Další formáty:
BibTeX
LaTeX
RIS
@article{1742578,
author = {Chalupová, Marta and Suchý, Pavel and Pražanová, Gabriela and Bartošová, Ladislava and Sopuch, T and Havelka, P},
article_location = {HOBOKEN},
article_number = {6},
doi = {http://dx.doi.org/10.1002/jbm.a.34098},
keywords = {kidney; rats; Wistar; nephrectomy; hemostasis; cellulose},
language = {eng},
issn = {1549-3296},
journal = {Journal of Biomedical Materials Research Part A},
title = {Local tissue reaction after the application of topical hemostatic agents in a rat partial nephrectomy model},
volume = {100A},
year = {2012}
}
TY - JOUR
ID - 1742578
AU - Chalupová, Marta - Suchý, Pavel - Pražanová, Gabriela - Bartošová, Ladislava - Sopuch, T - Havelka, P
PY - 2012
TI - Local tissue reaction after the application of topical hemostatic agents in a rat partial nephrectomy model
JF - Journal of Biomedical Materials Research Part A
VL - 100A
IS - 6
SP - 1582-1590
EP - 1582-1590
PB - WILEY
SN - 15493296
KW - kidney
KW - rats
KW - Wistar
KW - nephrectomy
KW - hemostasis
KW - cellulose
N2 - Various hemostatics are used for renal surgical procedures. We investigated the hemostatic efficacy of cellulose derivatives on the model of partial nephrectomy in rats focusing on the local reaction of renal parenchyma. A total of 50 Wistar rats were divided into five groups of 10 animals each. Partial nephrectomy of the caudal pole without hilar vascular control was performed. Oxidized cellulose (OC), sodium salt of oxycellulose (OCN), carboxymethyl cellulose (CMC), dialdehyde cellulose (DAC), and gelatin-based hemostatic (C) were applied to the bleeding wounds. The time to hemostasis was monitored. Half of the animals were euthanized after 3 days, the second half 30 days from the experiment start date. The left kidney was excised and subjected to histopathological examination. The biochemical data was subjected to statistical analysis. The time to hemostasis in all groups was significantly less than in the C group (in OC p = 0.0057, OCN p = 0.0039, CMC and DAC p = 0.0001). In the C group, massive hemorrhages and necrosis did occur. In the OC and OCN groups, there were regenerative changes, a receding inflammatory reaction and hemorrhage. DAC caused an immune reaction and massive interstitial hemorrhages with biochemical signs of liver damage. Parenchyma in CMC revealed a reduction of necrosis and interstitial hemorrhages with regenerative processes. The most effective hemostatics were CMC and OC, achieving the best results both in the time to hemostasis, and for histopathological evaluation. (C) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 2012.
ER -
CHALUPOVÁ, Marta, Pavel SUCHÝ, Gabriela PRAŽANOVÁ, Ladislava BARTOŠOVÁ, T SOPUCH a P HAVELKA. Local tissue reaction after the application of topical hemostatic agents in a rat partial nephrectomy model. \textit{Journal of Biomedical Materials Research Part A}. HOBOKEN: WILEY, 2012, roč.~100A, č.~6, s.~1582-1590. ISSN~1549-3296. Dostupné z: https://dx.doi.org/10.1002/jbm.a.34098.
|
