Giannoula KLEMENT, Lenka ZDRAŽILOVÁ DUBSKÁ, Regina DEMLOVÁ, Dalibor VALÍK, Ondřej SLABÝ, Irene SLAVC a Jaroslav ŠTĚRBA. Editorial: Precision/Personalized Pediatric Oncology and Immune Therapies: Rather Customize Than Randomize. \textit{Frontiers in Oncology}. Laussane: Frontiers, 2020, roč.~10, March 2020, s.~1-4. ISSN~2234-943X. Dostupné z: https://dx.doi.org/10.3389/fonc.2020.00377.
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