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@article{1745916,
author = {Sychrová, Alice and Koláriková, Ivana and Žemlička, Milan and Šmejkal, Karel},
article_location = {Dordrecht},
article_number = {6},
doi = {http://dx.doi.org/10.1007/s11101-020-09694-5},
keywords = {Alkaloids; Antibacterial; Anti-inflammatory; Chalcones; Coumarins; Dual inhibitors; Flavanones; Flavones; Flavonols; Isoflavonoids; Lignans; Other substances; Prenylated flavones; Synergy; Terpenoids},
language = {eng},
issn = {1568-7767},
journal = {Phytochemistry reviews},
title = {Natural compounds with dual antimicrobial and anti-inflammatory effects},
url = {https://link.springer.com/article/10.1007/s11101-020-09694-5},
volume = {19},
year = {2020}
}
TY - JOUR
ID - 1745916
AU - Sychrová, Alice - Koláriková, Ivana - Žemlička, Milan - Šmejkal, Karel
PY - 2020
TI - Natural compounds with dual antimicrobial and anti-inflammatory effects
JF - Phytochemistry reviews
VL - 19
IS - 6
SP - 1471-1502
EP - 1471-1502
PB - Springer
SN - 15687767
KW - Alkaloids
KW - Antibacterial
KW - Anti-inflammatory
KW - Chalcones
KW - Coumarins
KW - Dual inhibitors
KW - Flavanones
KW - Flavones
KW - Flavonols
KW - Isoflavonoids
KW - Lignans
KW - Other substances
KW - Prenylated flavones
KW - Synergy
KW - Terpenoids
UR - https://link.springer.com/article/10.1007/s11101-020-09694-5
N2 - Increasing antimicrobial resistance, together with the occurrence of side effects of NSAIDs or glucocorticoids represents certain motivation to search for new natural dual antimicrobial and anti-inflammatory drugs. We here present selected natural compounds, possessing both antimicrobial and anti-inflammatory activity. The review contains also the information about structure-activity relationships with respect to natural or semisynthetic origin of compounds and synergy effects between natural dual inhibitors and commercially available antibiotics. Data published from 2000 to 2018 were obtained using databases Google Scholar, Science Direct and Web of Science, and searching keywords such asalkaloids,anti-inflammatory activity, antimicrobial activity, chalcones, coumarins, flavonoids, IC50, lignans, MIC, natural compounds,synergistic effectandterpenoids, alone or in a combination. The primary criteria for the selection of appropriate compounds were the MICs and IC(50)s used for a quantification of effects. The natural compounds with activity close to the reference substances or showing MIC up to 32 mu g ml(-1), and IC(50)of anti-inflammatory effect up to 15 mu M were considered as promising. When available, information about in vivo testing was included. Reviewed dual inhibitors can represent modern therapeutic approach, especially when the process of inflammation is followed by a secondary bacterial infection. Benefits of dual inhibitors are based on better compliance of patients, decreased number of side effects and extended spectrum of action. [GRAPHICS] .
ER -
SYCHROVÁ, Alice, Ivana KOLÁRIKOVÁ, Milan ŽEMLIČKA and Karel ŠMEJKAL. Natural compounds with dual antimicrobial and anti-inflammatory effects. \textit{Phytochemistry reviews}. Dordrecht: Springer, 2020, vol.~19, No~6, p.~1471-1502. ISSN~1568-7767. Available from: https://dx.doi.org/10.1007/s11101-020-09694-5.
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