Další formáty:
BibTeX
LaTeX
RIS
@article{1726889,
author = {Acikara, O.B. and Hosek, J. and Babula, Petr and Cvacka, J. and Budesinsky, M. and Dracinsky, M. and Iscan, G.S. and Kadlecova, D. and Ballova, L. and Šmejkal, Karel},
article_location = {BASEL},
article_number = {1},
doi = {http://dx.doi.org/10.3390/molecules21010043},
keywords = {anti-inflammatory activity; IL-1; NF-B; Scorzonera; phenolic; TNF-; triterpen},
language = {eng},
issn = {1420-3049},
journal = {Molecules},
title = {Turkish Scorzonera Species Extracts Attenuate Cytokine Secretion via Inhibition of NF-kappa B Activation, Showing Anti-Inflammatory Effect in Vitro},
volume = {21},
year = {2016}
}
TY - JOUR
ID - 1726889
AU - Acikara, O.B. - Hosek, J. - Babula, Petr - Cvacka, J. - Budesinsky, M. - Dracinsky, M. - Iscan, G.S. - Kadlecova, D. - Ballova, L. - Šmejkal, Karel
PY - 2016
TI - Turkish Scorzonera Species Extracts Attenuate Cytokine Secretion via Inhibition of NF-kappa B Activation, Showing Anti-Inflammatory Effect in Vitro
JF - Molecules
VL - 21
IS - 1
PB - Mayer und Muller
SN - 14203049
KW - anti-inflammatory activity
KW - IL-1
KW - NF-B
KW - Scorzonera
KW - phenolic
KW - TNF-
KW - triterpen
N2 - Scorzonera species are used in different folk medicines to combat many diseases, including the illnesses connected with inflammation. Previous experiments showed anti-inflammatory activity of Scorzonera extracts in vivo. S. latifolia, S. cana var. jacquiniana, S. tomentosa, S. mollis ssp. szowitsii, S. eriophora, S. incisa, S. cinerea, and S. parviflora extracts were, therefore, evaluated for their inhibitory activities of TNF- and IL-1 production, and NF-B nuclear translocation in THP-1 macrophages. The HPLC analysis was carried out to elucidate and to compare the composition of these extracts. Major compounds of the tested extracts have been isolated using different chromatographic techniques and further tested for their inhibitory activities on TNF- and IL-1 production. Several extracts showed promising anti-inflammatory activity in these in vitro tests. Results of HPLC analysis revealed chlorogenic acid as a compound present in all tested extracts. Hyperoside, quercetin-3-O--d-glucoside and rutin were also present in varying amount in some Scorzonera species analyzed. Furthermore, eight phenolics which were identified as quercetin-3-O--d-glucoside (1), hyperoside (2), hydrangenol-8-O-glucoside (3), swertisin (4), 7-methylisoorientin (5), 4,5-O-dicaffeoyl-quinic acid (6), 3,5-di-O-caffeoyl-quinic acid (7), and chlorogenic acid (8) have been isolated as major phenolic compounds of the tested extracts and, together with eight terpenoids (9-16) previously obtained from different Scorzonera species, have been tested for the inhibition of TNF- production, unfortunately with no activity comparable with standard.
ER -
ACIKARA, O.B., J. HOSEK, Petr BABULA, J. CVACKA, M. BUDESINSKY, M. DRACINSKY, G.S. ISCAN, D. KADLECOVA, L. BALLOVA a Karel ŠMEJKAL. Turkish Scorzonera Species Extracts Attenuate Cytokine Secretion via Inhibition of NF-kappa B Activation, Showing Anti-Inflammatory Effect in Vitro. \textit{Molecules}. BASEL: Mayer und Muller, 2016, roč.~21, č.~1, 14 s. ISSN~1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules21010043.
|
