Parallel in vitro and in silico investigations into
anti-inflammatory effects of non-prenylated stilbenoids

J 2019

Parallel in vitro and in silico investigations into anti-inflammatory effects of non-prenylated stilbenoids

LELÁKOVÁ, Veronika; Karel ŠMEJKAL; K. JAKUBCZYK; O. VESELY; P. LANDA et al.

Základní údaje

Originální název

Parallel in vitro and in silico investigations into anti-inflammatory effects of non-prenylated stilbenoids

Autoři

LELÁKOVÁ, Veronika ; Karel ŠMEJKAL; K. JAKUBCZYK; O. VESELY; P. LANDA; Jiří VÁCLAVÍK; Pavel BOBÁĽ; Hana PÍŽOVÁ; V. TEMML; T. STEINACHER; D. SCHUSTER; S. GRANICA; Z. HANAKOVA a J. HOSEK

Vydání

Food Chemistry, Oxford, UK, Elsevier Science, 2019, 0308-8146

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 6.306

Označené pro přenos do RIV

Organizační jednotka

Farmaceutická fakulta

Klíčová slova anglicky

Anti-inflammatory; Cyclooxygenase; Molecular docking simulations; Lipoxygenase; Macrophages; NF-kappa B; Stilbenes

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 2. 2021 14:02, PharmDr. Jitka Michlíčková

Anotace

V originále

Stilbenoids represent a large group of bioactive compounds, which occur in food and medicinal plants. Twenty-five stilbenoids were screened in vitro for their ability to inhibit COX-1, COX-2 and 5-LOX. Piceatannol and pinostilbene showed activity comparable to the zileuton and ibuprofen, respectively. The anti-inflammatory potential of stilbenoids was further evaluated using THP-1 human monocytic leukemia cell line. Tests of the cytotoxicity on the THP-1 and HCT116 cell lines showed very low toxic effects. The tested stilbenoids were evaluated for their ability to attenuate the LPS-stimulated activation of NF-kappa B/AP-1. Most of the tested substances reduced the activity of NF-kappa B/AP-1 and later attenuated the expression of TNF-alpha. The effects of selected stilbenoids were further investigated on inflammatory signaling pathways. Non-prenylated stilbenoids regulated attenuation of NF-kappa B/AP-1 activity upstream by inhibiting the phosphorylation of MAPKs. A docking study used to in silico analyze the tested compounds confirmed their interaction with NF-kappa B, COX-2 and 5-LOX.

Citovat

LELÁKOVÁ, Veronika; Karel ŠMEJKAL; K. JAKUBCZYK; O. VESELY; P. LANDA; Jiří VÁCLAVÍK; Pavel BOBÁĽ; Hana PÍŽOVÁ; V. TEMML; T. STEINACHER; D. SCHUSTER; S. GRANICA; Z. HANAKOVA a J. HOSEK. Parallel in vitro and in silico investigations into anti-inflammatory effects of non-prenylated stilbenoids. Food Chemistry. Oxford, UK: Elsevier Science, 2019, roč. 285, s. 431-440. ISSN 0308-8146. Dostupné z: https://doi.org/10.1016/j.foodchem.2019.01.128.

@article{1726916,
   author = {Leláková, Veronika and Šmejkal, Karel and Jakubczyk, K. and Vesely, O. and Landa, P. and Václavík, Jiří and Bobáľ, Pavel and Pížová, Hana and Temml, V. and Steinacher, T. and Schuster, D. and Granica, S. and Hanakova, Z. and Hosek, J.},
   article_location = {Oxford, UK},
   doi = {https://doi.org/10.1016/j.foodchem.2019.01.128},
   keywords = {Anti-inflammatory; Cyclooxygenase; Molecular docking simulations; Lipoxygenase; Macrophages; NF-kappa B; Stilbenes},
   language = {eng},
   issn = {0308-8146},
   journal = {Food Chemistry},
   title = {Parallel in vitro and in silico investigations into anti-inflammatory effects of non-prenylated stilbenoids},
   volume = {285},
   year = {2019}
}

TY  - JOUR
ID  - 1726916
AU  - Leláková, Veronika - Šmejkal, Karel - Jakubczyk, K. - Vesely, O. - Landa, P. - Václavík, Jiří - Bobáľ, Pavel - Pížová, Hana - Temml, V. - Steinacher, T. - Schuster, D. - Granica, S. - Hanakova, Z. - Hosek, J.
PY  - 2019
TI  - Parallel in vitro and in silico investigations into anti-inflammatory effects of non-prenylated stilbenoids
JF  - Food Chemistry
VL  - 285
SP  - 431-440
EP  - 431-440
PB  - Elsevier Science
SN  - 03088146
KW  - Anti-inflammatory
KW  - Cyclooxygenase
KW  - Molecular docking simulations
KW  - Lipoxygenase
KW  - Macrophages
KW  - NF-kappa B
KW  - Stilbenes
N2  - Stilbenoids represent a large group of bioactive compounds, which occur in food and medicinal plants. Twenty-five stilbenoids were screened in vitro for their ability to inhibit COX-1, COX-2 and 5-LOX. Piceatannol and pinostilbene showed activity comparable to the zileuton and ibuprofen, respectively. The anti-inflammatory potential of stilbenoids was further evaluated using THP-1 human monocytic leukemia cell line. Tests of the cytotoxicity on the THP-1 and HCT116 cell lines showed very low toxic effects. The tested stilbenoids were evaluated for their ability to attenuate the LPS-stimulated activation of NF-kappa B/AP-1. Most of the tested substances reduced the activity of NF-kappa B/AP-1 and later attenuated the expression of TNF-alpha. The effects of selected stilbenoids were further investigated on inflammatory signaling pathways. Non-prenylated stilbenoids regulated attenuation of NF-kappa B/AP-1 activity upstream by inhibiting the phosphorylation of MAPKs. A docking study used to in silico analyze the tested compounds confirmed their interaction with NF-kappa B, COX-2 and 5-LOX.
ER  -

LELÁKOVÁ, Veronika; Karel ŠMEJKAL; K. JAKUBCZYK; O. VESELY; P. LANDA; Jiří VÁCLAVÍK; Pavel BOBÁĽ; Hana PÍŽOVÁ; V. TEMML; T. STEINACHER; D. SCHUSTER; S. GRANICA; Z. HANAKOVA a J. HOSEK. Parallel in vitro and in silico investigations into anti-inflammatory effects of non-prenylated stilbenoids. \textit{Food Chemistry}. Oxford, UK: Elsevier Science, 2019, roč.~285, s.~431-440. ISSN~0308-8146. Dostupné z: https://doi.org/10.1016/j.foodchem.2019.01.128.

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