SYCHROVÁ, Alice, Ivana KOLÁRIKOVÁ, Milan ŽEMLIČKA a Karel ŠMEJKAL. Natural compounds with dual antimicrobial and anti-inflammatory effects. Phytochemistry reviews. Dordrecht: Springer, roč. 19, č. 6, s. 1471-1502. ISSN 1568-7767. doi:10.1007/s11101-020-09694-5. 2020.
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Základní údaje
Originální název Natural compounds with dual antimicrobial and anti-inflammatory effects
Autoři SYCHROVÁ, Alice (203 Česká republika, domácí), Ivana KOLÁRIKOVÁ, Milan ŽEMLIČKA (203 Česká republika, domácí) a Karel ŠMEJKAL (203 Česká republika, garant, domácí).
Vydání Phytochemistry reviews, Dordrecht, Springer, 2020, 1568-7767.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30104 Pharmacology and pharmacy
Stát vydavatele Nizozemské království
Utajení není předmětem státního či obchodního tajemství
WWW URL
Impakt faktor Impact factor: 5.374
Kód RIV RIV/00216224:14160/20:00118254
Organizační jednotka Farmaceutická fakulta
Doi http://dx.doi.org/10.1007/s11101-020-09694-5
UT WoS 000543051200001
Klíčová slova anglicky Alkaloids; Antibacterial; Anti-inflammatory; Chalcones; Coumarins; Dual inhibitors; Flavanones; Flavones; Flavonols; Isoflavonoids; Lignans; Other substances; Prenylated flavones; Synergy; Terpenoids
Štítky rivok, ÚPL
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Mgr. Hana Hurtová, učo 244985. Změněno: 6. 4. 2021 13:34.
Anotace
Increasing antimicrobial resistance, together with the occurrence of side effects of NSAIDs or glucocorticoids represents certain motivation to search for new natural dual antimicrobial and anti-inflammatory drugs. We here present selected natural compounds, possessing both antimicrobial and anti-inflammatory activity. The review contains also the information about structure-activity relationships with respect to natural or semisynthetic origin of compounds and synergy effects between natural dual inhibitors and commercially available antibiotics. Data published from 2000 to 2018 were obtained using databases Google Scholar, Science Direct and Web of Science, and searching keywords such asalkaloids,anti-inflammatory activity, antimicrobial activity, chalcones, coumarins, flavonoids, IC50, lignans, MIC, natural compounds,synergistic effectandterpenoids, alone or in a combination. The primary criteria for the selection of appropriate compounds were the MICs and IC(50)s used for a quantification of effects. The natural compounds with activity close to the reference substances or showing MIC up to 32 mu g ml(-1), and IC(50)of anti-inflammatory effect up to 15 mu M were considered as promising. When available, information about in vivo testing was included. Reviewed dual inhibitors can represent modern therapeutic approach, especially when the process of inflammation is followed by a secondary bacterial infection. Benefits of dual inhibitors are based on better compliance of patients, decreased number of side effects and extended spectrum of action. [GRAPHICS] .
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