KOMENDOVÁ, Martina, Suhas NAWADA, Radovan METELKA, Peter J. SCHOENMAKERS a Jiří URBAN. Multichannel separation device with parallel electrochemical detection. Journal of Chromatography A. Amsterdam: Elsevier, 2020, roč. 1610, JAN 11 2020, s. 1-9. ISSN 0021-9673. Dostupné z: https://dx.doi.org/10.1016/j.chroma.2019.460537. |
Další formáty:
BibTeX
LaTeX
RIS
@article{1698696, author = {Komendová, Martina and Nawada, Suhas and Metelka, Radovan and Schoenmakers, Peter J. and Urban, Jiří}, article_location = {Amsterdam}, article_number = {JAN 11 2020}, doi = {http://dx.doi.org/10.1016/j.chroma.2019.460537}, keywords = {3D printing; Multi-channel device; Dopamine metabolism; Electrochemical detection; Polymer monoliths; Titanium}, language = {eng}, issn = {0021-9673}, journal = {Journal of Chromatography A}, title = {Multichannel separation device with parallel electrochemical detection}, url = {https://doi.org/10.1016/j.chroma.2019.460537}, volume = {1610}, year = {2020} }
TY - JOUR ID - 1698696 AU - Komendová, Martina - Nawada, Suhas - Metelka, Radovan - Schoenmakers, Peter J. - Urban, Jiří PY - 2020 TI - Multichannel separation device with parallel electrochemical detection JF - Journal of Chromatography A VL - 1610 IS - JAN 11 2020 SP - 1-9 EP - 1-9 PB - Elsevier SN - 00219673 KW - 3D printing KW - Multi-channel device KW - Dopamine metabolism KW - Electrochemical detection KW - Polymer monoliths KW - Titanium UR - https://doi.org/10.1016/j.chroma.2019.460537 L2 - https://doi.org/10.1016/j.chroma.2019.460537 N2 - A device with four parallel channels was designed and manufactured by 3D printing in titanium. A simple experimental setup allowed splitting of the mobile phase in four parallel streams, such that a single sample could be analysed four times simultaneously. The four capillary channels were filled with a monolithic stationary phase, prepared using a zwitterionic functional monomer in combination with various dimethacrylate cross-linkers. The resulting stationary phases were applicable in both reversed-phase and hydrophilic-interaction retention mechanisms. The mobile-phase composition was optimized by means of a window diagram so as to obtain the highest possible resolution of dopamine precursors and metabolites on all columns. Miniaturized electrochemical detectors with carbon fibres as working electrodes and silver micro-wires as reference electrodes were integrated in the device at the end of each column. Experimental separations were successfully compared with those predicted by a three-parameter retention model. Finally, dopamine was determined in human urine to further confirm applicability of the developed device. ER -
KOMENDOVÁ, Martina, Suhas NAWADA, Radovan METELKA, Peter J. SCHOENMAKERS a Jiří URBAN. Multichannel separation device with parallel electrochemical detection. \textit{Journal of Chromatography A}. Amsterdam: Elsevier, 2020, roč.~1610, JAN 11 2020, s.~1-9. ISSN~0021-9673. Dostupné z: https://dx.doi.org/10.1016/j.chroma.2019.460537.
|