| WEELDEN, Willem Janvan, Casper REIJNEN, Heidi V.N. KÜSTERS-VANDEVELDE, Johan BULTEN, Peter BULT, Samuel LEUNG, Nicole C.M. VISSER, Maria SANTACANA, Peter BRONSERT, Marc HIRSCHFELD, Eva COLAS, Antonio GIL-MORENO, Armando REQUES, Gemma MANCEBO, Jutta HUVILA, Martin KOSKAS, Vít WEINBERGER, Markéta BEDNAŘÍKOVÁ, Jitka HAUSNEROVÁ, Marc P.L.M. SNIJDERS, Xavier MATIAS-GUIU a Frédéric AMANT. The cutoff for estrogen and progesterone receptor expression in endometrial cancer revisited: a European Network for Individualized Treatment of Endometrial Cancer collaboration study. Human Pathology. Philadelphia: Elseveir, 2021, roč. 109, March 2021, s. 80-91. ISSN 0046-8177. Dostupné z: https://dx.doi.org/10.1016/j.humpath.2020.12.003. |
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@article{1735416,
author = {Weelden, Willem Janvan and Reijnen, Casper and KüstersandVandevelde, Heidi V.N. and Bulten, Johan and Bult, Peter and Leung, Samuel and Visser, Nicole C.M. and Santacana, Maria and Bronsert, Peter and Hirschfeld, Marc and Colas, Eva and GilandMoreno, Antonio and Reques, Armando and Mancebo, Gemma and Huvila, Jutta and Koskas, Martin and Weinberger, Vít and Bednaříková, Markéta and Hausnerová, Jitka and Snijders, Marc P.L.M. and MatiasandGuiu, Xavier and Amant, Frédéric},
article_location = {Philadelphia},
article_number = {March 2021},
doi = {http://dx.doi.org/10.1016/j.humpath.2020.12.003},
keywords = {Endometrial cancer; Estrogen receptor; Progesterone receptor; Cutoff; Prognostic biomarker},
language = {eng},
issn = {0046-8177},
journal = {Human Pathology},
title = {The cutoff for estrogen and progesterone receptor expression in endometrial cancer revisited: a European Network for Individualized Treatment of Endometrial Cancer collaboration study},
url = {https://www.sciencedirect.com/science/article/pii/S0046817720302550?via%3Dihub},
volume = {109},
year = {2021}
}
TY - JOUR
ID - 1735416
AU - Weelden, Willem Janvan - Reijnen, Casper - Küsters-Vandevelde, Heidi V.N. - Bulten, Johan - Bult, Peter - Leung, Samuel - Visser, Nicole C.M. - Santacana, Maria - Bronsert, Peter - Hirschfeld, Marc - Colas, Eva - Gil-Moreno, Antonio - Reques, Armando - Mancebo, Gemma - Huvila, Jutta - Koskas, Martin - Weinberger, Vít - Bednaříková, Markéta - Hausnerová, Jitka - Snijders, Marc P.L.M. - Matias-Guiu, Xavier - Amant, Frédéric
PY - 2021
TI - The cutoff for estrogen and progesterone receptor expression in endometrial cancer revisited: a European Network for Individualized Treatment of Endometrial Cancer collaboration study
JF - Human Pathology
VL - 109
IS - March 2021
SP - 80-91
EP - 80-91
PB - Elseveir
SN - 00468177
KW - Endometrial cancer
KW - Estrogen receptor
KW - Progesterone receptor
KW - Cutoff
KW - Prognostic biomarker
UR - https://www.sciencedirect.com/science/article/pii/S0046817720302550?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/pii/S0046817720302550?via%3Dihub
N2 - There is no consensus on the cutoff for positivity of estrogen receptor (ER) and progesterone receptor (PR) in endometrial cancer (EC). Therefore, we determined the cutoff value for ER and PR expression with the strongest prognostic impact on the outcome. Immunohistochemical expression of ER and PR was scored as a percentage of positive EC cell nuclei. Cutoff values were related to disease-specific survival (DSS) and disease-free survival (DFS) using sensitivity, specificity, and multivariable regression analysis. The results were validated in an independent cohort. The study cohort (n = 527) included 82% of grade 1–2 and 18% of grade 3 EC. Specificity for DSS and DFS was highest for the cutoff values of 1–30%. Sensitivity was highest for the cutoff values of 80–90%. ER and PR expression were independent markers for DSS at cutoff values of 10% and 80%. Consequently, three subgroups with distinct clinical outcomes were identified: 0–10% of ER/PR expression with, unfavorable outcome (5-year DSS = 75.9–83.3%); 20–80% of ER/PR expression with, intermediate outcome (5-year DSS = 93.0–93.9%); and 90–100% of ER/PR expression with, favorable outcome (5-year DSS = 97.8–100%). The association between ER/PR subgroups and outcomes was confirmed in the validation cohort (n = 265). We propose classification of ER and PR expression based on a high-risk (0–10%), intermediate-risk (20–80%), and low-risk (90–100%) group.
ER -
WEELDEN, Willem Janvan, Casper REIJNEN, Heidi V.N. KÜSTERS-VANDEVELDE, Johan BULTEN, Peter BULT, Samuel LEUNG, Nicole C.M. VISSER, Maria SANTACANA, Peter BRONSERT, Marc HIRSCHFELD, Eva COLAS, Antonio GIL-MORENO, Armando REQUES, Gemma MANCEBO, Jutta HUVILA, Martin KOSKAS, Vít WEINBERGER, Markéta BEDNAŘÍKOVÁ, Jitka HAUSNEROVÁ, Marc P.L.M. SNIJDERS, Xavier MATIAS-GUIU a Frédéric AMANT. The cutoff for estrogen and progesterone receptor expression in endometrial cancer revisited: a European Network for Individualized Treatment of Endometrial Cancer collaboration study. \textit{Human Pathology}. Philadelphia: Elseveir, 2021, roč.~109, March 2021, s.~80-91. ISSN~0046-8177. Dostupné z: https://dx.doi.org/10.1016/j.humpath.2020.12.003.
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