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@article{1730416, author = {Filip, Pavel and Vojtíšek, Lubomír and Baláž, Marek and Mangia, Silvia and Michaeli, Shalom and Šumec, Rastislav and Bareš, Martin}, article_location = {Oxford}, article_number = {December 2020}, doi = {http://dx.doi.org/10.1016/j.parkreldis.2020.10.048}, keywords = {Tremor; Parkinson's disease; Essential tremor; Adiabatic T1 rho and T2 rho mapping; T1 and T2 mapping}, language = {eng}, issn = {1353-8020}, journal = {Parkinsonism and Related Disorders}, title = {Differential diagnosis of tremor syndromes using MRI relaxometry}, url = {https://www.sciencedirect.com/science/article/pii/S135380202030849X}, volume = {81}, year = {2020} }
TY - JOUR ID - 1730416 AU - Filip, Pavel - Vojtíšek, Lubomír - Baláž, Marek - Mangia, Silvia - Michaeli, Shalom - Šumec, Rastislav - Bareš, Martin PY - 2020 TI - Differential diagnosis of tremor syndromes using MRI relaxometry JF - Parkinsonism and Related Disorders VL - 81 IS - December 2020 SP - 190-193 EP - 190-193 PB - Elsevier SN - 13538020 KW - Tremor KW - Parkinson's disease KW - Essential tremor KW - Adiabatic T1 rho and T2 rho mapping KW - T1 and T2 mapping UR - https://www.sciencedirect.com/science/article/pii/S135380202030849X L2 - https://www.sciencedirect.com/science/article/pii/S135380202030849X N2 - Differential diagnosis of the most common tremor syndromes - essential tremor (ET) and Parkinson's disease (PD) is burdened with high error rate. However, diagnostic MRI biomarkers applicable in this clinically highly relevant scenario remain an unfulfilled objective. The presented study was designed in search for possible candidate MRI protocols relevant for differential diagnostic process in tremor syndromes.10 non-advanced tremor-dominant PD patients meeting diagnostic criteria for clinically established PD, 12 isolated ET patients and 16 healthy controls were enrolled into this study. The study focused on relaxation MRI protocols - T1, T2, adiabatic T1 rho and adiabatic T2 rho due to their relatively low post-processing requirements enabling implementation into routine clinical practice. Compared to ET, PD patients had significantly longer T2 relaxation times in striata with dominant findings in the putamen contralateral to the clinically more affected body side. This difference was driven by alterations in the PD group as confirmed in the complementary comparison with healthy controls. According to the receiver operating characteristic analysis, this region provided a reasonable sensitivity of 0.91 and specificity of 0.89 in the differential diagnosis of PD and ET. In PD patients, we further found prolonged T1 rho in the substantia nigra compared to ET and healthy controls, and shorter T2 and T2 rho in the cerebellum compared to healthy controls. T2 relaxation time in the putamen contralateral to the clinically more affected body side is a plausible candidate diagnostic marker for the differentiation of PD and ET. ER -
FILIP, Pavel, Lubomír VOJTÍŠEK, Marek BALÁŽ, Silvia MANGIA, Shalom MICHAELI, Rastislav ŠUMEC a Martin BAREŠ. Differential diagnosis of tremor syndromes using MRI relaxometry. \textit{Parkinsonism and Related Disorders}. Oxford: Elsevier, 2020, roč.~81, December 2020, s.~190-193. ISSN~1353-8020. Dostupné z: https://dx.doi.org/10.1016/j.parkreldis.2020.10.048.
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