Anti-MRSA activity of abietane diterpenes from Coleus blumei
Benth.

J 2019

Anti-MRSA activity of abietane diterpenes from Coleus blumei Benth.

JURKANINOVÁ, Sabína; Renata KUBÍNOVÁ; Marcela NEJEZCHLEBOVÁ; Markéta GAZDOVÁ; Zuzana HANAKOVA et al.

Základní údaje

Originální název

Anti-MRSA activity of abietane diterpenes from Coleus blumei Benth.

Autoři

JURKANINOVÁ, Sabína; Renata KUBÍNOVÁ; Marcela NEJEZCHLEBOVÁ; Markéta GAZDOVÁ; Zuzana HANAKOVA a Stefano DALL ACQUA

Vydání

NATURAL PRODUCT RESEARCH, ABINGDON, TAYLOR & FRANCIS LTD, 2019, 1478-6419

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.158

Označené pro přenos do RIV

Klíčová slova anglicky

Coleus blumei; column chromatography; diterpenoids anti-MRSA activity

Změněno: 11. 12. 2020 17:35, doc. PharmDr. Renata Kubínová, Ph.D.

Anotace

V originále

Two heretofore uncharacterised abietane diterpenes, sincoetsin C (1) and 3-hydroxyspirocoleon 7-O-beta-D-glucoside (4), were isolated from a methanolic extract of Coleus blumei Benth. (Lamiaceae), along with the known compounds, scutellarioidone A (2) and spirocoleon 7-O-beta-D-glucoside (3) using chromatographic techniques. Their structures were determined by 1D and 2D nuclear magnetic resonance including HSQC, HMBC, COSY and NOESY experiments, mass spectrometry (HR-MS) and other spectroscopic methods (UV, IR). Their antibacterial activity against the reference strain of methicillin-resistant Staphylococcus aureus subsp. aureus CCM 4750 (MRSA) was evaluated using optical absorption to obtain quantitative information on their growth. All isolated compounds displayed anti-MRSA 4750 activity at the concentration of 512 mu g/mL. Sincoetsin C (1) was the abietane diterpene most active against MRSA 4750, with a minimum inhibitory concentration of 128 mu g/mL.

Citovat

JURKANINOVÁ, Sabína; Renata KUBÍNOVÁ; Marcela NEJEZCHLEBOVÁ; Markéta GAZDOVÁ; Zuzana HANAKOVA a Stefano DALL ACQUA. Anti-MRSA activity of abietane diterpenes from Coleus blumei Benth. NATURAL PRODUCT RESEARCH. ABINGDON: TAYLOR & FRANCIS LTD, 2019, 7 s. ISSN 1478-6419. Dostupné z: https://doi.org/10.1080/14786419.2019.1686371.

@article{1707756,
   author = {Jurkaninová, Sabína and Kubínová, Renata and Nejezchlebová, Marcela and Gazdová, Markéta and Hanakova, Zuzana and Dall Acqua, Stefano},
   article_location = {ABINGDON},
   doi = {https://doi.org/10.1080/14786419.2019.1686371},
   keywords = {Coleus blumei; column chromatography; diterpenoids anti-MRSA activity},
   language = {eng},
   issn = {1478-6419},
   journal = {NATURAL PRODUCT RESEARCH},
   title = {Anti-MRSA activity of abietane diterpenes from Coleus blumei Benth.},
   year = {2019}
}

TY  - JOUR
ID  - 1707756
AU  - Jurkaninová, Sabína - Kubínová, Renata - Nejezchlebová, Marcela - Gazdová, Markéta - Hanakova, Zuzana - Dall Acqua, Stefano
PY  - 2019
TI  - Anti-MRSA activity of abietane diterpenes from Coleus blumei Benth.
JF  - NATURAL PRODUCT RESEARCH
PB  - TAYLOR & FRANCIS LTD
SN  - 14786419
KW  - Coleus blumei
KW  - column chromatography
KW  - diterpenoids anti-MRSA activity
N2  - Two heretofore uncharacterised abietane diterpenes, sincoetsin C (1) and 3-hydroxyspirocoleon 7-O-beta-D-glucoside (4), were isolated from a methanolic extract of Coleus blumei Benth. (Lamiaceae), along with the known compounds, scutellarioidone A (2) and spirocoleon 7-O-beta-D-glucoside (3) using chromatographic techniques. Their structures were determined by 1D and 2D nuclear magnetic resonance including HSQC, HMBC, COSY and NOESY experiments, mass spectrometry (HR-MS) and other spectroscopic methods (UV, IR). Their antibacterial activity against the reference strain of methicillin-resistant Staphylococcus aureus subsp. aureus CCM 4750 (MRSA) was evaluated using optical absorption to obtain quantitative information on their growth. All isolated compounds displayed anti-MRSA 4750 activity at the concentration of 512 mu g/mL. Sincoetsin C (1) was the abietane diterpene most active against MRSA 4750, with a minimum inhibitory concentration of 128 mu g/mL.
ER  -

JURKANINOVÁ, Sabína; Renata KUBÍNOVÁ; Marcela NEJEZCHLEBOVÁ; Markéta GAZDOVÁ; Zuzana HANAKOVA a Stefano DALL ACQUA. Anti-MRSA activity of abietane diterpenes from Coleus blumei Benth. \textit{NATURAL PRODUCT RESEARCH}. ABINGDON: TAYLOR \&{}amp; FRANCIS LTD, 2019, 7 s. ISSN~1478-6419. Dostupné z: https://doi.org/10.1080/14786419.2019.1686371.

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