Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and
Therapeutic Potential

J 2020

Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential

MARTÍN MOYANO, Paula; Václav NĚMEC a Kamil PARUCH

Základní údaje

Originální název

Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential

Autoři

MARTÍN MOYANO, Paula; Václav NĚMEC a Kamil PARUCH

Vydání

International Journal of Molecular Sciences, Basel, Multidisciplinary Digital Publishing Institute, 2020, 1422-0067

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10401 Organic chemistry

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/20:00116980

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

CLK; cdc-like kinase; inhibitor; chemical biology; tool compound; chemical probe; T3; SGC-CLK-1; MU1210; SM08502

Štítky

14313010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 31. 8. 2021 16:28, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Protein kinases represent a very pharmacologically attractive class of targets; however, some members of the family still remain rather unexplored. The biology and therapeutic potential of cdc-like kinases (CLKs) have been explored mainly over the last decade and the first CLK inhibitor, compound SM08502, entered clinical trials only recently. This review summarizes the biological roles and therapeutic potential of CLKs and their heretofore published small-molecule inhibitors, with a focus on the compounds' potential to be utilized as quality chemical biology probes.

Návaznosti

EF16_025/0007381, projekt VaV

Název: Preklinická progrese nových organických sloučenin s cílenou biologickou aktivitou

LM2015063, projekt VaV

Název: Národní infrastruktura chemické biologie (Akronym: CZ-OPENSCREEN)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CZ-OPENSCREEN: National Infrastructure for Chemical Biology

Citovat

MARTÍN MOYANO, Paula; Václav NĚMEC a Kamil PARUCH. Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2020, roč. 21, č. 20, s. 1-31. ISSN 1422-0067. Dostupné z: https://doi.org/10.3390/ijms21207549.

@article{1695616,
   author = {Martín Moyano, Paula and Němec, Václav and Paruch, Kamil},
   article_location = {Basel},
   article_number = {20},
   doi = {https://doi.org/10.3390/ijms21207549},
   keywords = {CLK; cdc-like kinase; inhibitor; chemical biology; tool compound; chemical probe; T3; SGC-CLK-1; MU1210; SM08502},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential},
   url = {https://doi.org/10.3390/ijms21207549},
   volume = {21},
   year = {2020}
}

TY  - JOUR
ID  - 1695616
AU  - Martín Moyano, Paula - Němec, Václav - Paruch, Kamil
PY  - 2020
TI  - Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential
JF  - International Journal of Molecular Sciences
VL  - 21
IS  - 20
SP  - 1-31
EP  - 1-31
PB  - Multidisciplinary Digital Publishing Institute
SN  - 14220067
KW  - CLK
KW  - cdc-like kinase
KW  - inhibitor
KW  - chemical biology
KW  - tool compound
KW  - chemical probe
KW  - T3
KW  - SGC-CLK-1
KW  - MU1210
KW  - SM08502
UR  - https://doi.org/10.3390/ijms21207549
L2  - https://doi.org/10.3390/ijms21207549
N2  - Protein kinases represent a very pharmacologically attractive class of targets; however, some members of the family still remain rather unexplored. The biology and therapeutic potential of cdc-like kinases (CLKs) have been explored mainly over the last decade and the first CLK inhibitor, compound SM08502, entered clinical trials only recently. This review summarizes the biological roles and therapeutic potential of CLKs and their heretofore published small-molecule inhibitors, with a focus on the compounds' potential to be utilized as quality chemical biology probes.
ER  -

MARTÍN MOYANO, Paula; Václav NĚMEC a Kamil PARUCH. Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2020, roč.~21, č.~20, s.~1-31. ISSN~1422-0067. Dostupné z: https://doi.org/10.3390/ijms21207549.

Přehled o publikaci