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@article{1739876,
author = {Soukup, Jiri and Hornychova, Helena and Manethova, Monika and Michalova, Kvetoslava and Michnova, Ludmila and Popovska, Lenka and Skarkova, Veronika and Cesak, Tomas and Netuka, David and Ryska, Ales and Cap, Jan and Hana, Vaclav and Hana, Vaclav, Jr. and Krsek, Michal and Dvorakova, Eva and Krcma, Michal and Lazurova, Ivica and Olšovská, Věra and Starý, Karel and Vanuga, Peter and Gabalec, Filip},
article_location = {HOBOKEN},
article_number = {5},
doi = {http://dx.doi.org/10.1111/jcmm.16173},
keywords = {acromegaly; PITNET; pituitary neoplasm; somatostatin receptor},
language = {eng},
issn = {1582-1838},
journal = {Journal of Cellular and Molecular Medicine},
title = {Predictive and prognostic significance of tumour subtype, SSTR1-5 and e-cadherin expression in a well-defined cohort of patients with acromegaly},
url = {https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcmm.16173},
volume = {25},
year = {2021}
}
TY - JOUR
ID - 1739876
AU - Soukup, Jiri - Hornychova, Helena - Manethova, Monika - Michalova, Kvetoslava - Michnova, Ludmila - Popovska, Lenka - Skarkova, Veronika - Cesak, Tomas - Netuka, David - Ryska, Ales - Cap, Jan - Hana, Vaclav - Hana, Vaclav, Jr. - Krsek, Michal - Dvorakova, Eva - Krcma, Michal - Lazurova, Ivica - Olšovská, Věra - Starý, Karel - Vanuga, Peter - Gabalec, Filip
PY - 2021
TI - Predictive and prognostic significance of tumour subtype, SSTR1-5 and e-cadherin expression in a well-defined cohort of patients with acromegaly
JF - Journal of Cellular and Molecular Medicine
VL - 25
IS - 5
SP - 2484-2492
EP - 2484-2492
PB - Wiley Blackwell
SN - 15821838
KW - acromegaly
KW - PITNET
KW - pituitary neoplasm
KW - somatostatin receptor
UR - https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcmm.16173
L2 - https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcmm.16173
N2 - In somatotroph pituitary tumours, somatostatin analogue (SSA) therapy outcomes vary throughout the studies. We performed an analysis of cohort of patients with acromegaly from the Czech registry to identify new prognostic and predictive factors. Clinical data of patients were collected, and complex immunohistochemical assessment of tumour samples was performed (SSTR1-5, dopamine D2 receptor, E-cadherin, AIP). The study included 110 patients. In 31, SSA treatment outcome was evaluated. Sparsely granulated tumours (SGST) differed from the other subtypes in expression of SSTR2A, SSTR3, SSTR5 and E-cadherin and occurred more often in young. No other clinical differences were observed. Trouillas grading system showed association with age, tumour size and SSTR2A expression. Factors significantly associated with SSA treatment outcome included age, IGF1 levels, tumour size and expression of E-cadherin and SSTR2A. In the group of SGST, poor SSA response was observed in younger patients with larger tumours, lower levels of SSTR2A and higher Ki67. We observed no relationship with expression of other proteins including AIP. No predictive value of E-cadherin was observed when tumour subtype was considered. Multiple additional factors apart from SSTR2A expression can predict treatment outcome in patients with acromegaly.
ER -
SOUKUP, Jiri, Helena HORNYCHOVA, Monika MANETHOVA, Kvetoslava MICHALOVA, Ludmila MICHNOVA, Lenka POPOVSKA, Veronika SKARKOVA, Tomas CESAK, David NETUKA, Ales RYSKA, Jan CAP, Vaclav HANA, Vaclav, Jr. HANA, Michal KRSEK, Eva DVORAKOVA, Michal KRCMA, Ivica LAZUROVA, Věra OLŠOVSKÁ, Karel STARÝ, Peter VANUGA and Filip GABALEC. Predictive and prognostic significance of tumour subtype, SSTR1-5 and e-cadherin expression in a well-defined cohort of patients with acromegaly. \textit{Journal of Cellular and Molecular Medicine}. HOBOKEN: Wiley Blackwell, 2021, vol.~25, No~5, p.~2484-2492. ISSN~1582-1838. Available from: https://dx.doi.org/10.1111/jcmm.16173.
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