Flavonoids as Potent Scavengers of Hydroxyl Radicals

J 2016

Flavonoids as Potent Scavengers of Hydroxyl Radicals

TREML, Jakub a Karel ŠMEJKAL

Základní údaje

Originální název

Flavonoids as Potent Scavengers of Hydroxyl Radicals

Autoři

TREML, Jakub a Karel ŠMEJKAL

Vydání

COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY, HOBOKEN, WILEY-BLACKWELL, 2016, 1541-4337

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 5.974

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.1111/1541-4337.12204

UT WoS

000379040900004

Klíčová slova anglicky

Fenton reaction; flavonoids; hydroxyl radical; scavenging; structure-activity relationship

Změněno: 25. 1. 2021 17:29, Mgr. Michal Petr

Anotace

V originále

Oxidative stress is a fundamental principle in the pathophysiology of many diseases. It occurs when the production of reactive oxygen species exceeds the capacity of the cell defense system. The hydroxyl radical is a reactive oxygen species that is commonly formed in vivo and can cause serious damage to biomolecules, such as lipids, proteins, and nucleic acids. It plays a role in inflammation-related diseases, like chronic inflammation, neurodegeneration, and cancer. To overcome excessive oxidative stress and thus to prevent or stop the progression of diseases connected to it, scientists try to combat oxidative stress and to find antioxidant molecules, including those that scavenge hydroxyl radical or diminish its production in inflamed tissues. This article reviews various methods of hydroxyl radical production and scavenging. Further, flavonoids, as natural plant antioxidants and essential component of the human diet, are reviewed as compounds interacting with the production of hydroxyl radicals. The relationship between hydroxyl radical scavenging and the structure of the flavonoids is discussed. The structural elements of the flavonoid molecule most important for hydroxyl radical scavenging are hydroxylation of ring B and a C2-C3 double bond connected with a C-3 hydroxyl group and a C-4 carbonyl group. Hydroxylation of ring A also enhances the activity, as does the presence of gallate and galactouronate moieties as substituents on the flavonoid skeleton.

Citovat

TREML, Jakub a Karel ŠMEJKAL. Flavonoids as Potent Scavengers of Hydroxyl Radicals. COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY. HOBOKEN: WILEY-BLACKWELL, 2016, roč. 15, č. 4, s. 720-738. ISSN 1541-4337. Dostupné z: https://dx.doi.org/10.1111/1541-4337.12204.

@article{1726822,
   author = {Treml, Jakub and Šmejkal, Karel},
   article_location = {HOBOKEN},
   article_number = {4},
   doi = {http://dx.doi.org/10.1111/1541-4337.12204},
   keywords = {Fenton reaction; flavonoids; hydroxyl radical; scavenging; structure-activity relationship},
   language = {eng},
   issn = {1541-4337},
   journal = {COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY},
   title = {Flavonoids as Potent Scavengers of Hydroxyl Radicals},
   volume = {15},
   year = {2016}
}

TY  - JOUR
ID  - 1726822
AU  - Treml, Jakub - Šmejkal, Karel
PY  - 2016
TI  - Flavonoids as Potent Scavengers of Hydroxyl Radicals
JF  - COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
VL  - 15
IS  - 4
SP  - 720-738
EP  - 720-738
PB  - WILEY-BLACKWELL
SN  - 15414337
KW  - Fenton reaction
KW  - flavonoids
KW  - hydroxyl radical
KW  - scavenging
KW  - structure-activity relationship
N2  - Oxidative stress is a fundamental principle in the pathophysiology of many diseases. It occurs when the production of reactive oxygen species exceeds the capacity of the cell defense system. The hydroxyl radical is a reactive oxygen species that is commonly formed in vivo and can cause serious damage to biomolecules, such as lipids, proteins, and nucleic acids. It plays a role in inflammation-related diseases, like chronic inflammation, neurodegeneration, and cancer. To overcome excessive oxidative stress and thus to prevent or stop the progression of diseases connected to it, scientists try to combat oxidative stress and to find antioxidant molecules, including those that scavenge hydroxyl radical or diminish its production in inflamed tissues. This article reviews various methods of hydroxyl radical production and scavenging. Further, flavonoids, as natural plant antioxidants and essential component of the human diet, are reviewed as compounds interacting with the production of hydroxyl radicals. The relationship between hydroxyl radical scavenging and the structure of the flavonoids is discussed. The structural elements of the flavonoid molecule most important for hydroxyl radical scavenging are hydroxylation of ring B and a C2-C3 double bond connected with a C-3 hydroxyl group and a C-4 carbonyl group. Hydroxylation of ring A also enhances the activity, as does the presence of gallate and galactouronate moieties as substituents on the flavonoid skeleton.
ER  -

TREML, Jakub a Karel ŠMEJKAL. Flavonoids as Potent Scavengers of Hydroxyl Radicals. \textit{COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY}. HOBOKEN: WILEY-BLACKWELL, 2016, roč.~15, č.~4, s.~720-738. ISSN~1541-4337. Dostupné z: https://dx.doi.org/10.1111/1541-4337.12204.

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