| BOČKOVÁ, Martina, Martin LAMOŠ, Petr KLIMES, Pavel JURAK, Josef HALAMEK, Sabina GOLDEMUNDOVÁ, Marek BALÁŽ a Ivan REKTOR. Suboptimal response to STN-DBS in Parkinson's disease can be identified via reaction times in a motor cognitive paradigm. Online. Journal of Neural Transmission. WIEN: SPRINGER WIEN, 2020, roč. 127, č. 12, s. 1579-1588. ISSN 0300-9564. Dostupné z: https://dx.doi.org/10.1007/s00702-020-02254-3. [citováno 2024-04-23] |
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@article{1744840,
author = {Bočková, Martina and Lamoš, Martin and Klimes, Petr and Jurak, Pavel and Halamek, Josef and Goldemundová, Sabina and Baláž, Marek and Rektor, Ivan},
article_location = {WIEN},
article_number = {12},
doi = {http://dx.doi.org/10.1007/s00702-020-02254-3},
keywords = {HD-EEG; Deep brain stimulation; Reaction time; Time frequency analysis; Biomarkers},
language = {eng},
issn = {0300-9564},
journal = {Journal of Neural Transmission},
title = {Suboptimal response to STN-DBS in Parkinson's disease can be identified via reaction times in a motor cognitive paradigm},
url = {https://link.springer.com/article/10.1007%2Fs00702-020-02254-3},
volume = {127},
year = {2020}
}
TY - JOUR
ID - 1744840
AU - Bočková, Martina - Lamoš, Martin - Klimes, Petr - Jurak, Pavel - Halamek, Josef - Goldemundová, Sabina - Baláž, Marek - Rektor, Ivan
PY - 2020
TI - Suboptimal response to STN-DBS in Parkinson's disease can be identified via reaction times in a motor cognitive paradigm
JF - Journal of Neural Transmission
VL - 127
IS - 12
SP - 1579-1588
EP - 1579-1588
PB - SPRINGER WIEN
SN - 03009564
KW - HD-EEG
KW - Deep brain stimulation
KW - Reaction time
KW - Time frequency analysis
KW - Biomarkers
UR - https://link.springer.com/article/10.1007%2Fs00702-020-02254-3
N2 - Although deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson's disease (PD) is generally a successful therapy, adverse events and insufficient clinical effect can complicate the treatment in some patients. We studied clinical parameters and cortical oscillations related to STN-DBS to identify patients with suboptimal responses. High-density EEG was recorded during a visual oddball three-stimuli paradigm in DBS "off" and "on" conditions in 32 PD patients with STN-DBS. Pre-processed data were reconstructed into the source space and the time-frequency analysis was evaluated. We identified a subgroup of six patients with longer reaction times (RT) during the DBS "on" state than in the DBS "off" state after target stimuli. These subjects had lower motor responsiveness to DBS and decreased memory test results compared to the other subjects. Moreover, the alpha and beta power decrease (event-related desynchronizations, ERD), known as an activation correlate linked to motor and cognitive processing, was also reduced in the DBS "on" condition in these patients. A subgroup of PD patients with a suboptimal response to STN-DBS was identified. Evaluation of RT could potentially serve as a biomarker for responsiveness to STN-DBS.
ER -
BOČKOVÁ, Martina, Martin LAMOŠ, Petr KLIMES, Pavel JURAK, Josef HALAMEK, Sabina GOLDEMUNDOVÁ, Marek BALÁŽ a Ivan REKTOR. Suboptimal response to STN-DBS in Parkinson's disease can be identified via reaction times in a motor cognitive paradigm. Online. \textit{Journal of Neural Transmission}. WIEN: SPRINGER WIEN, 2020, roč.~127, č.~12, s.~1579-1588. ISSN~0300-9564. Dostupné z: https://dx.doi.org/10.1007/s00702-020-02254-3. [citováno 2024-04-23]
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