Multifunctional Nano and Collagen-Based Therapeutic Materials
for Skin Repair

J 2020

Multifunctional Nano and Collagen-Based Therapeutic Materials for Skin Repair

LAZURKO, C; Z KHATOON; K GOEL; Veronika SEDLÁKOVÁ; CE CIMENCI et al.

Základní údaje

Originální název

Multifunctional Nano and Collagen-Based Therapeutic Materials for Skin Repair

Autoři

LAZURKO, C; Z KHATOON; K GOEL; Veronika SEDLÁKOVÁ; CE CIMENCI; M AHUMADA; L ZHANG; TF MAH; W FRANCO; EJ SUURONEN a EI ALARCON

Vydání

ACS BIOMATERIALS SCIENCE & ENGINEERING, WASHINGTON, AMER CHEMICAL SOC, 2020, 2373-9878

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.749

Označené pro přenos do RIV

DOI

https://doi.org/10.1021/acsbiomaterials.9b01281

UT WoS

000513086900031

Klíčová slova anglicky

wound healing; microskin columns; antiinfective nanomaterials; tissue regeneration

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 1. 2022 10:04, MUDr. Veronika Sedláková, Ph.D.

Anotace

V originále

A novel strategy is needed for treating nonhealing wounds, which is able to simultaneously eradicate pathogenic bacteria and promote tissue regeneration. This would improve patient outcome and reduce the number of lower limb amputations. In this work, we present a multifunctional therapeutic approach able to control bacterial infections, provide a protective barrier to a full-thickness wound, and improve wound healing in a clinically relevant animal model. Our approach uses a nanoengineered antimicrobial nanoparticle for creating a sprayable layer onto the wound bed that prevents bacterial proliferation and also eradicates preformed biofilms. As a protective barrier for the wound, we developed a thermoresponsive collagen-based matrix that has prohealing properties and is able to fill wounds independent of their geometries. Our results indicate that using a combination of the matrix with full-thickness microscopic skin tissue columns synergistically contributed to faster and superior skin regeneration in a nonhealing wound model in diabetic mice.

Citovat

LAZURKO, C; Z KHATOON; K GOEL; Veronika SEDLÁKOVÁ; CE CIMENCI; M AHUMADA; L ZHANG; TF MAH; W FRANCO; EJ SUURONEN a EI ALARCON. Multifunctional Nano and Collagen-Based Therapeutic Materials for Skin Repair. ACS BIOMATERIALS SCIENCE & ENGINEERING. WASHINGTON: AMER CHEMICAL SOC, 2020, roč. 6, č. 2, s. 1124-1134, 21 s. ISSN 2373-9878. Dostupné z: https://doi.org/10.1021/acsbiomaterials.9b01281.

@article{1703801,
   author = {Lazurko, C and Khatoon, Z and Goel, K and Sedláková, Veronika and Cimenci, CE and Ahumada, M and Zhang, L and Mah, TF and Franco, W and Suuronen, EJ and Alarcon, EI},
   article_location = {WASHINGTON},
   article_number = {2},
   doi = {https://doi.org/10.1021/acsbiomaterials.9b01281},
   keywords = {wound healing; microskin columns; antiinfective nanomaterials; tissue regeneration},
   language = {eng},
   issn = {2373-9878},
   journal = {ACS BIOMATERIALS SCIENCE & ENGINEERING},
   title = {Multifunctional Nano and Collagen-Based Therapeutic Materials for Skin Repair},
   volume = {6},
   year = {2020}
}

TY  - JOUR
ID  - 1703801
AU  - Lazurko, C - Khatoon, Z - Goel, K - Sedláková, Veronika - Cimenci, CE - Ahumada, M - Zhang, L - Mah, TF - Franco, W - Suuronen, EJ - Alarcon, EI
PY  - 2020
TI  - Multifunctional Nano and Collagen-Based Therapeutic Materials for Skin Repair
JF  - ACS BIOMATERIALS SCIENCE & ENGINEERING
VL  - 6
IS  - 2
SP  - 1124-1134
EP  - 1124-1134
PB  - AMER CHEMICAL SOC
SN  - 23739878
KW  - wound healing
KW  - microskin columns
KW  - antiinfective nanomaterials
KW  - tissue regeneration
N2  - A novel strategy is needed for treating nonhealing wounds, which is able to simultaneously eradicate pathogenic bacteria and promote tissue regeneration. This would improve patient outcome and reduce the number of lower limb amputations. In this work, we present a multifunctional therapeutic approach able to control bacterial infections, provide a protective barrier to a full-thickness wound, and improve wound healing in a clinically relevant animal model. Our approach uses a nanoengineered antimicrobial nanoparticle for creating a sprayable layer onto the wound bed that prevents bacterial proliferation and also eradicates preformed biofilms. As a protective barrier for the wound, we developed a thermoresponsive collagen-based matrix that has prohealing properties and is able to fill wounds independent of their geometries. Our results indicate that using a combination of the matrix with full-thickness microscopic skin tissue columns synergistically contributed to faster and superior skin regeneration in a nonhealing wound model in diabetic mice.
ER  -

LAZURKO, C; Z KHATOON; K GOEL; Veronika SEDLÁKOVÁ; CE CIMENCI; M AHUMADA; L ZHANG; TF MAH; W FRANCO; EJ SUURONEN a EI ALARCON. Multifunctional Nano and Collagen-Based Therapeutic Materials for Skin Repair. \textit{ACS BIOMATERIALS SCIENCE \&{}amp; ENGINEERING}. WASHINGTON: AMER CHEMICAL SOC, 2020, roč.~6, č.~2, s.~1124-1134, 21 s. ISSN~2373-9878. Dostupné z: https://doi.org/10.1021/acsbiomaterials.9b01281.

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