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@article{1703236,
author = {Hortová Kohoutková, Marcela and Lázničková, Petra and Frič, Jan},
article_location = {Hoboken},
article_number = {2},
doi = {http://dx.doi.org/10.1002/bies.202000067},
keywords = {energy demand; immune-cell polarization; immunometabolism; nutrient availability},
language = {eng},
issn = {0265-9247},
journal = {BioEssays},
title = {How immune-cell fate and function are determined by metabolic pathway choice The bioenergetics underlying the immune response},
url = {https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bies.202000067},
volume = {43},
year = {2021}
}
TY - JOUR
ID - 1703236
AU - Hortová Kohoutková, Marcela - Lázničková, Petra - Frič, Jan
PY - 2021
TI - How immune-cell fate and function are determined by metabolic pathway choice The bioenergetics underlying the immune response
JF - BioEssays
VL - 43
IS - 2
SP - 1-15
EP - 1-15
PB - Wiley
SN - 02659247
KW - energy demand
KW - immune-cell polarization
KW - immunometabolism
KW - nutrient availability
UR - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bies.202000067
L2 - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bies.202000067
N2 - Immune cells are highly dynamic in their response to the tissue environment. Most immune cells rapidly change their metabolic profile to obtain sufficient energy to engage in defensive or homeostatic processes. Such "immunometabolism" is governed through intermediate metabolites, and has a vital role in regulating immune-cell function. The underlying metabolic reactions are shaped by the abundance and accessibility of specific nutrients, as well as the overall metabolic status of the host. Here, we discuss how different immune-cell types gain a sufficient energy supply. We then explain how immune cells perform various functions under challenged conditions and expend energy to sustain homeostasis. Finally, we speculate on how the immune-cell metabolic profile might be modulated in health and disease, by manipulating nutrient availability. By such intervention, the recovery of patient with dysregulated immune system responses might be sped up and the fitness of an individual efficiently restored.
ER -
HORTOVÁ KOHOUTKOVÁ, Marcela, Petra LÁZNIČKOVÁ a Jan FRIČ. How immune-cell fate and function are determined by metabolic pathway choice The bioenergetics underlying the immune response. \textit{BioEssays}. Hoboken: Wiley, 2021, roč.~43, č.~2, s.~1-15. ISSN~0265-9247. Dostupné z: https://dx.doi.org/10.1002/bies.202000067.
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