| KOMENDOVÁ, Martina, Suhas NAWADA, Radovan METELKA, Peter J. SCHOENMAKERS a Jiří URBAN. Multichannel separation device with parallel electrochemical detection. Journal of Chromatography A. Amsterdam: Elsevier, 2020, roč. 1610, JAN 11 2020, s. 1-9. ISSN 0021-9673. Dostupné z: https://dx.doi.org/10.1016/j.chroma.2019.460537. |
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@article{1698696,
author = {Komendová, Martina and Nawada, Suhas and Metelka, Radovan and Schoenmakers, Peter J. and Urban, Jiří},
article_location = {Amsterdam},
article_number = {JAN 11 2020},
doi = {http://dx.doi.org/10.1016/j.chroma.2019.460537},
keywords = {3D printing; Multi-channel device; Dopamine metabolism; Electrochemical detection; Polymer monoliths; Titanium},
language = {eng},
issn = {0021-9673},
journal = {Journal of Chromatography A},
title = {Multichannel separation device with parallel electrochemical detection},
url = {https://doi.org/10.1016/j.chroma.2019.460537},
volume = {1610},
year = {2020}
}
TY - JOUR
ID - 1698696
AU - Komendová, Martina - Nawada, Suhas - Metelka, Radovan - Schoenmakers, Peter J. - Urban, Jiří
PY - 2020
TI - Multichannel separation device with parallel electrochemical detection
JF - Journal of Chromatography A
VL - 1610
IS - JAN 11 2020
SP - 1-9
EP - 1-9
PB - Elsevier
SN - 00219673
KW - 3D printing
KW - Multi-channel device
KW - Dopamine metabolism
KW - Electrochemical detection
KW - Polymer monoliths
KW - Titanium
UR - https://doi.org/10.1016/j.chroma.2019.460537
L2 - https://doi.org/10.1016/j.chroma.2019.460537
N2 - A device with four parallel channels was designed and manufactured by 3D printing in titanium. A simple experimental setup allowed splitting of the mobile phase in four parallel streams, such that a single sample could be analysed four times simultaneously. The four capillary channels were filled with a monolithic stationary phase, prepared using a zwitterionic functional monomer in combination with various dimethacrylate cross-linkers. The resulting stationary phases were applicable in both reversed-phase and hydrophilic-interaction retention mechanisms. The mobile-phase composition was optimized by means of a window diagram so as to obtain the highest possible resolution of dopamine precursors and metabolites on all columns. Miniaturized electrochemical detectors with carbon fibres as working electrodes and silver micro-wires as reference electrodes were integrated in the device at the end of each column. Experimental separations were successfully compared with those predicted by a three-parameter retention model. Finally, dopamine was determined in human urine to further confirm applicability of the developed device.
ER -
KOMENDOVÁ, Martina, Suhas NAWADA, Radovan METELKA, Peter J. SCHOENMAKERS a Jiří URBAN. Multichannel separation device with parallel electrochemical detection. \textit{Journal of Chromatography A}. Amsterdam: Elsevier, 2020, roč.~1610, JAN 11 2020, s.~1-9. ISSN~0021-9673. Dostupné z: https://dx.doi.org/10.1016/j.chroma.2019.460537.
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