Light-Activated Peptide-Based Materials for Sutureless Wound
Closure

J 2019

Light-Activated Peptide-Based Materials for Sutureless Wound Closure

MCTIERNAN, CD; DC CORTES; C LAZURKO; S AMRANI; R ROSALES-ROJAS et al.

Základní údaje

Originální název

Light-Activated Peptide-Based Materials for Sutureless Wound Closure

Autoři

MCTIERNAN, CD; DC CORTES; C LAZURKO; S AMRANI; R ROSALES-ROJAS; M ZUNIGA-BUSTOS; Veronika SEDLÁKOVÁ; H POBLETE; K STAMPLECOSKIE; EJ SUURONEN a EI ALARCON

Vydání

ACS APPLIED MATERIALS & INTERFACES, WASHINGTON, AMER CHEMICAL SOC, 2019, 1944-8244

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 8.758

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1021/acsami.9b18891

UT WoS

000501620700009

Klíčová slova anglicky

tissue photobonding; Rose Bengal; collagen; peptide; wound healing

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 1. 2022 10:05, MUDr. Veronika Sedláková, Ph.D.

Anotace

V originále

Using chemically modified extracellular matrix proteins, such as collagen, in combination with light for tissue bonding reduces inflammation and minimizes scarring. However, full length animal or recombinant human collagen proteins are difficult to isolate/produce. Thus, short biomimetic collagen peptides with properties equivalent to collagen at both structural and functional levels may be ideal building blocks for the development of remotely triggered adhesives and fillers. In this work, the conjugation of self-assembling collagen-like peptides to acrylate functionalized polyethylene glycol units yielded adhesive filler materials activated by visible light through the incorporation of a photosensitizer. When tested in a murine skin wound model, the photoactivated adhesives showed reduced scar formation and promoted epithelial regeneration.

Citovat

MCTIERNAN, CD; DC CORTES; C LAZURKO; S AMRANI; R ROSALES-ROJAS; M ZUNIGA-BUSTOS; Veronika SEDLÁKOVÁ; H POBLETE; K STAMPLECOSKIE; EJ SUURONEN a EI ALARCON. Light-Activated Peptide-Based Materials for Sutureless Wound Closure. ACS APPLIED MATERIALS & INTERFACES. WASHINGTON: AMER CHEMICAL SOC, 2019, roč. 11, č. 48, s. 45007-45015. ISSN 1944-8244. Dostupné z: https://doi.org/10.1021/acsami.9b18891.

@article{1703797,
   author = {McTiernan, CD and Cortes, DC and Lazurko, C and Amrani, S and RosalesandRojas, R and ZunigaandBustos, M and Sedláková, Veronika and Poblete, H and Stamplecoskie, K and Suuronen, EJ and Alarcon, EI},
   article_location = {WASHINGTON},
   article_number = {48},
   doi = {https://doi.org/10.1021/acsami.9b18891},
   keywords = {tissue photobonding; Rose Bengal; collagen; peptide; wound healing},
   language = {eng},
   issn = {1944-8244},
   journal = {ACS APPLIED MATERIALS & INTERFACES},
   title = {Light-Activated Peptide-Based Materials for Sutureless Wound Closure},
   volume = {11},
   year = {2019}
}

TY  - JOUR
ID  - 1703797
AU  - McTiernan, CD - Cortes, DC - Lazurko, C - Amrani, S - Rosales-Rojas, R - Zuniga-Bustos, M - Sedláková, Veronika - Poblete, H - Stamplecoskie, K - Suuronen, EJ - Alarcon, EI
PY  - 2019
TI  - Light-Activated Peptide-Based Materials for Sutureless Wound Closure
JF  - ACS APPLIED MATERIALS & INTERFACES
VL  - 11
IS  - 48
SP  - 45007-45015
EP  - 45007-45015
PB  - AMER CHEMICAL SOC
SN  - 19448244
KW  - tissue photobonding
KW  - Rose Bengal
KW  - collagen
KW  - peptide
KW  - wound healing
N2  - Using chemically modified extracellular matrix proteins, such as collagen, in combination with light for tissue bonding reduces inflammation and minimizes scarring. However, full length animal or recombinant human collagen proteins are difficult to isolate/produce. Thus, short biomimetic collagen peptides with properties equivalent to collagen at both structural and functional levels may be ideal building blocks for the development of remotely triggered adhesives and fillers. In this work, the conjugation of self-assembling collagen-like peptides to acrylate functionalized polyethylene glycol units yielded adhesive filler materials activated by visible light through the incorporation of a photosensitizer. When tested in a murine skin wound model, the photoactivated adhesives showed reduced scar formation and promoted epithelial regeneration.
ER  -

MCTIERNAN, CD; DC CORTES; C LAZURKO; S AMRANI; R ROSALES-ROJAS; M ZUNIGA-BUSTOS; Veronika SEDLÁKOVÁ; H POBLETE; K STAMPLECOSKIE; EJ SUURONEN a EI ALARCON. Light-Activated Peptide-Based Materials for Sutureless Wound Closure. \textit{ACS APPLIED MATERIALS \&{}amp; INTERFACES}. WASHINGTON: AMER CHEMICAL SOC, 2019, roč.~11, č.~48, s.~45007-45015. ISSN~1944-8244. Dostupné z: https://doi.org/10.1021/acsami.9b18891.

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