Endocrine Disruptors: Very Low Doses with Genuinely High
Impacts on Male Reproduction

C 2020

Endocrine Disruptors: Very Low Doses with Genuinely High Impacts on Male Reproduction

JEŠETA, Michal a Jan NEVORAL

Základní údaje

Originální název

Endocrine Disruptors: Very Low Doses with Genuinely High Impacts on Male Reproduction

Autoři

JEŠETA, Michal a Jan NEVORAL

Vydání

London, Male Reproductive Health, od s. 1-21, 21 s. 2020

Nakladatel

IntechOpen

Další údaje

Jazyk

angličtina

Typ výsledku

Kapitola resp. kapitoly v odborné knize

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

tištěná verze "print"

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/20:00118068

Organizační jednotka

Lékařská fakulta

ISBN

978-1-78985-648-4

DOI

https://doi.org/10.5772/intechopen.88142

Klíčová slova anglicky

Endocrine Disruptors; Male Reproduction

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 3. 2021 11:49, Mgr. Tereza Miškechová

Anotace

V originále

Endocrine disruptors (EDs) are chemical substances that affect physiological processes in the body via hormonal regulation. They are often detected in food, plastic water bottles, cosmetics, and many other daily need items. Thereafter, EDs are detected in many bodily fluids, pointing out the real exposure to even very low doses. Permanent and long-term utilization of EDs has harmful effects on male reproductive health mainly due to interference with sex hormone synthesis and mechanism of action. However, with decreasing dosage of EDs, the possibilities of unpredictable modes of action arise. In addition to various molecular actions of individual EDs, the interference of individual ones represents another dimension of the ED issue. This review provides an overview of the EDs and their possible impact on reproductive health in males, with focus on sperm quality with the mighty potential of epigenetic transmission to further generations. The “posttranslational” effect of EDs in really low doses in real exposure routes is stigmatized in this review, being strongly considered as creeping molecular action of individual EDs as well as amplifications of their copresence in the environment.

Citovat

JEŠETA, Michal a Jan NEVORAL. Endocrine Disruptors: Very Low Doses with Genuinely High Impacts on Male Reproduction. In Wei Wu. Male Reproductive Health. London: IntechOpen, 2020, s. 1-21. ISBN 978-1-78985-648-4. Dostupné z: https://doi.org/10.5772/intechopen.88142.

@inbook{1735598,
   author = {Ješeta, Michal and Nevoral, Jan},
   address = {London},
   booktitle = {Male Reproductive Health},
   doi = {https://doi.org/10.5772/intechopen.88142},
   editor = {Wei Wu},
   keywords = {Endocrine Disruptors; Male Reproduction},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {London},
   isbn = {978-1-78985-648-4},
   pages = {1-21},
   publisher = {IntechOpen},
   title = {Endocrine Disruptors: Very Low Doses with Genuinely High Impacts on Male Reproduction},
   url = {https://www.intechopen.com/books/male-reproductive-health/endocrine-disruptors-very-low-doses-with-genuinely-high-impacts-on-male-reproduction},
   year = {2020}
}

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ID  - 1735598
AU  - Ješeta, Michal - Nevoral, Jan
PY  - 2020
TI  - Endocrine Disruptors: Very Low Doses with Genuinely High Impacts on Male Reproduction
VL  - Neuveden
PB  - IntechOpen
CY  - London
SN  - 9781789856484
KW  - Endocrine Disruptors
KW  - Male Reproduction
UR  - https://www.intechopen.com/books/male-reproductive-health/endocrine-disruptors-very-low-doses-with-genuinely-high-impacts-on-male-reproduction
L2  - https://www.intechopen.com/books/male-reproductive-health/endocrine-disruptors-very-low-doses-with-genuinely-high-impacts-on-male-reproduction
N2  - Endocrine disruptors (EDs) are chemical substances that affect physiological processes in the body via hormonal regulation. They are often detected in food, plastic water bottles, cosmetics, and many other daily need items. Thereafter, EDs are detected in many bodily fluids, pointing out the real exposure to even very low doses. Permanent and long-term utilization of EDs has harmful effects on male reproductive health mainly due to interference with sex hormone synthesis and mechanism of action. However, with decreasing dosage of EDs, the possibilities of unpredictable modes of action arise. In addition to various molecular actions of individual EDs, the interference of individual ones represents another dimension of the ED issue. This review provides an overview of the EDs and their possible impact on reproductive health in males, with focus on sperm quality with the mighty potential of epigenetic transmission to further generations. The “posttranslational” effect of EDs in really low doses in real exposure routes is stigmatized in this review, being strongly considered as creeping molecular action of individual EDs as well as amplifications of their copresence in the environment.
ER  -

JEŠETA, Michal a Jan NEVORAL. Endocrine Disruptors: Very Low Doses with Genuinely High Impacts on Male Reproduction. In Wei Wu. \textit{Male Reproductive Health}. London: IntechOpen, 2020, s.~1-21. ISBN~978-1-78985-648-4. Dostupné z: https://doi.org/10.5772/intechopen.88142.

Přehled o publikaci