TREML, Jakub, Markéta GAZDOVÁ, Karel ŠMEJKAL, M. SUDOMOVA, P. KUBATKA a S. T. S. HASSAN. Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development. Viruses-Basel. Basel, Switzerland: MDPI AG, 2020, roč. 12, č. 2, s. 1-42. ISSN 1999-4915. doi:10.3390/v12020154.
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Základní údaje
Originální název Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development
Autoři TREML, Jakub (203 Česká republika, domácí), Markéta GAZDOVÁ (203 Česká republika, domácí), Karel ŠMEJKAL (203 Česká republika, domácí), M. SUDOMOVA, P. KUBATKA a S. T. S. HASSAN (garant).
Vydání Viruses-Basel, Basel, Switzerland, MDPI AG, 2020, 1999-4915.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30104 Pharmacology and pharmacy
Stát vydavatele Švýcarsko
Utajení není předmětem státního či obchodního tajemství
WWW URL
Impakt faktor Impact factor: 3.811 v roce 2018
Kód RIV RIV/00216224:14160/20:00118247
Organizační jednotka Farmaceutická fakulta
Doi http://dx.doi.org/10.3390/v12020154
UT WoS 000521256600005
Klíčová slova anglicky herpes simplex virus infection; bioactive natural products; drug resistance; drug development; antiherpetic drugs; preclinical and clinical studies; mechanisms of action
Štítky rivok, ÚMF, ÚPL
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Mgr. Hana Hurtová, učo 244985. Změněno: 24. 2. 2021 10:56.
Anotace
Recently, the problem of viral infection, particularly the infection with herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), has dramatically increased and caused a significant challenge to public health due to the rising problem of drug resistance. The antiherpetic drug resistance crisis has been attributed to the overuse of these medications, as well as the lack of new drug development by the pharmaceutical industry due to reduced economic inducements and challenging regulatory requirements. Therefore, the development of novel antiviral drugs against HSV infections would be a step forward in improving global combat against these infections. The incorporation of biologically active natural products into anti-HSV drug development at the clinical level has gained limited attention to date. Thus, the search for new drugs from natural products that could enter clinical practice with lessened resistance, less undesirable effects, and various mechanisms of action is greatly needed to break the barriers to novel antiherpetic drug development, which, in turn, will pave the road towards the efficient and safe treatment of HSV infections. In this review, we aim to provide an up-to-date overview of the recent advances in natural antiherpetic agents. Additionally, this paper covers a large scale of phenolic compounds, alkaloids, terpenoids, polysaccharides, peptides, and other miscellaneous compounds derived from various sources of natural origin (plants, marine organisms, microbial sources, lichen species, insects, and mushrooms) with promising activities against HSV infections; these are in vitro and in vivo studies. This work also highlights bioactive natural products that could be used as templates for the further development of anti-HSV drugs at both animal and clinical levels, along with the potential mechanisms by which these compounds induce anti-HSV properties. Future insights into the development of these molecules as safe and effective natural anti-HSV drugs are also debated.
VytisknoutZobrazeno: 18. 5. 2021 02:53