MR Diffusion Properties of Cervical Spinal Cord as a Predictor
of Progression to Multiple Sclerosis in Patients with
Clinically Isolated Syndrome

J 2021

MR Diffusion Properties of Cervical Spinal Cord as a Predictor of Progression to Multiple Sclerosis in Patients with Clinically Isolated Syndrome

DOSTÁL, Marek, Miloš KEŘKOVSKÝ, Jakub STULÍK, Josef BEDNAŘÍK, Petra PRAKSOVÁ et. al.

Základní údaje

Originální název

MR Diffusion Properties of Cervical Spinal Cord as a Predictor of Progression to Multiple Sclerosis in Patients with Clinically Isolated Syndrome

Autoři

DOSTÁL, Marek (203 Česká republika, domácí), Miloš KEŘKOVSKÝ (203 Česká republika, garant, domácí), Jakub STULÍK (203 Česká republika, domácí), Josef BEDNAŘÍK (203 Česká republika, domácí), Petra PRAKSOVÁ (203 Česká republika, domácí), Monika HULOVÁ (203 Česká republika, domácí), Yvonne BENEŠOVÁ (203 Česká republika, domácí), Eva KORIŤÁKOVÁ (203 Česká republika, domácí), Andrea ŠPRLÁKOVÁ-PUKOVÁ (203 Česká republika, domácí) a Marek MECHL (203 Česká republika, domácí)

Vydání

Journal of Neuroimaging, Hoboken, Wiley-Blackwell, 2021, 1051-2284

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30224 Radiology, nuclear medicine and medical imaging

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.324

Kód RIV

RIV/00216224:14110/21:00120081

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1111/jon.12808

UT WoS

000594060100001

Klíčová slova anglicky

clinically isolated syndrome; diffusion tensor imaging; multiple sclerosis; spine

Štítky

14110216, 14110221, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 2. 2021 14:15, Mgr. Tereza Miškechová

Anotace

V originále

BACKGROUND AND PURPOSE This study's aim was to investigate diffusion properties of the cervical spinal cord in patients with clinically isolated syndrome (CIS) through analysis of diffusion tensor imaging (DTI) data and thereby to assess the capacity of this technique for predicting the progression of CIS to clinically definite multiple sclerosis (CDMS). METHODS The study groups were comprised of 47 patients with CIS (15 of them with progression to CDMS within 2 years of follow-up) and 57 asymptomatic controls. All patients and controls had undergone magnetic resonance imaging (MRI) of the cervical spine including DTI and brain MRI. Methodological approaches included histogram analysis of the cervical cord's diffusion parameters and evaluation of T2 hyperintense lesions of the spinal cord and brain. All parameters were compared between the study groups. Sensitivity and specificity calculations were then performed with a view to predicting conversion to CDMS. RESULTS The patient subgroups defined by progression to CDMS differed significantly in values of fractional anisotropy (FA) kurtosis measured within white matter (WM) and normal-appearing WM (NAWM). The same parameters also differed significantly when patients with progression to CDMS were compared to healthy controls. Receiver operating characteristic (ROC) analysis revealed sensitivity and specificity of FA kurtosis of WM and NAWM of 93% and 72%, respectively, in terms of predicting CIS to CDMS progression. CONCLUSION This study presents evidence that histogram analysis of diffusion parameters of the cervical spinal cord in patients with CIS may be helpful in predicting conversion to CDMS.

Návaznosti

MUNI/A/1488/2019, interní kód MU

Název: Význam radiologických intervencí a pokročilých zobrazovacích metod v diagnostice a léčbě onkologických pacientů

Investor: Masarykova univerzita, Význam radiologických intervencí a pokročilých zobrazovacích metod v diagnostice a léčbě onkologických pacientů, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

NV15-32133A, projekt VaV

Název: Predikce konverze klinicky izolovaného syndromu do roztroušené sklerózy pomocí pokročilých technik zobrazení magnetickou rezonancí

Citovat

DOSTÁL, Marek, Miloš KEŘKOVSKÝ, Jakub STULÍK, Josef BEDNAŘÍK, Petra PRAKSOVÁ, Monika HULOVÁ, Yvonne BENEŠOVÁ, Eva KORIŤÁKOVÁ, Andrea ŠPRLÁKOVÁ-PUKOVÁ a Marek MECHL. MR Diffusion Properties of Cervical Spinal Cord as a Predictor of Progression to Multiple Sclerosis in Patients with Clinically Isolated Syndrome. Journal of Neuroimaging. Hoboken: Wiley-Blackwell, 2021, roč. 31, č. 1, s. 108-114. ISSN 1051-2284. Dostupné z: https://dx.doi.org/10.1111/jon.12808.

