Galaxy InteractoMIX: An Integrated Computational Platform for
the Study of Protein–Protein Interaction Data

J 2021

Galaxy InteractoMIX: An Integrated Computational Platform for the Study of Protein–Protein Interaction Data

MIRELA-BOTA, Patricia; Joaquim AGUIRRE-PLANS; Alberto MESEGUER; Cristiano GALLETTI; Joan SEGURA et al.

Základní údaje

Originální název

Galaxy InteractoMIX: An Integrated Computational Platform for the Study of Protein–Protein Interaction Data

Autoři

MIRELA-BOTA, Patricia; Joaquim AGUIRRE-PLANS; Alberto MESEGUER; Cristiano GALLETTI; Joan SEGURA; Joan PLANAS IGLESIAS; Javi GARCIA-GARCIA; Emre GUNEY; Baldo OLIVA a Narcis FERNANDEZ-FUENTES

Vydání

Journal of Molecular Biology, London, Elsevier Science Ltd, 2021, 0022-2836

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.151

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/21:00121019

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

interactomics; network analyses; integration; Galaxy platform; workflows

Štítky

14314010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 6. 2021 11:10, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Protein interactions play a crucial role among the different functions of a cell and are central to our understanding of cellular processes both in health and disease. Here we present Galaxy InteractoMIX (http://galaxy.interactomix.com), a platform composed of 13 different computational tools each addressing specific aspects of the study of protein–protein interactions, ranging from large-scale cross-species protein-wide interactomes to atomic resolution level of protein complexes. Galaxy InteractoMIX provides an intuitive interface where users can retrieve consolidated interactomics data distributed across several databases or uncover links between diseases and genes by analyzing the interactomes underlying these diseases. The platform makes possible large-scale prediction and curation protein interactions using the conservation of motifs, interology, or presence or absence of key sequence signatures. The range of structure-based tools includes modeling and analysis of protein complexes, delineation of interfaces and the modeling of peptides acting as inhibitors of protein–protein interactions. Galaxy InteractoMIX includes a range of ready-to-use workflows to run complex analyses requiring minimal intervention by users. The potential range of applications of the platform covers different aspects of life science, biomedicine, biotechnology and drug discovery where protein associations are studied.

Návaznosti

EF16_027/0008360, projekt VaV

Název: Postdoc@MUNI

Citovat

MIRELA-BOTA, Patricia; Joaquim AGUIRRE-PLANS; Alberto MESEGUER; Cristiano GALLETTI; Joan SEGURA; Joan PLANAS IGLESIAS; Javi GARCIA-GARCIA; Emre GUNEY; Baldo OLIVA a Narcis FERNANDEZ-FUENTES. Galaxy InteractoMIX: An Integrated Computational Platform for the Study of Protein–Protein Interaction Data. Journal of Molecular Biology. London: Elsevier Science Ltd, 2021, roč. 433, č. 11, s. 166656-166666. ISSN 0022-2836. Dostupné z: https://doi.org/10.1016/j.jmb.2020.09.015.

@article{1733620,
   author = {MirelaandBota, Patricia and AguirreandPlans, Joaquim and Meseguer, Alberto and Galletti, Cristiano and Segura, Joan and Planas Iglesias, Joan and GarciaandGarcia, Javi and Guney, Emre and Oliva, Baldo and FernandezandFuentes, Narcis},
   article_location = {London},
   article_number = {11},
   doi = {https://doi.org/10.1016/j.jmb.2020.09.015},
   keywords = {interactomics; network analyses; integration; Galaxy platform; workflows},
   language = {eng},
   issn = {0022-2836},
   journal = {Journal of Molecular Biology},
   title = {Galaxy InteractoMIX: An Integrated Computational Platform for the Study of Protein–Protein Interaction Data},
   url = {https://doi.org/10.1016/j.jmb.2020.09.015},
   volume = {433},
   year = {2021}
}

TY  - JOUR
ID  - 1733620
AU  - Mirela-Bota, Patricia - Aguirre-Plans, Joaquim - Meseguer, Alberto - Galletti, Cristiano - Segura, Joan - Planas Iglesias, Joan - Garcia-Garcia, Javi - Guney, Emre - Oliva, Baldo - Fernandez-Fuentes, Narcis
PY  - 2021
TI  - Galaxy InteractoMIX: An Integrated Computational Platform for the Study of Protein–Protein Interaction Data
JF  - Journal of Molecular Biology
VL  - 433
IS  - 11
SP  - 166656
EP  - 166656
PB  - Elsevier Science Ltd
SN  - 00222836
KW  - interactomics
KW  - network analyses
KW  - integration
KW  - Galaxy platform
KW  - workflows
UR  - https://doi.org/10.1016/j.jmb.2020.09.015
L2  - https://doi.org/10.1016/j.jmb.2020.09.015
N2  - Protein interactions play a crucial role among the different functions of a cell and are central to our understanding of cellular processes both in health and disease. Here we present Galaxy InteractoMIX (http://galaxy.interactomix.com), a platform composed of 13 different computational tools each addressing specific aspects of the study of protein–protein interactions, ranging from large-scale cross-species protein-wide interactomes to atomic resolution level of protein complexes. Galaxy InteractoMIX provides an intuitive interface where users can retrieve consolidated interactomics data distributed across several databases or uncover links between diseases and genes by analyzing the interactomes underlying these diseases. The platform makes possible large-scale prediction and curation protein interactions using the conservation of motifs, interology, or presence or absence of key sequence signatures. The range of structure-based tools includes modeling and analysis of protein complexes, delineation of interfaces and the modeling of peptides acting as inhibitors of protein–protein interactions. Galaxy InteractoMIX includes a range of ready-to-use workflows to run complex analyses requiring minimal intervention by users. The potential range of applications of the platform covers different aspects of life science, biomedicine, biotechnology and drug discovery where protein associations are studied.
ER  -

MIRELA-BOTA, Patricia; Joaquim AGUIRRE-PLANS; Alberto MESEGUER; Cristiano GALLETTI; Joan SEGURA; Joan PLANAS IGLESIAS; Javi GARCIA-GARCIA; Emre GUNEY; Baldo OLIVA a Narcis FERNANDEZ-FUENTES. Galaxy InteractoMIX: An Integrated Computational Platform for the Study of Protein–Protein Interaction Data. \textit{Journal of Molecular Biology}. London: Elsevier Science Ltd, 2021, roč.~433, č.~11, s.~166656-166666. ISSN~0022-2836. Dostupné z: https://doi.org/10.1016/j.jmb.2020.09.015.

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