MicroRNAs in the Molecular Pathology of Gliomas

C 2014

MicroRNAs in the Molecular Pathology of Gliomas

ŠÁNA, Jiří, Andrej BEŠŠE a ondřej SLABÝ

Základní údaje

Originální název

MicroRNAs in the Molecular Pathology of Gliomas

Autoři

ŠÁNA, Jiří, Andrej BEŠŠE a ondřej SLABÝ

Vydání

1. vyd. Vienna, Glioma Cell Biology, od s. 77-116, 39 s. 2014

Nakladatel

Springer, Vienna

Další údaje

Jazyk

angličtina

Typ výsledku

Kapitola resp. kapitoly v odborné knize

Obor

30204 Oncology

Stát vydavatele

Rakousko

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

elektronická verze "online"

Odkazy

URL

Organizační jednotka

Středoevropský technologický institut

ISBN

978-3-7091-1430-8

DOI

http://dx.doi.org/10.1007/978-3-7091-1431-5_4

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 11. 2020 13:53, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

MicroRNAs (miRNAs) are endogenously expressed small noncoding RNAs that act as posttranscriptional regulators of gene expression. Dysregulation of these molecules has been observed in many types of cancers. Altered expression levels of several miRNAs were identified also in gliomas. It was been frequently shown that miRNAs are involved in core signaling pathways, which play key roles in cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis, and stem cell behavior. Therefore, miRNAs have a great potential to act as new class of diagnostic, prognostic, and predictive biomarkers as well as promising therapeutic targets in gliomas. Here, we summarize the current knowledge about miRNAs significance in glioma molecular pathology, with special focus on their involvement in core signaling pathways, their roles in drug resistance, and their potential clinical implications.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Citovat

ŠÁNA, Jiří, Andrej BEŠŠE a ondřej SLABÝ. MicroRNAs in the Molecular Pathology of Gliomas. Online. In Sedo A., Mentlein R. Glioma Cell Biology. 1. vyd. Vienna: Springer, Vienna, 2014, s. 77-116, 39 s. ISBN 978-3-7091-1430-8. Dostupné z: https://dx.doi.org/10.1007/978-3-7091-1431-5_4.

@inbook{1692177,
   author = {Šána, Jiří and Bešše, Andrej and slabý, ondřej},
   address = {Vienna},
   booktitle = {Glioma Cell Biology},
   doi = {http://dx.doi.org/10.1007/978-3-7091-1431-5_4},
   edition = {1.},
   editor = {Sedo A., Mentlein R.},
   howpublished = {elektronická verze "online"},
   language = {eng},
   location = {Vienna},
   isbn = {978-3-7091-1430-8},
   pages = {77-116},
   publisher = {Springer, Vienna},
   title = {MicroRNAs in the Molecular Pathology of Gliomas},
   url = {https://link.springer.com/chapter/10.1007/978-3-7091-1431-5_4#citeas},
   year = {2014}
}

TY  - CHAP
ID  - 1692177
AU  - Šána, Jiří - Bešše, Andrej - slabý, ondřej
PY  - 2014
TI  - MicroRNAs in the Molecular Pathology of Gliomas
PB  - Springer, Vienna
CY  - Vienna
SN  - 9783709114308
UR  - https://link.springer.com/chapter/10.1007/978-3-7091-1431-5_4#citeas
N2  - MicroRNAs (miRNAs) are endogenously expressed small noncoding RNAs that act as posttranscriptional regulators of gene expression. Dysregulation of these molecules has been observed in many types of cancers. Altered expression levels of several miRNAs were identified also in gliomas. It was been frequently shown that miRNAs are involved in core signaling pathways, which play key roles in cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis, and stem cell behavior. Therefore, miRNAs have a great potential to act as new class of diagnostic, prognostic, and predictive biomarkers as well as promising therapeutic targets in gliomas. Here, we summarize the current knowledge about miRNAs significance in glioma molecular pathology, with special focus on their involvement in core signaling pathways, their roles in drug resistance, and their potential clinical implications.
ER  -

ŠÁNA, Jiří, Andrej BEŠŠE a ondřej SLABÝ. MicroRNAs in the Molecular Pathology of Gliomas. Online. In Sedo A., Mentlein R. \textit{Glioma Cell Biology}. 1. vyd. Vienna: Springer, Vienna, 2014, s.~77-116, 39 s. ISBN~978-3-7091-1430-8. Dostupné z: https://dx.doi.org/10.1007/978-3-7091-1431-5\_{}4.

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