Quantitative assessment of left ventricular longitudinal
function and myocardial deformation in Duchenne muscular
dystrophy patients

J 2021

Quantitative assessment of left ventricular longitudinal function and myocardial deformation in Duchenne muscular dystrophy patients

PANOVSKÝ, Roman, Martin PEŠL, Jan MÁCHAL, Tomáš HOLEČEK, Věra FEITOVÁ et. al.

Základní údaje

Originální název

Quantitative assessment of left ventricular longitudinal function and myocardial deformation in Duchenne muscular dystrophy patients

Autoři

PANOVSKÝ, Roman (203 Česká republika, garant, domácí), Martin PEŠL (203 Česká republika, domácí), Jan MÁCHAL (203 Česká republika, domácí), Tomáš HOLEČEK (203 Česká republika), Věra FEITOVÁ (203 Česká republika), Lenka JUŘÍKOVÁ (203 Česká republika), Lucia MASÁROVÁ (703 Slovensko, domácí), Eva PEŠLOVÁ (203 Česká republika, domácí), Lukáš OPATŘIL (203 Česká republika, domácí), Mary Luz MOJICA-PISCIOTTI a Vladimír KINCL (203 Česká republika, domácí)

Vydání

Orphanet Journal of Rare Diseases, London, BMC, 2021, 1750-1172

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30101 Human genetics

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.303

Kód RIV

RIV/00216224:14110/21:00121084

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1186/s13023-021-01704-9

UT WoS

000616474600005

Klíčová slova anglicky

Cardiac magnetic resonance; Duchenne muscular dystrophy; Feature tracking; Strain analysis

Štítky

14110115, 14110127, 14110513, 14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 4. 2021 14:06, Mgr. Tereza Miškechová

Anotace

V originále

BackgroundDuchenne muscular dystrophy (DMD) manifests in males mainly by skeletal muscle impairment, but also by cardiac dysfunction. The assessment of the early phases of cardiac involvement using echocardiography is often very difficult to perform in these patients. The aim of the study was to use cardiac magnetic resonance (CMR) strain analysis and mitral annular plane systolic excursion (MAPSE) in the detection of early left ventricular (LV) dysfunction in DMD patients. Methods and resultsIn total, 51 male DMD patients and 18 matched controls were examined by CMR. MAPSE measurement and functional analysis using feature tracking (FT) were performed. Three groups of patients were evaluated: A/ patients with LGE and LV EF<50% (n=8), B/ patients with LGE and LVEF50% (n=13), and C/ patients without LGE and LVEF >= 50% (n=30). MAPSE and global LV strains of the 3 DMD groups were compared to controls (n=18). Groups A and B had significantly reduced values of MAPSE, global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) in comparison to controls (p<0.05). The values of MAPSE (11.61.9 v 13.72.7 mm) and GCS (- 26.2 +/- 4.2 v - 30.0 +/- 5.1%) were significantly reduced in group C compared to the controls (p<0.05).Conclusion DMD patients had decreased LV systolic function measured by MAPSE and global LV strain even in the case of normal LV EF and the absence of LGE. FT and MAPSE measurement provide sensitive assessment of early cardiac involvement in DMD patients.

Citovat

PANOVSKÝ, Roman, Martin PEŠL, Jan MÁCHAL, Tomáš HOLEČEK, Věra FEITOVÁ, Lenka JUŘÍKOVÁ, Lucia MASÁROVÁ, Eva PEŠLOVÁ, Lukáš OPATŘIL, Mary Luz MOJICA-PISCIOTTI a Vladimír KINCL. Quantitative assessment of left ventricular longitudinal function and myocardial deformation in Duchenne muscular dystrophy patients. Orphanet Journal of Rare Diseases. London: BMC, 2021, roč. 16, č. 1, s. 1-9. ISSN 1750-1172. Dostupné z: https://dx.doi.org/10.1186/s13023-021-01704-9.

