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@article{1742761, author = {Nováková Tkadlečková, Veronika and Pitronova, V. and Kubová, Kateřina and Pavloková, Sylvie and Elbl, Jan and Novotny, R. and Vetchý, David and Vysloužil, Jakub}, article_location = {NEW YORK}, article_number = {6}, doi = {http://dx.doi.org/10.1208/s12249-020-01770-5}, keywords = {silicone elastomer; vaginal ring; dimension parameters; DOE; design of experiment; drug release}, language = {eng}, issn = {1530-9932}, journal = {AAPS PHARMSCITECH}, title = {Matrix Vaginal Rings for Female Dogs-Effect of Altering Dimensions on Mechanical Properties and Dissolution Characteristics, and In vivo Safety Study}, url = {https://link.springer.com/article/10.1208/s12249-020-01770-5}, volume = {21}, year = {2020} }
TY - JOUR ID - 1742761 AU - Nováková Tkadlečková, Veronika - Pitronova, V. - Kubová, Kateřina - Pavloková, Sylvie - Elbl, Jan - Novotny, R. - Vetchý, David - Vysloužil, Jakub PY - 2020 TI - Matrix Vaginal Rings for Female Dogs-Effect of Altering Dimensions on Mechanical Properties and Dissolution Characteristics, and In vivo Safety Study JF - AAPS PHARMSCITECH VL - 21 IS - 6 SP - 1-12 EP - 1-12 PB - SPRINGER SN - 15309932 KW - silicone elastomer KW - vaginal ring KW - dimension parameters KW - DOE KW - design of experiment KW - drug release UR - https://link.springer.com/article/10.1208/s12249-020-01770-5 L2 - https://link.springer.com/article/10.1208/s12249-020-01770-5 N2 - The vaginal rings research is almost exclusively focused on rings for human medicine, although the dosage form offers improvement of therapeutic effect in other mammals as well. This contribution studied an effect of varying dimension parameters (diameter 20, 30 or 40 mm; height 3, 4 or 5 mm; width of annulus 5, 7.5 or 10 mm) on mechanical properties and dissolution behaviour of silicone vaginal rings with constant drug amount, intended for use in dogs. Results showed that altering dimensions influenced mechanical properties (compressive force, tensile strength and resistance of removal thread),in vitrodrug release and water uptake. The removal thread resistance was increasing with increasing height and width. Compression force was higher for the rings with smaller diameter. The total drug release was increasing with decreasing height and rising diameter, surface area and water uptake during dissolution test. The initial dissolution rate was slower for the rings with higher width. As the best candidate for use in model dog subjects, the ring with 30 mm diameter, 3 mm height and 7.5 mm width was found. These drug-free vaginal rings were further tested inin vivosafety study. The results did not show any major deviation from the physiological conditions. ER -
NOVÁKOVÁ TKADLEČKOVÁ, Veronika, V. PITRONOVA, Kateřina KUBOVÁ, Sylvie PAVLOKOVÁ, Jan ELBL, R. NOVOTNY, David VETCHÝ a Jakub VYSLOUŽIL. Matrix Vaginal Rings for Female Dogs-Effect of Altering Dimensions on Mechanical Properties and Dissolution Characteristics, and In vivo Safety Study. \textit{AAPS PHARMSCITECH}. NEW YORK: SPRINGER, 2020, roč.~21, č.~6, s.~1-12. ISSN~1530-9932. Dostupné z: https://dx.doi.org/10.1208/s12249-020-01770-5.
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