Antioxidant Activity of Selected Stilbenoid Derivatives in a
Cellular Model System

J 2019

Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System

TREML, Jakub; Veronika LELÁKOVÁ; Karel ŠMEJKAL; T PAULICKOVA; S LABUDA et al.

Základní údaje

Originální název

Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System

Autoři

TREML, Jakub; Veronika LELÁKOVÁ ; Karel ŠMEJKAL; T PAULICKOVA; S LABUDA; S GRANICA; J HAVLIK; Dagmar JANKOVSKÁ ; Tereza PADRTOVÁ a J HOSEK

Vydání

Biomolecules, BASEL, MDPI, 2019, 0066-605X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Organizační jednotka

Farmaceutická fakulta

Klíčová slova anglicky

stilbenoid; antioxidant; pro-oxidant; pyocyanin; Nrf2; macrophages

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 2. 2021 13:44, PharmDr. Jitka Michlíčková

Anotace

V originále

The stilbenoids, a group of naturally occurring phenolic compounds, are found in a variety of plants, including some berries that are used as food or for medicinal purposes. They are known to be beneficial for human health as anti-inflammatory, chemopreventive, and antioxidative agents. We have investigated a group of 19 stilbenoid substances in vitro using a cellular model of THP-1 macrophage-like cells and pyocyanin-induced oxidative stress to evaluate their antioxidant or pro-oxidant properties. Then we have determined any effects that they might have on the expression of the enzymes catalase, glutathione peroxidase, and heme oxygenase-1, and their effects on the activation of Nrf2. The experimental results showed that these stilbenoids could affect the formation of reactive oxygen species in a cellular model, producing either an antioxidative or pro-oxidative effect, depending on the structure pinostilbene (2) worked as a pro-oxidant and also decreased expression of catalase in the cell culture. Piceatannol (4) had shown reactive oxygen species (ROS) scavenging activity, whereas isorhapontigenin (18) had a mild direct antioxidant effect and activated Nrf2-antioxidant response element (ARE) system and elevated expression of Nrf2 and catalase. Their effects shown on cells in vitro warrant their further study in vivo.

Citovat

TREML, Jakub; Veronika LELÁKOVÁ; Karel ŠMEJKAL; T PAULICKOVA; S LABUDA; S GRANICA; J HAVLIK; Dagmar JANKOVSKÁ; Tereza PADRTOVÁ a J HOSEK. Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System. Biomolecules. BASEL: MDPI, 2019, roč. 9, č. 9, 16 s. ISSN 0066-605X. Dostupné z: https://doi.org/10.3390/biom9090468.

@article{1726960,
   author = {Treml, Jakub and Leláková, Veronika and Šmejkal, Karel and Paulickova, T and Labuda, S and Granica, S and Havlik, J and Jankovská, Dagmar and Padrtová, Tereza and Hosek, J},
   article_location = {BASEL},
   article_number = {9},
   doi = {https://doi.org/10.3390/biom9090468},
   keywords = {stilbenoid; antioxidant; pro-oxidant; pyocyanin; Nrf2; macrophages},
   language = {eng},
   issn = {0066-605X},
   journal = {Biomolecules},
   title = {Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System},
   volume = {9},
   year = {2019}
}

TY  - JOUR
ID  - 1726960
AU  - Treml, Jakub - Leláková, Veronika - Šmejkal, Karel - Paulickova, T - Labuda, S - Granica, S - Havlik, J - Jankovská, Dagmar - Padrtová, Tereza - Hosek, J
PY  - 2019
TI  - Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System
JF  - Biomolecules
VL  - 9
IS  - 9
PB  - MDPI
SN  - 0066605X
KW  - stilbenoid
KW  - antioxidant
KW  - pro-oxidant
KW  - pyocyanin
KW  - Nrf2
KW  - macrophages
N2  - The stilbenoids, a group of naturally occurring phenolic compounds, are found in a variety of plants, including some berries that are used as food or for medicinal purposes. They are known to be beneficial for human health as anti-inflammatory, chemopreventive, and antioxidative agents. We have investigated a group of 19 stilbenoid substances in vitro using a cellular model of THP-1 macrophage-like cells and pyocyanin-induced oxidative stress to evaluate their antioxidant or pro-oxidant properties. Then we have determined any effects that they might have on the expression of the enzymes catalase, glutathione peroxidase, and heme oxygenase-1, and their effects on the activation of Nrf2. The experimental results showed that these stilbenoids could affect the formation of reactive oxygen species in a cellular model, producing either an antioxidative or pro-oxidative effect, depending on the structure pinostilbene (2) worked as a pro-oxidant and also decreased expression of catalase in the cell culture. Piceatannol (4) had shown reactive oxygen species (ROS) scavenging activity, whereas isorhapontigenin (18) had a mild direct antioxidant effect and activated Nrf2-antioxidant response element (ARE) system and elevated expression of Nrf2 and catalase. Their effects shown on cells in vitro warrant their further study in vivo.
ER  -

TREML, Jakub; Veronika LELÁKOVÁ; Karel ŠMEJKAL; T PAULICKOVA; S LABUDA; S GRANICA; J HAVLIK; Dagmar JANKOVSKÁ; Tereza PADRTOVÁ a J HOSEK. Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System. \textit{Biomolecules}. BASEL: MDPI, 2019, roč.~9, č.~9, 16 s. ISSN~0066-605X. Dostupné z: https://doi.org/10.3390/biom9090468.

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