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@article{1726978, author = {Vítovec, Jiří and Špinar, Jindřich and Špinarová, Lenka}, article_number = {1}, keywords = {Canagliflozin; Cardiovascular and renal safety; Programme CANVAS; Type 2 diabetes mellitus}, language = {cze}, issn = {1212-4540}, journal = {Kardiologická revue}, title = {CANVAS – Canagliflozin a kardiovaskulární a renální vliv u diabetes mellitus 2. Typu}, url = {https://www.kardiologickarevue.cz/casopisy/kardiologicka-revue/2019-1-12/canvas-canagliflozin-a-kardiovaskularni-a-renalni-vliv-u-diabetes-mellitus-2-typu-109103}, volume = {21}, year = {2019} }
TY - JOUR ID - 1726978 AU - Vítovec, Jiří - Špinar, Jindřich - Špinarová, Lenka PY - 2019 TI - CANVAS – Canagliflozin a kardiovaskulární a renální vliv u diabetes mellitus 2. Typu JF - Kardiologická revue VL - 21 IS - 1 SP - 15 - 18 EP - 15 - 18 PB - Ambit Media a.s. SN - 12124540 KW - Canagliflozin KW - Cardiovascular and renal safety KW - Programme CANVAS KW - Type 2 diabetes mellitus UR - https://www.kardiologickarevue.cz/casopisy/kardiologicka-revue/2019-1-12/canvas-canagliflozin-a-kardiovaskularni-a-renalni-vliv-u-diabetes-mellitus-2-typu-109103 N2 - Canagliflozin is a sodium-glucose cotransporter 2 inhibitor that reduces glycaemia as well as blood pressure, body weight, and albuminuria in people with diabetes. The CANVAS Programme integrated data from two trials involving a total of 10,142 participants with type 2 diabetes and high cardiovascular risk. Participants in each trial were randomly assigned to receive canagliflozin or placebo and were followed for a mean of 188.2 weeks. The primary outcome was a composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. Conclusions: In two trials involving patients with type 2 diabetes and an elevated risk of cardiovascular disease, patients treated with canagliflozin had a significantly lower risk of cardiovascular events than those who received placebo. A boundary higher risk of amputation, primarily at the level of the toe or metatarsus was observed in the study. These complications, however, were not proved in subsequent observational databases. © 2019, Ambit Media a.s.. All rights reserved. ER -
VÍTOVEC, Jiří, Jindřich ŠPINAR a Lenka ŠPINAROVÁ. CANVAS – Canagliflozin~a~kardiovaskulární~a~renální vliv u~diabetes~mellitus~2. Typu. \textit{Kardiologická revue}. Ambit Media a.s., 2019, roč.~21, č.~1, s.~15 - 18. ISSN~1212-4540.
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