@article{1737157,
   author = {Panovský, Roman and Pešl, Martin and Máchal, Jan and Holeček, Tomáš and Feitová, Věra and Juříková, Lenka and Masárová, Lucia and Pešlová, Eva and Opatřil, Lukáš and MojicaandPisciotti, Mary Luz and Kincl, Vladimír},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/s13023-021-01704-9},
   keywords = {Cardiac magnetic resonance; Duchenne muscular dystrophy; Feature tracking; Strain analysis},
   language = {eng},
   issn = {1750-1172},
   journal = {Orphanet Journal of Rare Diseases},
   title = {Quantitative assessment of left ventricular longitudinal function and myocardial deformation in Duchenne muscular dystrophy patients},
   url = {https://ojrd.biomedcentral.com/articles/10.1186/s13023-021-01704-9},
   volume = {16},
   year = {2021}
}

TY  - JOUR
ID  - 1737157
AU  - Panovský, Roman - Pešl, Martin - Máchal, Jan - Holeček, Tomáš - Feitová, Věra - Juříková, Lenka - Masárová, Lucia - Pešlová, Eva - Opatřil, Lukáš - Mojica-Pisciotti, Mary Luz - Kincl, Vladimír
PY  - 2021
TI  - Quantitative assessment of left ventricular longitudinal function and myocardial deformation in Duchenne muscular dystrophy patients
JF  - Orphanet Journal of Rare Diseases
VL  - 16
IS  - 1
SP  - 1-9
EP  - 1-9
PB  - BMC
SN  - 17501172
KW  - Cardiac magnetic resonance
KW  - Duchenne muscular dystrophy
KW  - Feature tracking
KW  - Strain analysis
UR  - https://ojrd.biomedcentral.com/articles/10.1186/s13023-021-01704-9
L2  - https://ojrd.biomedcentral.com/articles/10.1186/s13023-021-01704-9
N2  - BackgroundDuchenne muscular dystrophy (DMD) manifests in males mainly by skeletal muscle impairment, but also by cardiac dysfunction. The assessment of the early phases of cardiac involvement using echocardiography is often very difficult to perform in these patients. The aim of the study was to use cardiac magnetic resonance (CMR) strain analysis and mitral annular plane systolic excursion (MAPSE) in the detection of early left ventricular (LV) dysfunction in DMD patients. Methods and resultsIn total, 51 male DMD patients and 18 matched controls were examined by CMR. MAPSE measurement and functional analysis using feature tracking (FT) were performed. Three groups of patients were evaluated: A/ patients with LGE and LV EF<50% (n=8), B/ patients with LGE and LVEF50% (n=13), and C/ patients without LGE and LVEF >= 50% (n=30). MAPSE and global LV strains of the 3 DMD groups were compared to controls (n=18). Groups A and B had significantly reduced values of MAPSE, global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) in comparison to controls (p<0.05). The values of MAPSE (11.61.9 v 13.72.7 mm) and GCS (- 26.2 +/- 4.2 v - 30.0 +/- 5.1%) were significantly reduced in group C compared to the controls (p<0.05).Conclusion DMD patients had decreased LV systolic function measured by MAPSE and global LV strain even in the case of normal LV EF and the absence of LGE. FT and MAPSE measurement provide sensitive assessment of early cardiac involvement in DMD patients.
ER  -

PANOVSKÝ, Roman, Martin PEŠL, Jan MÁCHAL, Tomáš HOLEČEK, Věra FEITOVÁ, Lenka JUŘÍKOVÁ, Lucia MASÁROVÁ, Eva PEŠLOVÁ, Lukáš OPATŘIL, Mary Luz MOJICA-PISCIOTTI a Vladimír KINCL. Quantitative assessment of left ventricular longitudinal function and myocardial deformation in Duchenne muscular dystrophy patients. \textit{Orphanet Journal of Rare Diseases}. London: BMC, 2021, roč.~16, č.~1, s.~1-9. ISSN~1750-1172. Dostupné z: https://dx.doi.org/10.1186/s13023-021-01704-9.

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