@article{1713456,
   author = {Dostál, Marek and Keřkovský, Miloš and Stulík, Jakub and Bednařík, Josef and Praksová, Petra and Hulová, Monika and Benešová, Yvonne and Koriťáková, Eva and ŠprlákováandPuková, Andrea and Mechl, Marek},
   article_location = {Hoboken},
   article_number = {1},
   doi = {http://dx.doi.org/10.1111/jon.12808},
   keywords = {clinically isolated syndrome; diffusion tensor imaging; multiple sclerosis; spine},
   language = {eng},
   issn = {1051-2284},
   journal = {Journal of Neuroimaging},
   title = {MR Diffusion Properties of Cervical Spinal Cord as a Predictor of Progression to Multiple Sclerosis in Patients with Clinically Isolated Syndrome},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/jon.12808},
   volume = {31},
   year = {2021}
}

TY  - JOUR
ID  - 1713456
AU  - Dostál, Marek - Keřkovský, Miloš - Stulík, Jakub - Bednařík, Josef - Praksová, Petra - Hulová, Monika - Benešová, Yvonne - Koriťáková, Eva - Šprláková-Puková, Andrea - Mechl, Marek
PY  - 2021
TI  - MR Diffusion Properties of Cervical Spinal Cord as a Predictor of Progression to Multiple Sclerosis in Patients with Clinically Isolated Syndrome
JF  - Journal of Neuroimaging
VL  - 31
IS  - 1
SP  - 108-114
EP  - 108-114
PB  - Wiley-Blackwell
SN  - 10512284
KW  - clinically isolated syndrome
KW  - diffusion tensor imaging
KW  - multiple sclerosis
KW  - spine
UR  - https://onlinelibrary.wiley.com/doi/10.1111/jon.12808
L2  - https://onlinelibrary.wiley.com/doi/10.1111/jon.12808
N2  - BACKGROUND AND PURPOSE This study's aim was to investigate diffusion properties of the cervical spinal cord in patients with clinically isolated syndrome (CIS) through analysis of diffusion tensor imaging (DTI) data and thereby to assess the capacity of this technique for predicting the progression of CIS to clinically definite multiple sclerosis (CDMS). METHODS The study groups were comprised of 47 patients with CIS (15 of them with progression to CDMS within 2 years of follow-up) and 57 asymptomatic controls. All patients and controls had undergone magnetic resonance imaging (MRI) of the cervical spine including DTI and brain MRI. Methodological approaches included histogram analysis of the cervical cord's diffusion parameters and evaluation of T2 hyperintense lesions of the spinal cord and brain. All parameters were compared between the study groups. Sensitivity and specificity calculations were then performed with a view to predicting conversion to CDMS. RESULTS The patient subgroups defined by progression to CDMS differed significantly in values of fractional anisotropy (FA) kurtosis measured within white matter (WM) and normal-appearing WM (NAWM). The same parameters also differed significantly when patients with progression to CDMS were compared to healthy controls. Receiver operating characteristic (ROC) analysis revealed sensitivity and specificity of FA kurtosis of WM and NAWM of 93% and 72%, respectively, in terms of predicting CIS to CDMS progression. CONCLUSION This study presents evidence that histogram analysis of diffusion parameters of the cervical spinal cord in patients with CIS may be helpful in predicting conversion to CDMS.
ER  -

DOSTÁL, Marek, Miloš KEŘKOVSKÝ, Jakub STULÍK, Josef BEDNAŘÍK, Petra PRAKSOVÁ, Monika HULOVÁ, Yvonne BENEŠOVÁ, Eva KORIŤÁKOVÁ, Andrea ŠPRLÁKOVÁ-PUKOVÁ a Marek MECHL. MR Diffusion Properties of Cervical Spinal Cord as a Predictor of Progression to Multiple Sclerosis in Patients with Clinically Isolated Syndrome. \textit{Journal of Neuroimaging}. Hoboken: Wiley-Blackwell, 2021, roč.~31, č.~1, s.~108-114. ISSN~1051-2284. Dostupné z: https://dx.doi.org/10.1111/jon.12808.

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