Collagen-Based Microcapsules As Therapeutic Materials for Stem
Cell Therapies in Infarcted Myocardium

J 2020

Collagen-Based Microcapsules As Therapeutic Materials for Stem Cell Therapies in Infarcted Myocardium

JACQUES, E; K HOSOYAMA; B BINIAM; CE CIMENCI; Veronika SEDLÁKOVÁ et al.

Základní údaje

Originální název

Collagen-Based Microcapsules As Therapeutic Materials for Stem Cell Therapies in Infarcted Myocardium

Autoři

JACQUES, E; K HOSOYAMA; B BINIAM; CE CIMENCI; Veronika SEDLÁKOVÁ; AJ STEEVES; F VARIOLA; DR DAVIS; DJ STEWART; EJ SUURONEN a EI ALARCON

Vydání

ACS BIOMATERIALS SCIENCE & ENGINEERING, WASHINGTON, AMER CHEMICAL SOC, 2020, 2373-9878

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.749

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1021/acsbiomaterials.0c00245

UT WoS

000562119500026

Klíčová slova anglicky

cell encapsulation; tissue regeneration; biomimetic matrix; myocardial infarction

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 31. 3. 2022 08:07, Mgr. Tereza Miškechová

Anotace

V originále

As cell therapies emerged, it was quickly realized that pro-regenerative cells directly injected into injured tissue struggled within the inflammatory microenvironment. By using microencapsulation, i.e., encapsulating cells within polymeric biomaterials, they are henceforth protected from the harmful extracellular cues, while still being able to receive oxygen and nutrients and release secreted factors. Previous work showed that stem cells encapsulated within a biologically inert material (agarose) were able to significantly improve the function of the infarcted mouse heart. With the aim of using more bioresponsive microcapsules, we sought to develop an enzymatically degradable, type I collagen-based microcapsule for the intramyocardial delivery of bone marrow-derived mesenchymal stromal cells in a murine model of myocardial infarction.

Citovat

JACQUES, E; K HOSOYAMA; B BINIAM; CE CIMENCI; Veronika SEDLÁKOVÁ; AJ STEEVES; F VARIOLA; DR DAVIS; DJ STEWART; EJ SUURONEN a EI ALARCON. Collagen-Based Microcapsules As Therapeutic Materials for Stem Cell Therapies in Infarcted Myocardium. ACS BIOMATERIALS SCIENCE & ENGINEERING. WASHINGTON: AMER CHEMICAL SOC, 2020, roč. 6, č. 8, s. 4614-4622. ISSN 2373-9878. Dostupné z: https://doi.org/10.1021/acsbiomaterials.0c00245.

@article{1703800,
   author = {Jacques, E and Hosoyama, K and Biniam, B and Cimenci, CE and Sedláková, Veronika and Steeves, AJ and Variola, F and Davis, DR and Stewart, DJ and Suuronen, EJ and Alarcon, EI},
   article_location = {WASHINGTON},
   article_number = {8},
   doi = {https://doi.org/10.1021/acsbiomaterials.0c00245},
   keywords = {cell encapsulation; tissue regeneration; biomimetic matrix; myocardial infarction},
   language = {eng},
   issn = {2373-9878},
   journal = {ACS BIOMATERIALS SCIENCE & ENGINEERING},
   note = {Bez afiliace k MU.},
   title = {Collagen-Based Microcapsules As Therapeutic Materials for Stem Cell Therapies in Infarcted Myocardium},
   volume = {6},
   year = {2020}
}

TY  - JOUR
ID  - 1703800
AU  - Jacques, E - Hosoyama, K - Biniam, B - Cimenci, CE - Sedláková, Veronika - Steeves, AJ - Variola, F - Davis, DR - Stewart, DJ - Suuronen, EJ - Alarcon, EI
PY  - 2020
TI  - Collagen-Based Microcapsules As Therapeutic Materials for Stem Cell Therapies in Infarcted Myocardium
JF  - ACS BIOMATERIALS SCIENCE & ENGINEERING
VL  - 6
IS  - 8
SP  - 4614-4622
EP  - 4614-4622
PB  - AMER CHEMICAL SOC
SN  - 23739878
N1  - Bez afiliace k MU.
KW  - cell encapsulation
KW  - tissue regeneration
KW  - biomimetic matrix
KW  - myocardial infarction
N2  - As cell therapies emerged, it was quickly realized that pro-regenerative cells directly injected into injured tissue struggled within the inflammatory microenvironment. By using microencapsulation, i.e., encapsulating cells within polymeric biomaterials, they are henceforth protected from the harmful extracellular cues, while still being able to receive oxygen and nutrients and release secreted factors. Previous work showed that stem cells encapsulated within a biologically inert material (agarose) were able to significantly improve the function of the infarcted mouse heart. With the aim of using more bioresponsive microcapsules, we sought to develop an enzymatically degradable, type I collagen-based microcapsule for the intramyocardial delivery of bone marrow-derived mesenchymal stromal cells in a murine model of myocardial infarction.
ER  -

JACQUES, E; K HOSOYAMA; B BINIAM; CE CIMENCI; Veronika SEDLÁKOVÁ; AJ STEEVES; F VARIOLA; DR DAVIS; DJ STEWART; EJ SUURONEN a EI ALARCON. Collagen-Based Microcapsules As Therapeutic Materials for Stem Cell Therapies in Infarcted Myocardium. \textit{ACS BIOMATERIALS SCIENCE \&{}amp; ENGINEERING}. WASHINGTON: AMER CHEMICAL SOC, 2020, roč.~6, č.~8, s.~4614-4622. ISSN~2373-9878. Dostupné z: https://doi.org/10.1021/acsbiomaterials.0c00245.

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