Composites of yeast glucan particles and curcumin lead to
improvement of dextran sulfate sodium-induced acute bowel
inflammation in rats

J 2021

Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats

ROTREKL, Dominik, P. SALAMUNOVA, Lenka PARÁKOVÁ, Ondrej BAĎO, I. SALON et. al.

Základní údaje

Originální název

Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats

Autoři

ROTREKL, Dominik (203 Česká republika, garant, domácí), P. SALAMUNOVA, Lenka PARÁKOVÁ (203 Česká republika, domácí), Ondrej BAĎO (703 Slovensko, domácí), I. SALON, F. STEPANEK, J. HANUS a J. HOSEK

Vydání

Carbohydrate Polymers, Oxford, ELSEVIER SCI LTD, 2021, 0144-8617

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 10.723

Kód RIV

RIV/00216224:14160/21:00121162

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.1016/j.carbpol.2020.117142

UT WoS

000596264200008

Klíčová slova anglicky

Colitis targeting; Curcumin; beta-Glucan; Yeast glucan particles; Inflammation

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 22. 2. 2021 13:01, PharmDr. Jitka Michlíčková

Anotace

V originále

The goal of this work was to assess the usability of yeast glucan particles (GPs) as carriers for curcumin and determine the beneficial effect of a pharmacological composite of curcumin in GPs on dextran sulfate sodium induced colitis in rats. The assessment of the anti-inflammatory effect of particular substances was evaluated on the basis of the calculated disease activity index and by assessment of cytokines and enzymes from the gut tissue - tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta 1, interleukin (IL)-1 beta, IL-6, IL-10, IL-17, catalase, superoxide dismutase 2, myeloperoxidase (MPO), and matrix metalloproteinase 9. Composites of GPs with incorporated curcumin showed promising results with the capability to lower symptoms of colitis and significantly decrease the production of pro-inflammatory cytokines TNF-alpha, IL-1 beta, IL-6, and the activity of MPO, as well. The anti-inflammatory effect of the composites was greater than those of pure GPs or curcumin.

Citovat

ROTREKL, Dominik, P. SALAMUNOVA, Lenka PARÁKOVÁ, Ondrej BAĎO, I. SALON, F. STEPANEK, J. HANUS a J. HOSEK. Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats. Carbohydrate Polymers. Oxford: ELSEVIER SCI LTD, 2021, roč. 252, č. 117142, s. 1-9. ISSN 0144-8617. Dostupné z: https://dx.doi.org/10.1016/j.carbpol.2020.117142.

@article{1744937,
   author = {Rotrekl, Dominik and Salamunova, P. and Paráková, Lenka and Baďo, Ondrej and Salon, I. and Stepanek, F. and Hanus, J. and Hosek, J.},
   article_location = {Oxford},
   article_number = {117142},
   doi = {http://dx.doi.org/10.1016/j.carbpol.2020.117142},
   keywords = {Colitis targeting; Curcumin; beta-Glucan; Yeast glucan particles; Inflammation},
   language = {eng},
   issn = {0144-8617},
   journal = {Carbohydrate Polymers},
   title = {Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats},
   url = {https://www.sciencedirect.com/science/article/pii/S0144861720313151?via%3Dihub},
   volume = {252},
   year = {2021}
}

TY  - JOUR
ID  - 1744937
AU  - Rotrekl, Dominik - Salamunova, P. - Paráková, Lenka - Baďo, Ondrej - Salon, I. - Stepanek, F. - Hanus, J. - Hosek, J.
PY  - 2021
TI  - Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats
JF  - Carbohydrate Polymers
VL  - 252
IS  - 117142
SP  - 1-9
EP  - 1-9
PB  - ELSEVIER SCI LTD
SN  - 01448617
KW  - Colitis targeting
KW  - Curcumin
KW  - beta-Glucan
KW  - Yeast glucan particles
KW  - Inflammation
UR  - https://www.sciencedirect.com/science/article/pii/S0144861720313151?via%3Dihub
N2  - The goal of this work was to assess the usability of yeast glucan particles (GPs) as carriers for curcumin and determine the beneficial effect of a pharmacological composite of curcumin in GPs on dextran sulfate sodium induced colitis in rats. The assessment of the anti-inflammatory effect of particular substances was evaluated on the basis of the calculated disease activity index and by assessment of cytokines and enzymes from the gut tissue - tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta 1, interleukin (IL)-1 beta, IL-6, IL-10, IL-17, catalase, superoxide dismutase 2, myeloperoxidase (MPO), and matrix metalloproteinase 9. Composites of GPs with incorporated curcumin showed promising results with the capability to lower symptoms of colitis and significantly decrease the production of pro-inflammatory cytokines TNF-alpha, IL-1 beta, IL-6, and the activity of MPO, as well. The anti-inflammatory effect of the composites was greater than those of pure GPs or curcumin.
ER  -

ROTREKL, Dominik, P. SALAMUNOVA, Lenka PARÁKOVÁ, Ondrej BAĎO, I. SALON, F. STEPANEK, J. HANUS a J. HOSEK. Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats. \textit{Carbohydrate Polymers}. Oxford: ELSEVIER SCI LTD, 2021, roč.~252, č.~117142, s.~1-9. ISSN~0144-8617. Dostupné z: https://dx.doi.org/10.1016/j.carbpol.2020.117142.

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