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@article{1713418, author = {Šrámková, Taťána and Šrámková, K. and Jarkovský, Jiří and Pohanka, Michal and Čermák, Aleš}, article_location = {Westchester}, article_number = {4}, doi = {http://dx.doi.org/10.26717/BJSTR.2020.26.004386}, keywords = {Erectile Dysfunction; Diabetes Type 2; Endothelial Dysfunction; Topical Alprostadil; International Index of Erectile Function; Erectile Hardness Score}, language = {eng}, issn = {2574-1241}, journal = {Biomedical Journal of Scientific & Technical Research}, title = {Examining Endothelial Dysfunction and The Effect of Topical Treatment with Prostaglandin E1 In Diabetics Suffering from Erectile Dysfunction}, url = {https://biomedres.us/fulltexts/BJSTR.MS.ID.004386.php}, volume = {26}, year = {2020} }
TY - JOUR ID - 1713418 AU - Šrámková, Taťána - Šrámková, K. - Jarkovský, Jiří - Pohanka, Michal - Čermák, Aleš PY - 2020 TI - Examining Endothelial Dysfunction and The Effect of Topical Treatment with Prostaglandin E1 In Diabetics Suffering from Erectile Dysfunction JF - Biomedical Journal of Scientific & Technical Research VL - 26 IS - 4 SP - 20160-20166 EP - 20160-20166 PB - Biomedical Research Network SN - 25741241 KW - Erectile Dysfunction KW - Diabetes Type 2 KW - Endothelial Dysfunction KW - Topical Alprostadil KW - International Index of Erectile Function KW - Erectile Hardness Score UR - https://biomedres.us/fulltexts/BJSTR.MS.ID.004386.php L2 - https://biomedres.us/fulltexts/BJSTR.MS.ID.004386.php N2 - Aims: Erectile and endothelial dysfunctions are the most common complications of diabetes. We studied the endothelial function and response to treatment of a topical alprostadil in diabetics with erectile dysfunction. Sample and Methods: 30 patients were enrolled in the non-intervention, postregistration, prospective study with 300 (MU)g alprostadil cream. We examined vascular endothelial function using an ENDO-PAT 2000 device. We used International Index of Erectile Function (IIEF-5), Erectile Hardness Score (EHS), Global Assessment Questionnaire (GAQ) and Sexual Encounter Profile Q 2 and 3 (SEP 2, SEP 3) to assess erectile function. The primary outcome measures were the proportion of patients with an optimal treatment response at baseline and at 6 and 12 weeks after treatment and the evaluation of patients and their partner’s subjective satisfaction. Results: We diagnosed endothelial dysfunction in 15 diabetics. After 12 weeks of treatment with alprostadil 53.3% of the sample, reached normal erectile function. We found a significant increase in IIEF-5 scores with a median of 6 points (range 0–19, p<0.001) after 6 weeks compared to baseline, and of 7 points (range 0–20, p<0.001) after 12 weeks of treatment compared to baseline; a significant increase occurred both after 6 and 12 weeks of treatment (p=0.002). After both 6 and 12 weeks we found a significant increase in erection rigidity, EHS, compared to baseline (p< 0.001, p = 0.014). After 12 weeks of treatment, GAQ, improving erectile function was reached in 76.7% patients. Conclusion: We have demonstrated that topical alprostadil is efficient in diabetic men with erectile-endothelial dysfunction. ER -
ŠRÁMKOVÁ, Taťána, K. ŠRÁMKOVÁ, Jiří JARKOVSKÝ, Michal POHANKA a Aleš ČERMÁK. Examining Endothelial Dysfunction and The Effect of Topical Treatment with Prostaglandin E1 In Diabetics Suffering from Erectile Dysfunction. \textit{Biomedical Journal of Scientific \&{} Technical Research}. Westchester: Biomedical Research Network, 2020, roč.~26, č.~4, s.~20160-20166. ISSN~2574-1241. Dostupné z: https://dx.doi.org/10.26717/BJSTR.2020.26.004386.
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