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@article{1692161,
author = {Kaiser, Karol and Bryja, Vítězslav},
article_location = {Basel},
article_number = {13},
doi = {http://dx.doi.org/10.3390/ijms21134760},
keywords = {cerebrospinal fluid; choroid plexus; secretion},
language = {eng},
issn = {1422-0067},
journal = {International Journal of Molecular Sciences},
title = {Choroid Plexus: The Orchestrator of Long-Range Signalling Within the CNS},
url = {https://doi.org/10.3390/ijms21134760},
volume = {21},
year = {2020}
}
TY - JOUR
ID - 1692161
AU - Kaiser, Karol - Bryja, Vítězslav
PY - 2020
TI - Choroid Plexus: The Orchestrator of Long-Range Signalling Within the CNS
JF - International Journal of Molecular Sciences
VL - 21
IS - 13
SP - 1-21
EP - 1-21
PB - MDPI
SN - 14220067
KW - cerebrospinal fluid
KW - choroid plexus
KW - secretion
UR - https://doi.org/10.3390/ijms21134760
L2 - https://doi.org/10.3390/ijms21134760
N2 - Cerebrospinal fluid (CSF) is the liquid that fills the brain ventricles. CSF represents not only a mechanical brain protection but also a rich source of signalling factors modulating diverse processes during brain development and adulthood. The choroid plexus (CP) is a major source of CSF and as such it has recently emerged as an important mediator of extracellular signalling within the brain. Growing interest in the CP revealed its capacity to release a broad variety of bioactive molecules that, via CSF, regulate processes across the whole central nervous system (CNS). Moreover, CP has been also recognized as a sensor, responding to altered composition of CSF associated with changes in the patterns of CNS activity. In this review, we summarize the recent advances in our understanding of the CP as a signalling centre that mediates long-range communication in the CNS. By providing a detailed account of the CP secretory repertoire, we describe how the CP contributes to the regulation of the extracellular environment-in the context of both the embryonal as well as the adult CNS. We highlight the role of the CP as an important regulator of CNS function that acts via CSF-mediated signalling. Further studies of CP-CSF signalling hold the potential to provide key insights into the biology of the CNS, with implications for better understanding and treatment of neuropathological conditions.
ER -
KAISER, Karol a Vítězslav BRYJA. Choroid Plexus: The Orchestrator of Long-Range Signalling Within the CNS. \textit{International Journal of Molecular Sciences}. Basel: MDPI, 2020, roč.~21, č.~13, s.~1-21. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms21134760.
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