| KHAZNEH, E., P. HRIBOVA, J. HOSEK, Pavel SUCHÝ, Peter KOLLÁR, G. PRAZANOVA, Jan MUSELÍK, Z. HANAKOVA, Jiří VÁCLAVÍK, M. MILEK, J. LEGATH a Karel ŠMEJKAL. The Chemical Composition of Achillea wilhelmsii C. Koch and Its Desirable Effects on Hyperglycemia, Inflammatory Mediators and Hypercholesterolemia as Risk Factors for Cardiometabolic Disease. Molecules. BASEL: Mayer und Muller, 2016, roč. 21, č. 4, 18 s. ISSN 1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules21040404. |
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@article{1726809,
author = {Khazneh, E. and Hribova, P. and Hosek, J. and Suchý, Pavel and Kollár, Peter and Prazanova, G. and Muselík, Jan and Hanakova, Z. and Václavík, Jiří and Milek, M. and Legath, J. and Šmejkal, Karel},
article_location = {BASEL},
article_number = {4},
doi = {http://dx.doi.org/10.3390/molecules21040404},
keywords = {Achillea wilhelmsii; anti-hypercholesterolemic; cardiometabolic disease; docking; flavonoids; 3-hydroxy-3-methylglutaryl-CoA reductase; hypoglycemic; inflammation},
language = {eng},
issn = {1420-3049},
journal = {Molecules},
title = {The Chemical Composition of Achillea wilhelmsii C. Koch and Its Desirable Effects on Hyperglycemia, Inflammatory Mediators and Hypercholesterolemia as Risk Factors for Cardiometabolic Disease},
volume = {21},
year = {2016}
}
TY - JOUR
ID - 1726809
AU - Khazneh, E. - Hribova, P. - Hosek, J. - Suchý, Pavel - Kollár, Peter - Prazanova, G. - Muselík, Jan - Hanakova, Z. - Václavík, Jiří - Milek, M. - Legath, J. - Šmejkal, Karel
PY - 2016
TI - The Chemical Composition of Achillea wilhelmsii C. Koch and Its Desirable Effects on Hyperglycemia, Inflammatory Mediators and Hypercholesterolemia as Risk Factors for Cardiometabolic Disease
JF - Molecules
VL - 21
IS - 4
PB - Mayer und Muller
SN - 14203049
KW - Achillea wilhelmsii
KW - anti-hypercholesterolemic
KW - cardiometabolic disease
KW - docking
KW - flavonoids
KW - 3-hydroxy-3-methylglutaryl-CoA reductase
KW - hypoglycemic
KW - inflammation
N2 - This study was done to identify the content compounds of Achillea wilhelmsii (A. wilhelmsii) and to evaluate its hypoglycemic and anti-hypercholesterolemic activity and effect on inflammatory mediators. The extracts and fractions of A. wilhelmsii were thoroughly analyzed using high performance liquid chromatography (HPLC), and the total content of phenols and flavonoids was determined. The hypoglycemic activity was evaluated in vivo using alloxan-induced diabetic mice. The effect upon inflammatory mediators was evaluated in vitro using the human monocytic leukemia cell line (THP-1). The anti-hypercholesterolemic activity was evaluated in vitro using the 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase assay kit. The water extract (WE)-treated group showed the highest reduction in the fasting blood glucose levels (FBGL). The chloroform fraction (CF) and ethyl acetate fraction (EAF) both showed a significant ability to reduce the secretion of tumor necrosis factor alpha (TNF-alpha). The EAF, however, also attenuated the levels of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). The CF showed the most significant 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibition activity. The five main compounds in the CF were isolated and identified. Out of the five compounds in the CF, 1 beta,10 beta-epoxydesacetoxymatricarin (CP1) and leucodin (CP2) showed the highest anti-hypercholesterolemic potential. A molecular docking study provided corresponding results.
ER -
KHAZNEH, E., P. HRIBOVA, J. HOSEK, Pavel SUCHÝ, Peter KOLLÁR, G. PRAZANOVA, Jan MUSELÍK, Z. HANAKOVA, Jiří VÁCLAVÍK, M. MILEK, J. LEGATH a Karel ŠMEJKAL. The Chemical Composition of Achillea wilhelmsii C. Koch and Its Desirable Effects on Hyperglycemia, Inflammatory Mediators and Hypercholesterolemia as Risk Factors for Cardiometabolic Disease. \textit{Molecules}. BASEL: Mayer und Muller, 2016, roč.~21, č.~4, 18 s. ISSN~1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules21040404.
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