How immune-cell fate and function are determined by metabolic
pathway choice The bioenergetics underlying the immune response

J 2021

How immune-cell fate and function are determined by metabolic pathway choice The bioenergetics underlying the immune response

HORTOVÁ KOHOUTKOVÁ, Marcela, Petra LÁZNIČKOVÁ a Jan FRIČ

Základní údaje

Originální název

How immune-cell fate and function are determined by metabolic pathway choice The bioenergetics underlying the immune response

Autoři

HORTOVÁ KOHOUTKOVÁ, Marcela (203 Česká republika), Petra LÁZNIČKOVÁ (203 Česká republika, domácí) a Jan FRIČ (203 Česká republika, garant)

Vydání

BioEssays, Hoboken, Wiley, 2021, 0265-9247

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.653

Kód RIV

RIV/00216224:14110/21:00120840

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1002/bies.202000067

UT WoS

000589588300001

Klíčová slova anglicky

energy demand; immune-cell polarization; immunometabolism; nutrient availability

Štítky

14110513, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 9. 2022 11:48, Mgr. Tereza Miškechová

Anotace

V originále

Immune cells are highly dynamic in their response to the tissue environment. Most immune cells rapidly change their metabolic profile to obtain sufficient energy to engage in defensive or homeostatic processes. Such "immunometabolism" is governed through intermediate metabolites, and has a vital role in regulating immune-cell function. The underlying metabolic reactions are shaped by the abundance and accessibility of specific nutrients, as well as the overall metabolic status of the host. Here, we discuss how different immune-cell types gain a sufficient energy supply. We then explain how immune cells perform various functions under challenged conditions and expend energy to sustain homeostasis. Finally, we speculate on how the immune-cell metabolic profile might be modulated in health and disease, by manipulating nutrient availability. By such intervention, the recovery of patient with dysregulated immune system responses might be sped up and the fitness of an individual efficiently restored.

Návaznosti

MUNI/A/1325/2020, interní kód MU

Název: Biomedicínské vědy

Investor: Masarykova univerzita, Biomedicínské vědy

Citovat

HORTOVÁ KOHOUTKOVÁ, Marcela, Petra LÁZNIČKOVÁ a Jan FRIČ. How immune-cell fate and function are determined by metabolic pathway choice The bioenergetics underlying the immune response. BioEssays. Hoboken: Wiley, 2021, roč. 43, č. 2, s. 1-15. ISSN 0265-9247. Dostupné z: https://dx.doi.org/10.1002/bies.202000067.

@article{1703236,
   author = {Hortová Kohoutková, Marcela and Lázničková, Petra and Frič, Jan},
   article_location = {Hoboken},
   article_number = {2},
   doi = {http://dx.doi.org/10.1002/bies.202000067},
   keywords = {energy demand; immune-cell polarization; immunometabolism; nutrient availability},
   language = {eng},
   issn = {0265-9247},
   journal = {BioEssays},
   title = {How immune-cell fate and function are determined by metabolic pathway choice The bioenergetics underlying the immune response},
   url = {https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bies.202000067},
   volume = {43},
   year = {2021}
}

TY  - JOUR
ID  - 1703236
AU  - Hortová Kohoutková, Marcela - Lázničková, Petra - Frič, Jan
PY  - 2021
TI  - How immune-cell fate and function are determined by metabolic pathway choice The bioenergetics underlying the immune response
JF  - BioEssays
VL  - 43
IS  - 2
SP  - 1-15
EP  - 1-15
PB  - Wiley
SN  - 02659247
KW  - energy demand
KW  - immune-cell polarization
KW  - immunometabolism
KW  - nutrient availability
UR  - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bies.202000067
L2  - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bies.202000067
N2  - Immune cells are highly dynamic in their response to the tissue environment. Most immune cells rapidly change their metabolic profile to obtain sufficient energy to engage in defensive or homeostatic processes. Such "immunometabolism" is governed through intermediate metabolites, and has a vital role in regulating immune-cell function. The underlying metabolic reactions are shaped by the abundance and accessibility of specific nutrients, as well as the overall metabolic status of the host. Here, we discuss how different immune-cell types gain a sufficient energy supply. We then explain how immune cells perform various functions under challenged conditions and expend energy to sustain homeostasis. Finally, we speculate on how the immune-cell metabolic profile might be modulated in health and disease, by manipulating nutrient availability. By such intervention, the recovery of patient with dysregulated immune system responses might be sped up and the fitness of an individual efficiently restored.
ER  -

HORTOVÁ KOHOUTKOVÁ, Marcela, Petra LÁZNIČKOVÁ a Jan FRIČ. How immune-cell fate and function are determined by metabolic pathway choice The bioenergetics underlying the immune response. \textit{BioEssays}. Hoboken: Wiley, 2021, roč.~43, č.~2, s.~1-15. ISSN~0265-9247. Dostupné z: https://dx.doi.org/10.1002/bies.202000067.

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